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LncRNA GLCC1 promotes colorectal carcinogenesis and glucose metabolism by stabilizing c-Myc
Long non-coding RNAs (lncRNAs) contribute to colorectal cancer (CRC). However, the role of lncRNAs in CRC metabolism, especially glucose metabolism remains largely unknown. In this study, we identify a lncRNA, GLCC1, which is significantly upregulated under glucose starvation in CRC cells, supportin...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677832/ https://www.ncbi.nlm.nih.gov/pubmed/31375671 http://dx.doi.org/10.1038/s41467-019-11447-8 |
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author | Tang, Jiayin Yan, Tingting Bao, Yujie Shen, Chaoqin Yu, Chenyang Zhu, Xiaoqiang Tian, Xianglong Guo, Fangfang Liang, Qian Liu, Qiang Zhong, Ming Chen, Jinxian Ge, Zhizheng Li, Xiaobo Chen, Xiaoyu Cui, Yun Chen, Yingxuan Zou, Weiping Chen, Haoyan Hong, Jie Fang, Jing-Yuan |
author_facet | Tang, Jiayin Yan, Tingting Bao, Yujie Shen, Chaoqin Yu, Chenyang Zhu, Xiaoqiang Tian, Xianglong Guo, Fangfang Liang, Qian Liu, Qiang Zhong, Ming Chen, Jinxian Ge, Zhizheng Li, Xiaobo Chen, Xiaoyu Cui, Yun Chen, Yingxuan Zou, Weiping Chen, Haoyan Hong, Jie Fang, Jing-Yuan |
author_sort | Tang, Jiayin |
collection | PubMed |
description | Long non-coding RNAs (lncRNAs) contribute to colorectal cancer (CRC). However, the role of lncRNAs in CRC metabolism, especially glucose metabolism remains largely unknown. In this study, we identify a lncRNA, GLCC1, which is significantly upregulated under glucose starvation in CRC cells, supporting cell survival and proliferation by enhancing glycolysis. Mechanistically, GLCC1 stabilizes c-Myc transcriptional factor from ubiquitination by direct interaction with HSP90 chaperon and further specifies the transcriptional modification pattern on c-Myc target genes, such as LDHA, consequently reprogram glycolytic metabolism for CRC proliferation. Clinically, GLCC1 is associated with tumorigenesis, tumor size and predicts poor prognosis. Thus, GLCC1 is mechanistically, functionally, and clinically oncogenic in colorectal cancer. Targeting GLCC1 and its pathway may be meaningful for treating patients with colorectal cancer. |
format | Online Article Text |
id | pubmed-6677832 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-66778322019-08-05 LncRNA GLCC1 promotes colorectal carcinogenesis and glucose metabolism by stabilizing c-Myc Tang, Jiayin Yan, Tingting Bao, Yujie Shen, Chaoqin Yu, Chenyang Zhu, Xiaoqiang Tian, Xianglong Guo, Fangfang Liang, Qian Liu, Qiang Zhong, Ming Chen, Jinxian Ge, Zhizheng Li, Xiaobo Chen, Xiaoyu Cui, Yun Chen, Yingxuan Zou, Weiping Chen, Haoyan Hong, Jie Fang, Jing-Yuan Nat Commun Article Long non-coding RNAs (lncRNAs) contribute to colorectal cancer (CRC). However, the role of lncRNAs in CRC metabolism, especially glucose metabolism remains largely unknown. In this study, we identify a lncRNA, GLCC1, which is significantly upregulated under glucose starvation in CRC cells, supporting cell survival and proliferation by enhancing glycolysis. Mechanistically, GLCC1 stabilizes c-Myc transcriptional factor from ubiquitination by direct interaction with HSP90 chaperon and further specifies the transcriptional modification pattern on c-Myc target genes, such as LDHA, consequently reprogram glycolytic metabolism for CRC proliferation. Clinically, GLCC1 is associated with tumorigenesis, tumor size and predicts poor prognosis. Thus, GLCC1 is mechanistically, functionally, and clinically oncogenic in colorectal cancer. Targeting GLCC1 and its pathway may be meaningful for treating patients with colorectal cancer. Nature Publishing Group UK 2019-08-02 /pmc/articles/PMC6677832/ /pubmed/31375671 http://dx.doi.org/10.1038/s41467-019-11447-8 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Tang, Jiayin Yan, Tingting Bao, Yujie Shen, Chaoqin Yu, Chenyang Zhu, Xiaoqiang Tian, Xianglong Guo, Fangfang Liang, Qian Liu, Qiang Zhong, Ming Chen, Jinxian Ge, Zhizheng Li, Xiaobo Chen, Xiaoyu Cui, Yun Chen, Yingxuan Zou, Weiping Chen, Haoyan Hong, Jie Fang, Jing-Yuan LncRNA GLCC1 promotes colorectal carcinogenesis and glucose metabolism by stabilizing c-Myc |
title | LncRNA GLCC1 promotes colorectal carcinogenesis and glucose metabolism by stabilizing c-Myc |
title_full | LncRNA GLCC1 promotes colorectal carcinogenesis and glucose metabolism by stabilizing c-Myc |
title_fullStr | LncRNA GLCC1 promotes colorectal carcinogenesis and glucose metabolism by stabilizing c-Myc |
title_full_unstemmed | LncRNA GLCC1 promotes colorectal carcinogenesis and glucose metabolism by stabilizing c-Myc |
title_short | LncRNA GLCC1 promotes colorectal carcinogenesis and glucose metabolism by stabilizing c-Myc |
title_sort | lncrna glcc1 promotes colorectal carcinogenesis and glucose metabolism by stabilizing c-myc |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677832/ https://www.ncbi.nlm.nih.gov/pubmed/31375671 http://dx.doi.org/10.1038/s41467-019-11447-8 |
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