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Severity of Coronary Atherosclerosis and Risk of Diabetes Mellitus

Background: Cardio-vascular target organ damage predicts the onset of type 2 diabetes mellitus (DM) in hypertensive patients. Whether an increased incidence of DM is also in relation to the severity of coronary atherosclerosis is unknown. Objective: We evaluated the onset of DM in relation to the ex...

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Autores principales: Colaiori, Iginio, Izzo, Raffaele, Barbato, Emanuele, Franco, Danilo, Di Gioia, Giuseppe, Rapacciuolo, Antonio, Bartunek, Jozef, Mancusi, Costantino, Losi, Maria Angela, Strisciuglio, Teresa, Manzi, Maria Virginia, de Simone, Giovanni, Trimarco, Bruno, Morisco, Carmine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678313/
https://www.ncbi.nlm.nih.gov/pubmed/31330868
http://dx.doi.org/10.3390/jcm8071069
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author Colaiori, Iginio
Izzo, Raffaele
Barbato, Emanuele
Franco, Danilo
Di Gioia, Giuseppe
Rapacciuolo, Antonio
Bartunek, Jozef
Mancusi, Costantino
Losi, Maria Angela
Strisciuglio, Teresa
Manzi, Maria Virginia
de Simone, Giovanni
Trimarco, Bruno
Morisco, Carmine
author_facet Colaiori, Iginio
Izzo, Raffaele
Barbato, Emanuele
Franco, Danilo
Di Gioia, Giuseppe
Rapacciuolo, Antonio
Bartunek, Jozef
Mancusi, Costantino
Losi, Maria Angela
Strisciuglio, Teresa
Manzi, Maria Virginia
de Simone, Giovanni
Trimarco, Bruno
Morisco, Carmine
author_sort Colaiori, Iginio
collection PubMed
description Background: Cardio-vascular target organ damage predicts the onset of type 2 diabetes mellitus (DM) in hypertensive patients. Whether an increased incidence of DM is also in relation to the severity of coronary atherosclerosis is unknown. Objective: We evaluated the onset of DM in relation to the extent and severity of coronary atherosclerosis, using the SYNTAX (Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery) score (SS), in patients with stable angina or acute coronary syndromes, referred for coronary angiography (CA). Methods: Non-diabetic patients that underwent CA for the first time were included, and the SS was computed. Predictors of DM onset in low, medium, and high SSs were investigated. Results: Five hundred and seventy patients were included, and the mean SS was 6.3 ± 7.6. During a median follow-up of 79 months (interquartile range (IQR): 67–94), 74 patients (13%) developed DM. The risk of DM onset was significantly higher in the patients with a medium or high SS (hazard ratio (HR)—95% confidence interval (CI): 16 (4–61), p < 0.0001; and 30 (9–105), p < 0.0001, vs low SS, respectively), even after adjustment for obesity, history of hypertension, impaired fasting glucose, and cardiovascular therapy. Conclusions: The severity and extent of the coronary atherosclerosis, evaluated by the SS, is a strong and independent predictor of the development of DM in patients, referred to CA.
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spelling pubmed-66783132019-08-19 Severity of Coronary Atherosclerosis and Risk of Diabetes Mellitus Colaiori, Iginio Izzo, Raffaele Barbato, Emanuele Franco, Danilo Di Gioia, Giuseppe Rapacciuolo, Antonio Bartunek, Jozef Mancusi, Costantino Losi, Maria Angela Strisciuglio, Teresa Manzi, Maria Virginia de Simone, Giovanni Trimarco, Bruno Morisco, Carmine J Clin Med Article Background: Cardio-vascular target organ damage predicts the onset of type 2 diabetes mellitus (DM) in hypertensive patients. Whether an increased incidence of DM is also in relation to the severity of coronary atherosclerosis is unknown. Objective: We evaluated the onset of DM in relation to the extent and severity of coronary atherosclerosis, using the SYNTAX (Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery) score (SS), in patients with stable angina or acute coronary syndromes, referred for coronary angiography (CA). Methods: Non-diabetic patients that underwent CA for the first time were included, and the SS was computed. Predictors of DM onset in low, medium, and high SSs were investigated. Results: Five hundred and seventy patients were included, and the mean SS was 6.3 ± 7.6. During a median follow-up of 79 months (interquartile range (IQR): 67–94), 74 patients (13%) developed DM. The risk of DM onset was significantly higher in the patients with a medium or high SS (hazard ratio (HR)—95% confidence interval (CI): 16 (4–61), p < 0.0001; and 30 (9–105), p < 0.0001, vs low SS, respectively), even after adjustment for obesity, history of hypertension, impaired fasting glucose, and cardiovascular therapy. Conclusions: The severity and extent of the coronary atherosclerosis, evaluated by the SS, is a strong and independent predictor of the development of DM in patients, referred to CA. MDPI 2019-07-21 /pmc/articles/PMC6678313/ /pubmed/31330868 http://dx.doi.org/10.3390/jcm8071069 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Colaiori, Iginio
Izzo, Raffaele
Barbato, Emanuele
Franco, Danilo
Di Gioia, Giuseppe
Rapacciuolo, Antonio
Bartunek, Jozef
Mancusi, Costantino
Losi, Maria Angela
Strisciuglio, Teresa
Manzi, Maria Virginia
de Simone, Giovanni
Trimarco, Bruno
Morisco, Carmine
Severity of Coronary Atherosclerosis and Risk of Diabetes Mellitus
title Severity of Coronary Atherosclerosis and Risk of Diabetes Mellitus
title_full Severity of Coronary Atherosclerosis and Risk of Diabetes Mellitus
title_fullStr Severity of Coronary Atherosclerosis and Risk of Diabetes Mellitus
title_full_unstemmed Severity of Coronary Atherosclerosis and Risk of Diabetes Mellitus
title_short Severity of Coronary Atherosclerosis and Risk of Diabetes Mellitus
title_sort severity of coronary atherosclerosis and risk of diabetes mellitus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678313/
https://www.ncbi.nlm.nih.gov/pubmed/31330868
http://dx.doi.org/10.3390/jcm8071069
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