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Comparison of Glucose Tolerance between Kidney Transplant Recipients and Healthy Controls

Post-transplant hyperglycemia and new-onset diabetes mellitus after transplantation (NODAT) are common and important metabolic complications. Decreased insulin secretion and increased insulin resistance are important to the pathophysiologic mechanism behind NODAT. However, the progression of glucose...

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Autores principales: Shimada, Hisao, Uchida, Junji, Nishide, Shunji, Kabei, Kazuya, Kosoku, Akihiro, Maeda, Keiko, Iwai, Tomoaki, Naganuma, Toshihide, Takemoto, Yoshiaki, Nakatani, Tatsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678426/
https://www.ncbi.nlm.nih.gov/pubmed/31252561
http://dx.doi.org/10.3390/jcm8070920
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author Shimada, Hisao
Uchida, Junji
Nishide, Shunji
Kabei, Kazuya
Kosoku, Akihiro
Maeda, Keiko
Iwai, Tomoaki
Naganuma, Toshihide
Takemoto, Yoshiaki
Nakatani, Tatsuya
author_facet Shimada, Hisao
Uchida, Junji
Nishide, Shunji
Kabei, Kazuya
Kosoku, Akihiro
Maeda, Keiko
Iwai, Tomoaki
Naganuma, Toshihide
Takemoto, Yoshiaki
Nakatani, Tatsuya
author_sort Shimada, Hisao
collection PubMed
description Post-transplant hyperglycemia and new-onset diabetes mellitus after transplantation (NODAT) are common and important metabolic complications. Decreased insulin secretion and increased insulin resistance are important to the pathophysiologic mechanism behind NODAT. However, the progression of glucose intolerance diagnosed late after kidney transplantation remains clearly unknown. Enrolled in this study were 94 kidney transplant recipients and 134 kidney transplant donors, as the healthy controls, who were treated at our institution. The 75 g-oral glucose tolerance test (OGTT) was performed in the recipients, and the healthy controls received an OGTT before donor nephrectomy. We assessed the prevalence of glucose intolerance including impaired fasting glucose and/or impaired glucose tolerance, as well as insulin secretion and insulin resistance using the homeostasis model assessment, and compared the results between the two groups. Multivariate analysis after adjustment for age, gender, body mass index, estimated glomerular filtration rate, and systolic blood pressure showed that the prevalence of glucose intolerance, insulin resistance, insulin secretion, and 2 h plasma glucose levels were significantly higher in the kidney transplant recipients compared to the healthy controls. Elevation of insulin secretion in kidney transplant recipients may be compensatory for increase of insulin resistance. Impaired compensatory pancreas β cell function may lead to glucose intolerance and NODAT in the future.
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spelling pubmed-66784262019-08-19 Comparison of Glucose Tolerance between Kidney Transplant Recipients and Healthy Controls Shimada, Hisao Uchida, Junji Nishide, Shunji Kabei, Kazuya Kosoku, Akihiro Maeda, Keiko Iwai, Tomoaki Naganuma, Toshihide Takemoto, Yoshiaki Nakatani, Tatsuya J Clin Med Article Post-transplant hyperglycemia and new-onset diabetes mellitus after transplantation (NODAT) are common and important metabolic complications. Decreased insulin secretion and increased insulin resistance are important to the pathophysiologic mechanism behind NODAT. However, the progression of glucose intolerance diagnosed late after kidney transplantation remains clearly unknown. Enrolled in this study were 94 kidney transplant recipients and 134 kidney transplant donors, as the healthy controls, who were treated at our institution. The 75 g-oral glucose tolerance test (OGTT) was performed in the recipients, and the healthy controls received an OGTT before donor nephrectomy. We assessed the prevalence of glucose intolerance including impaired fasting glucose and/or impaired glucose tolerance, as well as insulin secretion and insulin resistance using the homeostasis model assessment, and compared the results between the two groups. Multivariate analysis after adjustment for age, gender, body mass index, estimated glomerular filtration rate, and systolic blood pressure showed that the prevalence of glucose intolerance, insulin resistance, insulin secretion, and 2 h plasma glucose levels were significantly higher in the kidney transplant recipients compared to the healthy controls. Elevation of insulin secretion in kidney transplant recipients may be compensatory for increase of insulin resistance. Impaired compensatory pancreas β cell function may lead to glucose intolerance and NODAT in the future. MDPI 2019-06-27 /pmc/articles/PMC6678426/ /pubmed/31252561 http://dx.doi.org/10.3390/jcm8070920 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shimada, Hisao
Uchida, Junji
Nishide, Shunji
Kabei, Kazuya
Kosoku, Akihiro
Maeda, Keiko
Iwai, Tomoaki
Naganuma, Toshihide
Takemoto, Yoshiaki
Nakatani, Tatsuya
Comparison of Glucose Tolerance between Kidney Transplant Recipients and Healthy Controls
title Comparison of Glucose Tolerance between Kidney Transplant Recipients and Healthy Controls
title_full Comparison of Glucose Tolerance between Kidney Transplant Recipients and Healthy Controls
title_fullStr Comparison of Glucose Tolerance between Kidney Transplant Recipients and Healthy Controls
title_full_unstemmed Comparison of Glucose Tolerance between Kidney Transplant Recipients and Healthy Controls
title_short Comparison of Glucose Tolerance between Kidney Transplant Recipients and Healthy Controls
title_sort comparison of glucose tolerance between kidney transplant recipients and healthy controls
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678426/
https://www.ncbi.nlm.nih.gov/pubmed/31252561
http://dx.doi.org/10.3390/jcm8070920
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