The Antiviral Agent Cidofovir Induces DNA Damage and Mitotic Catastrophe in HPV-Positive and -Negative Head and Neck Squamous Cell Carcinomas In Vitro

Cidofovir (CDV) is an antiviral agent with antiproliferative properties. The aim of our study was to investigate the efficacy of CDV in HPV-positive and -negative head and neck squamous cell carcinoma (HNSCC) cell lines and whether it is caused by a difference in response to DNA damage. Upon CDV tre...

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Detalles Bibliográficos
Autores principales: Verhees, Femke, Legemaate, Dion, Demers, Imke, Jacobs, Robin, Haakma, Wisse Evert, Rousch, Mat, Kremer, Bernd, Speel, Ernst Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678333/
https://www.ncbi.nlm.nih.gov/pubmed/31262012
http://dx.doi.org/10.3390/cancers11070919

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