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CCR5 Promoter Polymorphism −2459G > A: Forgotten or Ignored?

C-C chemokine receptor 5 (CCR5) polymorphisms, particularly a 32-base pair deletion (∆32) in the open reading frame and −2459G > A in the promoter, are well known for their associations with HIV-1 infection and/or disease progression in a variety of studies. In this era of an HIV cure, where all...

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Autor principal: Mehlotra, Rajeev K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678430/
https://www.ncbi.nlm.nih.gov/pubmed/31261839
http://dx.doi.org/10.3390/cells8070651
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author Mehlotra, Rajeev K.
author_facet Mehlotra, Rajeev K.
author_sort Mehlotra, Rajeev K.
collection PubMed
description C-C chemokine receptor 5 (CCR5) polymorphisms, particularly a 32-base pair deletion (∆32) in the open reading frame and −2459G > A in the promoter, are well known for their associations with HIV-1 infection and/or disease progression in a variety of studies. In this era of an HIV cure, where all the emphasis is on ∆32, it seems that −2459G > A has been forgotten or ignored. There is significant importance in the incorporation of the CCR5 −2459G > A genotype information into studies evaluating new immunologic and chemotherapeutic strategies, and those designing and implementing better treatment strategies with current antiretroviral therapy, doing so would enable a better understanding of the response to the intervention, due to a mechanistic or constitutive explanation. Until we find a strategy, whether a stem-cell transplantation or CCR5 editing approach or something else, that delivers a cure to the millions, we should make use of every piece of information that may help curtail HIV/AIDS as a threat to public health.
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spelling pubmed-66784302019-08-19 CCR5 Promoter Polymorphism −2459G > A: Forgotten or Ignored? Mehlotra, Rajeev K. Cells Viewpoint C-C chemokine receptor 5 (CCR5) polymorphisms, particularly a 32-base pair deletion (∆32) in the open reading frame and −2459G > A in the promoter, are well known for their associations with HIV-1 infection and/or disease progression in a variety of studies. In this era of an HIV cure, where all the emphasis is on ∆32, it seems that −2459G > A has been forgotten or ignored. There is significant importance in the incorporation of the CCR5 −2459G > A genotype information into studies evaluating new immunologic and chemotherapeutic strategies, and those designing and implementing better treatment strategies with current antiretroviral therapy, doing so would enable a better understanding of the response to the intervention, due to a mechanistic or constitutive explanation. Until we find a strategy, whether a stem-cell transplantation or CCR5 editing approach or something else, that delivers a cure to the millions, we should make use of every piece of information that may help curtail HIV/AIDS as a threat to public health. MDPI 2019-06-28 /pmc/articles/PMC6678430/ /pubmed/31261839 http://dx.doi.org/10.3390/cells8070651 Text en © 2019 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Viewpoint
Mehlotra, Rajeev K.
CCR5 Promoter Polymorphism −2459G > A: Forgotten or Ignored?
title CCR5 Promoter Polymorphism −2459G > A: Forgotten or Ignored?
title_full CCR5 Promoter Polymorphism −2459G > A: Forgotten or Ignored?
title_fullStr CCR5 Promoter Polymorphism −2459G > A: Forgotten or Ignored?
title_full_unstemmed CCR5 Promoter Polymorphism −2459G > A: Forgotten or Ignored?
title_short CCR5 Promoter Polymorphism −2459G > A: Forgotten or Ignored?
title_sort ccr5 promoter polymorphism −2459g > a: forgotten or ignored?
topic Viewpoint
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678430/
https://www.ncbi.nlm.nih.gov/pubmed/31261839
http://dx.doi.org/10.3390/cells8070651
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