Cargando…

Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington’s disease

Huntington’s disease (HD) is a neurodegenerative disorder that manifests with movement dysfunction. The expression of mutant Huntingtin (mHTT) disrupts the functions of brain cells. Galectin-3 (Gal3) is a lectin that has not been extensively explored in brain diseases. Herein, we showed that the pla...

Descripción completa

Detalles Bibliográficos
Autores principales:	Siew, Jian Jing, Chen, Hui-Mei, Chen, Huan-Yuan, Chen, Hung-Lin, Chen, Chiung-Mei, Soong, Bing-Wen, Wu, Yih-Ru, Chang, Ching-Pang, Chan, Yi-Chen, Lin, Chun-Hung, Liu, Fu-Tong, Chern, Yijuang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677843/ https://www.ncbi.nlm.nih.gov/pubmed/31375685 http://dx.doi.org/10.1038/s41467-019-11441-0

Ejemplares similares

High Protein Diet and Huntington's Disease
por: Chen, Chiung-Mei, et al.
Publicado: (2015)

Besides Huntington's disease, does brain-type creatine kinase play a role in other forms of hearing impairment resulting from a common pathological cause?
por: Lin, Yow-Sien, et al.
Publicado: (2011)

Down-regulation of miR-9* in the peripheral leukocytes of Huntington’s disease patients
por: Chang, Kuo-Hsuan, et al.
Publicado: (2017)

Nuclear translocation of AMPK-α1 potentiates striatal neurodegeneration in Huntington’s disease
por: Ju, Tz-Chuen, et al.
Publicado: (2011)

Altered Aconitase 2 Activity in Huntington’s Disease Peripheral Blood Cells and Mouse Model Striatum
por: Chen, Chiung-Mei, et al.
Publicado: (2017)

Targeting the equilibrative nucleoside transporter ENT1 in Huntington disease
por: Guitart, Xavier, et al.
Publicado: (2017)

Alternations of Lipoprotein Profiles in the Plasma as Biomarkers of Huntington’s Disease
por: Chang, Kuo-Hsuan, et al.
Publicado: (2023)

Downregulation of Genes Involved in Metabolism and Oxidative Stress in the Peripheral Leukocytes of Huntington's Disease Patients
por: Chang, Kuo-Hsuan, et al.
Publicado: (2012)

Insights into GABA(A)ergic system alteration in Huntington's disease
por: Hsu, Yi-Ting, et al.
Publicado: (2018)

Human Mesenchymal Stem Cells Prolong Survival and Ameliorate Motor Deficit through Trophic Support in Huntington's Disease Mouse Models
por: Lin, Yuan-Ta, et al.
Publicado: (2011)

Emerging roles of dysregulated adenosine homeostasis in brain disorders with a specific focus on neurodegenerative diseases
por: Chang, Ching-Pang, et al.
Publicado: (2021)

Increased Prothrombin, Apolipoprotein A-IV, and Haptoglobin in the Cerebrospinal Fluid of Patients with Huntington's Disease
por: Huang, Yen-Chu, et al.
Publicado: (2011)

A New Drug Design Targeting the Adenosinergic System for Huntington's Disease
por: Huang, Nai-Kuei, et al.
Publicado: (2011)

Fixel-Based Analysis Effectively Identifies White Matter Tract Degeneration in Huntington’s Disease
por: Oh, Sher Li, et al.
Publicado: (2021)

Microglial Lectins in Health and Neurological Diseases
por: Siew, Jian Jing, et al.
Publicado: (2018)

The D2 Dopamine Receptor Interferes With the Protective Effect of the A(2A) Adenosine Receptor on TDP-43 Mislocalization in Experimental Models of Motor Neuron Degeneration
por: Lai, Chia-You, et al.
Publicado: (2018)

Genetic targeting or pharmacological inhibition of galectin-3 dampens microglia reactivity and delays retinal degeneration
por: Tabel, Mona, et al.
Publicado: (2022)

Galectin-3 and Its Genetic Variation rs4644 Modulate Enterovirus 71 Infection
por: Huang, Wen-Chan, et al.
Publicado: (2016)

Alterations of Plasma Galectin-3 and C3 Levels in Patients with Parkinson’s Disease
por: Wu, Hsiu-Chuan, et al.
Publicado: (2021)

Galectin-7 regulates keratinocyte proliferation and differentiation through JNK-miR-203-p63 signaling
por: Chen, Hung-Lin, et al.
Publicado: (2016)

The Role of Microglia and Astrocytes in Huntington’s Disease
por: Palpagama, Thulani H., et al.
Publicado: (2019)

Fibroblast Growth Factor 20 Gene Polymorphism in Parkinson’s Disease in Asian Population: A Meta-Analysis
por: Chiang, Han-Lin, et al.
Publicado: (2021)

Associations of Matrix Metalloproteinase-9 and Tissue Inhibitory Factor-1 Polymorphisms With Parkinson Disease in Taiwan
por: Chen, Yi-Chun, et al.
Publicado: (2016)

Galectin-3 in Microglia-Mediated Neuroinflammation: Implications for Central Nervous System Diseases
por: Ge, Meng-Meng, et al.
Publicado: (2022)

Type VI adenylyl cyclase negatively regulates GluN2B-mediated LTD and spatial reversal learning
por: Chang, Ching-Pang, et al.
Publicado: (2016)

Dissecting the Structure–Activity Relationship of Galectin–Ligand Interactions
por: Chan, Yi-Chen, et al.
Publicado: (2018)

Galectin-3: a key player in microglia-mediated neuroinflammation and Alzheimer's disease
por: Tan, Yinyin, et al.
Publicado: (2021)

Sialylation and Galectin-3 in Microglia-Mediated Neuroinflammation and Neurodegeneration
por: Puigdellívol, Mar, et al.
Publicado: (2020)

Calreticulin and Galectin-3 Opsonise Bacteria for Phagocytosis by Microglia
por: Cockram, Tom O. J., et al.
Publicado: (2019)

Neurovascular abnormalities in brain disorders: highlights with angiogenesis and magnetic resonance imaging studies
por: Chen, Chiao-Chi V, et al.
Publicado: (2013)

Coumarin-chalcone hybrid LM-021 and indole derivative NC009-1 targeting inflammation and oxidative stress to protect BE(2)-M17 cells against α-synuclein toxicity
por: Yang, Pei-Ning, et al.
Publicado: (2023)

Genetic Analysis of EGLN1 C127S Variant in Taiwanese Parkinson's Disease
por: Chiang, Han-Lin, et al.
Publicado: (2020)

Shaoyao Gancao Tang (SG-Tang), a formulated Chinese medicine, reduces aggregation and exerts neuroprotection in spinocerebellar ataxia type 17 (SCA17) cell and mouse models
por: Chen, Chiung-Mei, et al.
Publicado: (2019)

Role of galectins in lung cancer
por: Chang, Wei-An, et al.
Publicado: (2017)

Spinocerebellar ataxia type 8 larger triplet expansion alters histone modification and induces RNA foci
por: Chen, I-Cheng, et al.
Publicado: (2009)

The Role of Galectin-3 in the Kidneys
por: Chen, Szu-Chia, et al.
Publicado: (2016)

Aldosterone Induced Galectin-3 Secretion In Vitro and In Vivo: From Cells to Humans
por: Lin, Yen-Hung, et al.
Publicado: (2014)

Microglia at Sites of Atrophy Restrict the Progression of Retinal Degeneration via Galectin-3 and Trem2 Interactions
por: Yu, Chen, et al.
Publicado: (2023)

Contribution of Energy Dysfunction to Impaired Protein Translation in Neurodegenerative Diseases
por: Liu, Yu-Ju, et al.
Publicado: (2021)

Rare VPS35 A320V Variant in Taiwanese Parkinson’s Disease Indicates Disrupted CI-MPR Sorting and Impaired Mitochondrial Morphology
por: Wu, Yih-Ru, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_52k4bjf6jhh2vpf88ikgpoumj5