Cargando…

A Comprehensive Review of Autophagy and Its Various Roles in Infectious, Non-Infectious, and Lifestyle Diseases: Current Knowledge and Prospects for Disease Prevention, Novel Drug Design, and Therapy

Autophagy (self-eating) is a conserved cellular degradation process that plays important roles in maintaining homeostasis and preventing nutritional, metabolic, and infection-mediated stresses. Autophagy dysfunction can have various pathological consequences, including tumor progression, pathogen hy...

Descripción completa

Detalles Bibliográficos
Autores principales: Khandia, Rekha, Dadar, Maryam, Munjal, Ashok, Dhama, Kuldeep, Karthik, Kumaragurubaran, Tiwari, Ruchi, Yatoo, Mohd. Iqbal, Iqbal, Hafiz M.N., Singh, Karam Pal, Joshi, Sunil K., Chaicumpa, Wanpen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678135/
https://www.ncbi.nlm.nih.gov/pubmed/31277291
http://dx.doi.org/10.3390/cells8070674
_version_ 1783441028762566656
author Khandia, Rekha
Dadar, Maryam
Munjal, Ashok
Dhama, Kuldeep
Karthik, Kumaragurubaran
Tiwari, Ruchi
Yatoo, Mohd. Iqbal
Iqbal, Hafiz M.N.
Singh, Karam Pal
Joshi, Sunil K.
Chaicumpa, Wanpen
author_facet Khandia, Rekha
Dadar, Maryam
Munjal, Ashok
Dhama, Kuldeep
Karthik, Kumaragurubaran
Tiwari, Ruchi
Yatoo, Mohd. Iqbal
Iqbal, Hafiz M.N.
Singh, Karam Pal
Joshi, Sunil K.
Chaicumpa, Wanpen
author_sort Khandia, Rekha
collection PubMed
description Autophagy (self-eating) is a conserved cellular degradation process that plays important roles in maintaining homeostasis and preventing nutritional, metabolic, and infection-mediated stresses. Autophagy dysfunction can have various pathological consequences, including tumor progression, pathogen hyper-virulence, and neurodegeneration. This review describes the mechanisms of autophagy and its associations with other cell death mechanisms, including apoptosis, necrosis, necroptosis, and autosis. Autophagy has both positive and negative roles in infection, cancer, neural development, metabolism, cardiovascular health, immunity, and iron homeostasis. Genetic defects in autophagy can have pathological consequences, such as static childhood encephalopathy with neurodegeneration in adulthood, Crohn’s disease, hereditary spastic paraparesis, Danon disease, X-linked myopathy with excessive autophagy, and sporadic inclusion body myositis. Further studies on the process of autophagy in different microbial infections could help to design and develop novel therapeutic strategies against important pathogenic microbes. This review on the progress and prospects of autophagy research describes various activators and suppressors, which could be used to design novel intervention strategies against numerous diseases and develop therapeutic drugs to protect human and animal health.
format Online
Article
Text
id pubmed-6678135
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-66781352019-08-19 A Comprehensive Review of Autophagy and Its Various Roles in Infectious, Non-Infectious, and Lifestyle Diseases: Current Knowledge and Prospects for Disease Prevention, Novel Drug Design, and Therapy Khandia, Rekha Dadar, Maryam Munjal, Ashok Dhama, Kuldeep Karthik, Kumaragurubaran Tiwari, Ruchi Yatoo, Mohd. Iqbal Iqbal, Hafiz M.N. Singh, Karam Pal Joshi, Sunil K. Chaicumpa, Wanpen Cells Review Autophagy (self-eating) is a conserved cellular degradation process that plays important roles in maintaining homeostasis and preventing nutritional, metabolic, and infection-mediated stresses. Autophagy dysfunction can have various pathological consequences, including tumor progression, pathogen hyper-virulence, and neurodegeneration. This review describes the mechanisms of autophagy and its associations with other cell death mechanisms, including apoptosis, necrosis, necroptosis, and autosis. Autophagy has both positive and negative roles in infection, cancer, neural development, metabolism, cardiovascular health, immunity, and iron homeostasis. Genetic defects in autophagy can have pathological consequences, such as static childhood encephalopathy with neurodegeneration in adulthood, Crohn’s disease, hereditary spastic paraparesis, Danon disease, X-linked myopathy with excessive autophagy, and sporadic inclusion body myositis. Further studies on the process of autophagy in different microbial infections could help to design and develop novel therapeutic strategies against important pathogenic microbes. This review on the progress and prospects of autophagy research describes various activators and suppressors, which could be used to design novel intervention strategies against numerous diseases and develop therapeutic drugs to protect human and animal health. MDPI 2019-07-03 /pmc/articles/PMC6678135/ /pubmed/31277291 http://dx.doi.org/10.3390/cells8070674 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Khandia, Rekha
Dadar, Maryam
Munjal, Ashok
Dhama, Kuldeep
Karthik, Kumaragurubaran
Tiwari, Ruchi
Yatoo, Mohd. Iqbal
Iqbal, Hafiz M.N.
Singh, Karam Pal
Joshi, Sunil K.
Chaicumpa, Wanpen
A Comprehensive Review of Autophagy and Its Various Roles in Infectious, Non-Infectious, and Lifestyle Diseases: Current Knowledge and Prospects for Disease Prevention, Novel Drug Design, and Therapy
title A Comprehensive Review of Autophagy and Its Various Roles in Infectious, Non-Infectious, and Lifestyle Diseases: Current Knowledge and Prospects for Disease Prevention, Novel Drug Design, and Therapy
title_full A Comprehensive Review of Autophagy and Its Various Roles in Infectious, Non-Infectious, and Lifestyle Diseases: Current Knowledge and Prospects for Disease Prevention, Novel Drug Design, and Therapy
title_fullStr A Comprehensive Review of Autophagy and Its Various Roles in Infectious, Non-Infectious, and Lifestyle Diseases: Current Knowledge and Prospects for Disease Prevention, Novel Drug Design, and Therapy
title_full_unstemmed A Comprehensive Review of Autophagy and Its Various Roles in Infectious, Non-Infectious, and Lifestyle Diseases: Current Knowledge and Prospects for Disease Prevention, Novel Drug Design, and Therapy
title_short A Comprehensive Review of Autophagy and Its Various Roles in Infectious, Non-Infectious, and Lifestyle Diseases: Current Knowledge and Prospects for Disease Prevention, Novel Drug Design, and Therapy
title_sort comprehensive review of autophagy and its various roles in infectious, non-infectious, and lifestyle diseases: current knowledge and prospects for disease prevention, novel drug design, and therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678135/
https://www.ncbi.nlm.nih.gov/pubmed/31277291
http://dx.doi.org/10.3390/cells8070674
work_keys_str_mv AT khandiarekha acomprehensivereviewofautophagyanditsvariousrolesininfectiousnoninfectiousandlifestylediseasescurrentknowledgeandprospectsfordiseasepreventionnoveldrugdesignandtherapy
AT dadarmaryam acomprehensivereviewofautophagyanditsvariousrolesininfectiousnoninfectiousandlifestylediseasescurrentknowledgeandprospectsfordiseasepreventionnoveldrugdesignandtherapy
AT munjalashok acomprehensivereviewofautophagyanditsvariousrolesininfectiousnoninfectiousandlifestylediseasescurrentknowledgeandprospectsfordiseasepreventionnoveldrugdesignandtherapy
AT dhamakuldeep acomprehensivereviewofautophagyanditsvariousrolesininfectiousnoninfectiousandlifestylediseasescurrentknowledgeandprospectsfordiseasepreventionnoveldrugdesignandtherapy
AT karthikkumaragurubaran acomprehensivereviewofautophagyanditsvariousrolesininfectiousnoninfectiousandlifestylediseasescurrentknowledgeandprospectsfordiseasepreventionnoveldrugdesignandtherapy
AT tiwariruchi acomprehensivereviewofautophagyanditsvariousrolesininfectiousnoninfectiousandlifestylediseasescurrentknowledgeandprospectsfordiseasepreventionnoveldrugdesignandtherapy
AT yatoomohdiqbal acomprehensivereviewofautophagyanditsvariousrolesininfectiousnoninfectiousandlifestylediseasescurrentknowledgeandprospectsfordiseasepreventionnoveldrugdesignandtherapy
AT iqbalhafizmn acomprehensivereviewofautophagyanditsvariousrolesininfectiousnoninfectiousandlifestylediseasescurrentknowledgeandprospectsfordiseasepreventionnoveldrugdesignandtherapy
AT singhkarampal acomprehensivereviewofautophagyanditsvariousrolesininfectiousnoninfectiousandlifestylediseasescurrentknowledgeandprospectsfordiseasepreventionnoveldrugdesignandtherapy
AT joshisunilk acomprehensivereviewofautophagyanditsvariousrolesininfectiousnoninfectiousandlifestylediseasescurrentknowledgeandprospectsfordiseasepreventionnoveldrugdesignandtherapy
AT chaicumpawanpen acomprehensivereviewofautophagyanditsvariousrolesininfectiousnoninfectiousandlifestylediseasescurrentknowledgeandprospectsfordiseasepreventionnoveldrugdesignandtherapy
AT khandiarekha comprehensivereviewofautophagyanditsvariousrolesininfectiousnoninfectiousandlifestylediseasescurrentknowledgeandprospectsfordiseasepreventionnoveldrugdesignandtherapy
AT dadarmaryam comprehensivereviewofautophagyanditsvariousrolesininfectiousnoninfectiousandlifestylediseasescurrentknowledgeandprospectsfordiseasepreventionnoveldrugdesignandtherapy
AT munjalashok comprehensivereviewofautophagyanditsvariousrolesininfectiousnoninfectiousandlifestylediseasescurrentknowledgeandprospectsfordiseasepreventionnoveldrugdesignandtherapy
AT dhamakuldeep comprehensivereviewofautophagyanditsvariousrolesininfectiousnoninfectiousandlifestylediseasescurrentknowledgeandprospectsfordiseasepreventionnoveldrugdesignandtherapy
AT karthikkumaragurubaran comprehensivereviewofautophagyanditsvariousrolesininfectiousnoninfectiousandlifestylediseasescurrentknowledgeandprospectsfordiseasepreventionnoveldrugdesignandtherapy
AT tiwariruchi comprehensivereviewofautophagyanditsvariousrolesininfectiousnoninfectiousandlifestylediseasescurrentknowledgeandprospectsfordiseasepreventionnoveldrugdesignandtherapy
AT yatoomohdiqbal comprehensivereviewofautophagyanditsvariousrolesininfectiousnoninfectiousandlifestylediseasescurrentknowledgeandprospectsfordiseasepreventionnoveldrugdesignandtherapy
AT iqbalhafizmn comprehensivereviewofautophagyanditsvariousrolesininfectiousnoninfectiousandlifestylediseasescurrentknowledgeandprospectsfordiseasepreventionnoveldrugdesignandtherapy
AT singhkarampal comprehensivereviewofautophagyanditsvariousrolesininfectiousnoninfectiousandlifestylediseasescurrentknowledgeandprospectsfordiseasepreventionnoveldrugdesignandtherapy
AT joshisunilk comprehensivereviewofautophagyanditsvariousrolesininfectiousnoninfectiousandlifestylediseasescurrentknowledgeandprospectsfordiseasepreventionnoveldrugdesignandtherapy
AT chaicumpawanpen comprehensivereviewofautophagyanditsvariousrolesininfectiousnoninfectiousandlifestylediseasescurrentknowledgeandprospectsfordiseasepreventionnoveldrugdesignandtherapy