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Examining the identification of age-related atrophy between T1 and T1 + T2-FLAIR cortical thickness measurements
Cortical thickness is traditionally derived from T1-weighted MRI images. Recent studies have shown an improvement in segmentation with the combination of T1 + T2-FLAIR images. MRI data from 54 adults (mean: 71 years, 65–81 years, 48% females) that are part of an ongoing cohort study were analyzed to...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677836/ https://www.ncbi.nlm.nih.gov/pubmed/31375692 http://dx.doi.org/10.1038/s41598-019-47294-2 |
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author | Lindroth, Heidi Nair, Veena A. Stanfield, Casandra Casey, Cameron Mohanty, Rosaleena Wayer, Daniel Rowley, Paul Brown, Roger Prabhakaran, Vivek Sanders, Robert D. |
author_facet | Lindroth, Heidi Nair, Veena A. Stanfield, Casandra Casey, Cameron Mohanty, Rosaleena Wayer, Daniel Rowley, Paul Brown, Roger Prabhakaran, Vivek Sanders, Robert D. |
author_sort | Lindroth, Heidi |
collection | PubMed |
description | Cortical thickness is traditionally derived from T1-weighted MRI images. Recent studies have shown an improvement in segmentation with the combination of T1 + T2-FLAIR images. MRI data from 54 adults (mean: 71 years, 65–81 years, 48% females) that are part of an ongoing cohort study were analyzed to investigate whether T1 + T2-FLAIR cortical thickness measurements were superior to those derived from T1-weighted images in identifying age-related atrophy. T1-weighted and T2-FLAIR MRI images were processed through FreeSurfer v6.0. Data was extracted using the Desikan-Killiany (DKT) atlas. FreeSurfer’s GUI QDEC examined age-related atrophy. Nonparametric tests, effect sizes, and Pearson correlations examined differences between T1-only and T1 + T2-FLAIR cortical thickness data. These analyses demonstrated that T1 + T2-FLAIR processed images significantly improved the segmentation of gray matter (chi-square x(2), p < 0.05) and demonstrated significantly thicker cortical thickness means (p < 0.05) with medium to large effect sizes. Significant regions of age-related cortical atrophy were identified within the T1 + T2-FLAIR data (FDR corrected, p < 0.05). This is in contrast to the T1-only data where no regions survived FDR correction. In summary, T1 + T2-FLAIR data were associated with significant improvement in cortical segmentation and the identification of age-related cortical atrophy. Future studies should consider employing this imaging strategy to obtain cortical thickness measurements sensitive to age-related changes. |
format | Online Article Text |
id | pubmed-6677836 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-66778362019-08-08 Examining the identification of age-related atrophy between T1 and T1 + T2-FLAIR cortical thickness measurements Lindroth, Heidi Nair, Veena A. Stanfield, Casandra Casey, Cameron Mohanty, Rosaleena Wayer, Daniel Rowley, Paul Brown, Roger Prabhakaran, Vivek Sanders, Robert D. Sci Rep Article Cortical thickness is traditionally derived from T1-weighted MRI images. Recent studies have shown an improvement in segmentation with the combination of T1 + T2-FLAIR images. MRI data from 54 adults (mean: 71 years, 65–81 years, 48% females) that are part of an ongoing cohort study were analyzed to investigate whether T1 + T2-FLAIR cortical thickness measurements were superior to those derived from T1-weighted images in identifying age-related atrophy. T1-weighted and T2-FLAIR MRI images were processed through FreeSurfer v6.0. Data was extracted using the Desikan-Killiany (DKT) atlas. FreeSurfer’s GUI QDEC examined age-related atrophy. Nonparametric tests, effect sizes, and Pearson correlations examined differences between T1-only and T1 + T2-FLAIR cortical thickness data. These analyses demonstrated that T1 + T2-FLAIR processed images significantly improved the segmentation of gray matter (chi-square x(2), p < 0.05) and demonstrated significantly thicker cortical thickness means (p < 0.05) with medium to large effect sizes. Significant regions of age-related cortical atrophy were identified within the T1 + T2-FLAIR data (FDR corrected, p < 0.05). This is in contrast to the T1-only data where no regions survived FDR correction. In summary, T1 + T2-FLAIR data were associated with significant improvement in cortical segmentation and the identification of age-related cortical atrophy. Future studies should consider employing this imaging strategy to obtain cortical thickness measurements sensitive to age-related changes. Nature Publishing Group UK 2019-08-02 /pmc/articles/PMC6677836/ /pubmed/31375692 http://dx.doi.org/10.1038/s41598-019-47294-2 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Lindroth, Heidi Nair, Veena A. Stanfield, Casandra Casey, Cameron Mohanty, Rosaleena Wayer, Daniel Rowley, Paul Brown, Roger Prabhakaran, Vivek Sanders, Robert D. Examining the identification of age-related atrophy between T1 and T1 + T2-FLAIR cortical thickness measurements |
title | Examining the identification of age-related atrophy between T1 and T1 + T2-FLAIR cortical thickness measurements |
title_full | Examining the identification of age-related atrophy between T1 and T1 + T2-FLAIR cortical thickness measurements |
title_fullStr | Examining the identification of age-related atrophy between T1 and T1 + T2-FLAIR cortical thickness measurements |
title_full_unstemmed | Examining the identification of age-related atrophy between T1 and T1 + T2-FLAIR cortical thickness measurements |
title_short | Examining the identification of age-related atrophy between T1 and T1 + T2-FLAIR cortical thickness measurements |
title_sort | examining the identification of age-related atrophy between t1 and t1 + t2-flair cortical thickness measurements |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677836/ https://www.ncbi.nlm.nih.gov/pubmed/31375692 http://dx.doi.org/10.1038/s41598-019-47294-2 |
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