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LncRNA GLCC1 promotes colorectal carcinogenesis and glucose metabolism by stabilizing c-Myc

Long non-coding RNAs (lncRNAs) contribute to colorectal cancer (CRC). However, the role of lncRNAs in CRC metabolism, especially glucose metabolism remains largely unknown. In this study, we identify a lncRNA, GLCC1, which is significantly upregulated under glucose starvation in CRC cells, supportin...

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Detalles Bibliográficos
Autores principales: Tang, Jiayin, Yan, Tingting, Bao, Yujie, Shen, Chaoqin, Yu, Chenyang, Zhu, Xiaoqiang, Tian, Xianglong, Guo, Fangfang, Liang, Qian, Liu, Qiang, Zhong, Ming, Chen, Jinxian, Ge, Zhizheng, Li, Xiaobo, Chen, Xiaoyu, Cui, Yun, Chen, Yingxuan, Zou, Weiping, Chen, Haoyan, Hong, Jie, Fang, Jing-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677832/
https://www.ncbi.nlm.nih.gov/pubmed/31375671
http://dx.doi.org/10.1038/s41467-019-11447-8
Descripción
Sumario:Long non-coding RNAs (lncRNAs) contribute to colorectal cancer (CRC). However, the role of lncRNAs in CRC metabolism, especially glucose metabolism remains largely unknown. In this study, we identify a lncRNA, GLCC1, which is significantly upregulated under glucose starvation in CRC cells, supporting cell survival and proliferation by enhancing glycolysis. Mechanistically, GLCC1 stabilizes c-Myc transcriptional factor from ubiquitination by direct interaction with HSP90 chaperon and further specifies the transcriptional modification pattern on c-Myc target genes, such as LDHA, consequently reprogram glycolytic metabolism for CRC proliferation. Clinically, GLCC1 is associated with tumorigenesis, tumor size and predicts poor prognosis. Thus, GLCC1 is mechanistically, functionally, and clinically oncogenic in colorectal cancer. Targeting GLCC1 and its pathway may be meaningful for treating patients with colorectal cancer.