The role of the light chain in the structure and binding activity of two cattle antibodies that neutralize bovine respiratory syncytial virus

Cattle antibodies have unusually long CDR3 loops in their heavy chains (HCs), and limited light chain (LC) diversity, raising the question of whether these mask the effect of LC variation on antigen recognition. We have investigated the role of the LC in the structure and activity of two neutralizin...

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Detalles Bibliográficos
Autores principales: Ren, Jingshan, Nettleship, Joanne E., Harris, Gemma, Mwangi, William, Rhaman, Nahid, Grant, Clare, Kotecha, Abhay, Fry, Elizabeth, Charleston, Bryan, Stuart, David I., Hammond, John, Owens, Raymond J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pergamon Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677920/
https://www.ncbi.nlm.nih.gov/pubmed/31100550
http://dx.doi.org/10.1016/j.molimm.2019.04.026

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