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Miniaturized phased-array ultrasound and photoacoustic endoscopic imaging system

Visualization and detection of early-stage gynecological malignancies represents a challenge for imaging due to limiting factors including tissue accessibility, device ease of use, and accuracy of imaging modalities. In this work, we introduce a miniaturized phased-array ultrasound and photoacoustic...

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Autores principales: Basij, Maryam, Yan, Yan, Alshahrani, Suhail S., Helmi, Hamid, Burton, Timothy K., Burmeister, Jay W., Dominello, Michael M., Winer, Ira S., Mehrmohammadi, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677929/
https://www.ncbi.nlm.nih.gov/pubmed/31388487
http://dx.doi.org/10.1016/j.pacs.2019.100139
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author Basij, Maryam
Yan, Yan
Alshahrani, Suhail S.
Helmi, Hamid
Burton, Timothy K.
Burmeister, Jay W.
Dominello, Michael M.
Winer, Ira S.
Mehrmohammadi, Mohammad
author_facet Basij, Maryam
Yan, Yan
Alshahrani, Suhail S.
Helmi, Hamid
Burton, Timothy K.
Burmeister, Jay W.
Dominello, Michael M.
Winer, Ira S.
Mehrmohammadi, Mohammad
author_sort Basij, Maryam
collection PubMed
description Visualization and detection of early-stage gynecological malignancies represents a challenge for imaging due to limiting factors including tissue accessibility, device ease of use, and accuracy of imaging modalities. In this work, we introduce a miniaturized phased-array ultrasound and photoacoustic endoscopic probe which is capable of providing structural, functional, and molecular data for the characterization of gynecologic disease. The proposed probe consists of a 64-element ultrasound phased-array transducer coupled to a fiber-optic light delivery system for co-registered ultrasound and photoacoustic imaging. The fabricated US and PA imaging endoscope’s diameter is 7.5 mm, allowing for potential passage through the cervical canal and thus an intimate contact with gynecological tissues such as the cervical canal and uterus. The developed endoscopic probe was tested and characterized in a set of tissue-mimicking phantoms. US and PA resolutions were measured experimentally using 200 μm diameter wires, resulting in apparent axial and lateral diameters of 289 μm and 299 μm for US, and 308 μm and 378 μm for PA, respectively. The probe’s abilities to operate in both discrete and integrated illumination/acquisition were tested in gelatin phantoms with embedded optical absorbers with the results demonstrating the ability to acquire volumetric dual-modal US and PA images.
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spelling pubmed-66779292019-08-06 Miniaturized phased-array ultrasound and photoacoustic endoscopic imaging system Basij, Maryam Yan, Yan Alshahrani, Suhail S. Helmi, Hamid Burton, Timothy K. Burmeister, Jay W. Dominello, Michael M. Winer, Ira S. Mehrmohammadi, Mohammad Photoacoustics Research Article Visualization and detection of early-stage gynecological malignancies represents a challenge for imaging due to limiting factors including tissue accessibility, device ease of use, and accuracy of imaging modalities. In this work, we introduce a miniaturized phased-array ultrasound and photoacoustic endoscopic probe which is capable of providing structural, functional, and molecular data for the characterization of gynecologic disease. The proposed probe consists of a 64-element ultrasound phased-array transducer coupled to a fiber-optic light delivery system for co-registered ultrasound and photoacoustic imaging. The fabricated US and PA imaging endoscope’s diameter is 7.5 mm, allowing for potential passage through the cervical canal and thus an intimate contact with gynecological tissues such as the cervical canal and uterus. The developed endoscopic probe was tested and characterized in a set of tissue-mimicking phantoms. US and PA resolutions were measured experimentally using 200 μm diameter wires, resulting in apparent axial and lateral diameters of 289 μm and 299 μm for US, and 308 μm and 378 μm for PA, respectively. The probe’s abilities to operate in both discrete and integrated illumination/acquisition were tested in gelatin phantoms with embedded optical absorbers with the results demonstrating the ability to acquire volumetric dual-modal US and PA images. Elsevier 2019-07-25 /pmc/articles/PMC6677929/ /pubmed/31388487 http://dx.doi.org/10.1016/j.pacs.2019.100139 Text en © 2019 Published by Elsevier GmbH. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Basij, Maryam
Yan, Yan
Alshahrani, Suhail S.
Helmi, Hamid
Burton, Timothy K.
Burmeister, Jay W.
Dominello, Michael M.
Winer, Ira S.
Mehrmohammadi, Mohammad
Miniaturized phased-array ultrasound and photoacoustic endoscopic imaging system
title Miniaturized phased-array ultrasound and photoacoustic endoscopic imaging system
title_full Miniaturized phased-array ultrasound and photoacoustic endoscopic imaging system
title_fullStr Miniaturized phased-array ultrasound and photoacoustic endoscopic imaging system
title_full_unstemmed Miniaturized phased-array ultrasound and photoacoustic endoscopic imaging system
title_short Miniaturized phased-array ultrasound and photoacoustic endoscopic imaging system
title_sort miniaturized phased-array ultrasound and photoacoustic endoscopic imaging system
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677929/
https://www.ncbi.nlm.nih.gov/pubmed/31388487
http://dx.doi.org/10.1016/j.pacs.2019.100139
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