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Effects of metformin on tumor hypoxia and radiotherapy efficacy: a [(18)F]HX4 PET imaging study in colorectal cancer xenografts

BACKGROUND: In a colorectal cancer xenograft model, we investigated the therapeutic effect of metformin on tumor hypoxia with [(18)F]flortanidazole ([(18)F]HX4) small-animal positron emission tomography (μPET). We also assessed the additive effect of metformin on long-term radiotherapy outcome and w...

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Detalles Bibliográficos
Autores principales:	De Bruycker, Sven, Vangestel, Christel, Staelens, Steven, wyffels, Leonie, Detrez, Jan, Verschuuren, Marlies, De Vos, Winnok H., Pauwels, Patrick, Van den Wyngaert, Tim, Stroobants, Sigrid
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677842/ https://www.ncbi.nlm.nih.gov/pubmed/31375940 http://dx.doi.org/10.1186/s13550-019-0543-4

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