Cargando…
Time on Therapy for at Least Three Months Correlates with Overall Survival in Metastatic Renal Cell Carcinoma
With 15 drugs currently approved for the treatment of metastatic renal cell carcinoma (mRCC) and even more combination regimens with immunotherapy on the horizon, there remains a distinct lack of molecular biomarkers for therapeutic efficacy. Our study reports on real-world clinical outcomes of mRCC...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678132/ https://www.ncbi.nlm.nih.gov/pubmed/31319594 http://dx.doi.org/10.3390/cancers11071000 |
_version_ | 1783441028077846528 |
---|---|
author | Chen, Viola J. Hernandez-Meza, Gabriela Agrawal, Prashasti Zhang, Chiyuan A. Xie, Lijia Gong, Cynthia L. Hoerner, Christian R. Srinivas, Sandy Oermann, Eric K. Fan, Alice C. |
author_facet | Chen, Viola J. Hernandez-Meza, Gabriela Agrawal, Prashasti Zhang, Chiyuan A. Xie, Lijia Gong, Cynthia L. Hoerner, Christian R. Srinivas, Sandy Oermann, Eric K. Fan, Alice C. |
author_sort | Chen, Viola J. |
collection | PubMed |
description | With 15 drugs currently approved for the treatment of metastatic renal cell carcinoma (mRCC) and even more combination regimens with immunotherapy on the horizon, there remains a distinct lack of molecular biomarkers for therapeutic efficacy. Our study reports on real-world clinical outcomes of mRCC patients from a tertiary academic medical center treated with empirically selected standard-of-care therapy. We utilized the Stanford Renal Cell Carcinoma Database (RCCD) to report on various outcome measures, including overall survival (OS) and the median number of lines of targeted therapies received from the time of metastatic diagnosis. We found that most metastatic patients did not survive long enough to attempt even half of the available targeted therapies. We also noted that patients who failed to receive a clinical benefit within the first two lines of therapy could still go on to experience clinical benefit in later lines of therapy. The term, “clinical benefit” was assigned to a line of therapy if a patient remained on drug treatment for three months or longer. Moreover, patients with clinical benefit in at least one line of therapy experienced significantly longer OS compared to those who did not have clinical benefit in at least one line of therapy. Developing biomarkers that identify patients who will receive clinical benefit in individual lines of therapy is one potential strategy for achieving rational drug sequencing in mRCC. |
format | Online Article Text |
id | pubmed-6678132 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-66781322019-08-19 Time on Therapy for at Least Three Months Correlates with Overall Survival in Metastatic Renal Cell Carcinoma Chen, Viola J. Hernandez-Meza, Gabriela Agrawal, Prashasti Zhang, Chiyuan A. Xie, Lijia Gong, Cynthia L. Hoerner, Christian R. Srinivas, Sandy Oermann, Eric K. Fan, Alice C. Cancers (Basel) Article With 15 drugs currently approved for the treatment of metastatic renal cell carcinoma (mRCC) and even more combination regimens with immunotherapy on the horizon, there remains a distinct lack of molecular biomarkers for therapeutic efficacy. Our study reports on real-world clinical outcomes of mRCC patients from a tertiary academic medical center treated with empirically selected standard-of-care therapy. We utilized the Stanford Renal Cell Carcinoma Database (RCCD) to report on various outcome measures, including overall survival (OS) and the median number of lines of targeted therapies received from the time of metastatic diagnosis. We found that most metastatic patients did not survive long enough to attempt even half of the available targeted therapies. We also noted that patients who failed to receive a clinical benefit within the first two lines of therapy could still go on to experience clinical benefit in later lines of therapy. The term, “clinical benefit” was assigned to a line of therapy if a patient remained on drug treatment for three months or longer. Moreover, patients with clinical benefit in at least one line of therapy experienced significantly longer OS compared to those who did not have clinical benefit in at least one line of therapy. Developing biomarkers that identify patients who will receive clinical benefit in individual lines of therapy is one potential strategy for achieving rational drug sequencing in mRCC. MDPI 2019-07-17 /pmc/articles/PMC6678132/ /pubmed/31319594 http://dx.doi.org/10.3390/cancers11071000 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Chen, Viola J. Hernandez-Meza, Gabriela Agrawal, Prashasti Zhang, Chiyuan A. Xie, Lijia Gong, Cynthia L. Hoerner, Christian R. Srinivas, Sandy Oermann, Eric K. Fan, Alice C. Time on Therapy for at Least Three Months Correlates with Overall Survival in Metastatic Renal Cell Carcinoma |
title | Time on Therapy for at Least Three Months Correlates with Overall Survival in Metastatic Renal Cell Carcinoma |
title_full | Time on Therapy for at Least Three Months Correlates with Overall Survival in Metastatic Renal Cell Carcinoma |
title_fullStr | Time on Therapy for at Least Three Months Correlates with Overall Survival in Metastatic Renal Cell Carcinoma |
title_full_unstemmed | Time on Therapy for at Least Three Months Correlates with Overall Survival in Metastatic Renal Cell Carcinoma |
title_short | Time on Therapy for at Least Three Months Correlates with Overall Survival in Metastatic Renal Cell Carcinoma |
title_sort | time on therapy for at least three months correlates with overall survival in metastatic renal cell carcinoma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678132/ https://www.ncbi.nlm.nih.gov/pubmed/31319594 http://dx.doi.org/10.3390/cancers11071000 |
work_keys_str_mv | AT chenviolaj timeontherapyforatleastthreemonthscorrelateswithoverallsurvivalinmetastaticrenalcellcarcinoma AT hernandezmezagabriela timeontherapyforatleastthreemonthscorrelateswithoverallsurvivalinmetastaticrenalcellcarcinoma AT agrawalprashasti timeontherapyforatleastthreemonthscorrelateswithoverallsurvivalinmetastaticrenalcellcarcinoma AT zhangchiyuana timeontherapyforatleastthreemonthscorrelateswithoverallsurvivalinmetastaticrenalcellcarcinoma AT xielijia timeontherapyforatleastthreemonthscorrelateswithoverallsurvivalinmetastaticrenalcellcarcinoma AT gongcynthial timeontherapyforatleastthreemonthscorrelateswithoverallsurvivalinmetastaticrenalcellcarcinoma AT hoernerchristianr timeontherapyforatleastthreemonthscorrelateswithoverallsurvivalinmetastaticrenalcellcarcinoma AT srinivassandy timeontherapyforatleastthreemonthscorrelateswithoverallsurvivalinmetastaticrenalcellcarcinoma AT oermannerick timeontherapyforatleastthreemonthscorrelateswithoverallsurvivalinmetastaticrenalcellcarcinoma AT fanalicec timeontherapyforatleastthreemonthscorrelateswithoverallsurvivalinmetastaticrenalcellcarcinoma |