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LOXL3 Function Beyond Amino Oxidase and Role in Pathologies, Including Cancer
Lysyl oxidase like 3 (LOXL3) is a copper-dependent amine oxidase responsible for the crosslinking of collagen and elastin in the extracellular matrix. LOXL3 belongs to a family including other members: LOX, LOXL1, LOXL2, and LOXL4. Autosomal recessive mutations are rare and described in patients wit...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678131/ https://www.ncbi.nlm.nih.gov/pubmed/31340433 http://dx.doi.org/10.3390/ijms20143587 |
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author | Laurentino, Talita de S. Soares, Roseli da S. Marie, Suely K. N. Oba-Shinjo, Sueli M. |
author_facet | Laurentino, Talita de S. Soares, Roseli da S. Marie, Suely K. N. Oba-Shinjo, Sueli M. |
author_sort | Laurentino, Talita de S. |
collection | PubMed |
description | Lysyl oxidase like 3 (LOXL3) is a copper-dependent amine oxidase responsible for the crosslinking of collagen and elastin in the extracellular matrix. LOXL3 belongs to a family including other members: LOX, LOXL1, LOXL2, and LOXL4. Autosomal recessive mutations are rare and described in patients with Stickler syndrome, early-onset myopia and non-syndromic cleft palate. Along with an essential function in embryonic development, multiple biological functions have been attributed to LOXL3 in various pathologies related to amino oxidase activity. Additionally, various novel roles have been described for LOXL3, such as the oxidation of fibronectin in myotendinous junction formation, and of deacetylation and deacetylimination activities of STAT3 to control of inflammatory response. In tumors, three distinct roles were described: (1) LOXL3 interacts with SNAIL and contributes to proliferation and metastasis by inducing epithelial-mesenchymal transition in pancreatic ductal adenocarcinoma cells; (2) LOXL3 is localized predominantly in the nucleus associated with invasion and poor gastric cancer prognosis; (3) LOXL3 interacts with proteins involved in DNA stability and mitosis completion, contributing to melanoma progression and sustained proliferation. Here we review the structure, function and activity of LOXL3 in normal and pathological conditions and discuss the potential of LOXL3 as a therapeutic target in various diseases. |
format | Online Article Text |
id | pubmed-6678131 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-66781312019-08-19 LOXL3 Function Beyond Amino Oxidase and Role in Pathologies, Including Cancer Laurentino, Talita de S. Soares, Roseli da S. Marie, Suely K. N. Oba-Shinjo, Sueli M. Int J Mol Sci Review Lysyl oxidase like 3 (LOXL3) is a copper-dependent amine oxidase responsible for the crosslinking of collagen and elastin in the extracellular matrix. LOXL3 belongs to a family including other members: LOX, LOXL1, LOXL2, and LOXL4. Autosomal recessive mutations are rare and described in patients with Stickler syndrome, early-onset myopia and non-syndromic cleft palate. Along with an essential function in embryonic development, multiple biological functions have been attributed to LOXL3 in various pathologies related to amino oxidase activity. Additionally, various novel roles have been described for LOXL3, such as the oxidation of fibronectin in myotendinous junction formation, and of deacetylation and deacetylimination activities of STAT3 to control of inflammatory response. In tumors, three distinct roles were described: (1) LOXL3 interacts with SNAIL and contributes to proliferation and metastasis by inducing epithelial-mesenchymal transition in pancreatic ductal adenocarcinoma cells; (2) LOXL3 is localized predominantly in the nucleus associated with invasion and poor gastric cancer prognosis; (3) LOXL3 interacts with proteins involved in DNA stability and mitosis completion, contributing to melanoma progression and sustained proliferation. Here we review the structure, function and activity of LOXL3 in normal and pathological conditions and discuss the potential of LOXL3 as a therapeutic target in various diseases. MDPI 2019-07-23 /pmc/articles/PMC6678131/ /pubmed/31340433 http://dx.doi.org/10.3390/ijms20143587 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Laurentino, Talita de S. Soares, Roseli da S. Marie, Suely K. N. Oba-Shinjo, Sueli M. LOXL3 Function Beyond Amino Oxidase and Role in Pathologies, Including Cancer |
title | LOXL3 Function Beyond Amino Oxidase and Role in Pathologies, Including Cancer |
title_full | LOXL3 Function Beyond Amino Oxidase and Role in Pathologies, Including Cancer |
title_fullStr | LOXL3 Function Beyond Amino Oxidase and Role in Pathologies, Including Cancer |
title_full_unstemmed | LOXL3 Function Beyond Amino Oxidase and Role in Pathologies, Including Cancer |
title_short | LOXL3 Function Beyond Amino Oxidase and Role in Pathologies, Including Cancer |
title_sort | loxl3 function beyond amino oxidase and role in pathologies, including cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678131/ https://www.ncbi.nlm.nih.gov/pubmed/31340433 http://dx.doi.org/10.3390/ijms20143587 |
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