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The Role of Cysteine Cathepsins in Cancer Progression and Drug Resistance
Cysteine cathepsins are lysosomal enzymes belonging to the papain family. Their expression is misregulated in a wide variety of tumors, and ample data prove their involvement in cancer progression, angiogenesis, metastasis, and in the occurrence of drug resistance. However, while their overexpressio...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678516/ https://www.ncbi.nlm.nih.gov/pubmed/31340550 http://dx.doi.org/10.3390/ijms20143602 |
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| author | Rudzińska, Magdalena Parodi, Alessandro Soond, Surinder M. Vinarov, Andrey Z. Korolev, Dmitry O. Morozov, Andrey O. Daglioglu, Cenk Tutar, Yusuf Zamyatnin, Andrey A. |
| author_facet | Rudzińska, Magdalena Parodi, Alessandro Soond, Surinder M. Vinarov, Andrey Z. Korolev, Dmitry O. Morozov, Andrey O. Daglioglu, Cenk Tutar, Yusuf Zamyatnin, Andrey A. |
| author_sort | Rudzińska, Magdalena |
| collection | PubMed |
| description | Cysteine cathepsins are lysosomal enzymes belonging to the papain family. Their expression is misregulated in a wide variety of tumors, and ample data prove their involvement in cancer progression, angiogenesis, metastasis, and in the occurrence of drug resistance. However, while their overexpression is usually associated with highly aggressive tumor phenotypes, their mechanistic role in cancer progression is still to be determined to develop new therapeutic strategies. In this review, we highlight the literature related to the role of the cysteine cathepsins in cancer biology, with particular emphasis on their input into tumor biology. |
| format | Online Article Text |
| id | pubmed-6678516 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-66785162019-08-19 The Role of Cysteine Cathepsins in Cancer Progression and Drug Resistance Rudzińska, Magdalena Parodi, Alessandro Soond, Surinder M. Vinarov, Andrey Z. Korolev, Dmitry O. Morozov, Andrey O. Daglioglu, Cenk Tutar, Yusuf Zamyatnin, Andrey A. Int J Mol Sci Review Cysteine cathepsins are lysosomal enzymes belonging to the papain family. Their expression is misregulated in a wide variety of tumors, and ample data prove their involvement in cancer progression, angiogenesis, metastasis, and in the occurrence of drug resistance. However, while their overexpression is usually associated with highly aggressive tumor phenotypes, their mechanistic role in cancer progression is still to be determined to develop new therapeutic strategies. In this review, we highlight the literature related to the role of the cysteine cathepsins in cancer biology, with particular emphasis on their input into tumor biology. MDPI 2019-07-23 /pmc/articles/PMC6678516/ /pubmed/31340550 http://dx.doi.org/10.3390/ijms20143602 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Review Rudzińska, Magdalena Parodi, Alessandro Soond, Surinder M. Vinarov, Andrey Z. Korolev, Dmitry O. Morozov, Andrey O. Daglioglu, Cenk Tutar, Yusuf Zamyatnin, Andrey A. The Role of Cysteine Cathepsins in Cancer Progression and Drug Resistance |
| title | The Role of Cysteine Cathepsins in Cancer Progression and Drug Resistance |
| title_full | The Role of Cysteine Cathepsins in Cancer Progression and Drug Resistance |
| title_fullStr | The Role of Cysteine Cathepsins in Cancer Progression and Drug Resistance |
| title_full_unstemmed | The Role of Cysteine Cathepsins in Cancer Progression and Drug Resistance |
| title_short | The Role of Cysteine Cathepsins in Cancer Progression and Drug Resistance |
| title_sort | role of cysteine cathepsins in cancer progression and drug resistance |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678516/ https://www.ncbi.nlm.nih.gov/pubmed/31340550 http://dx.doi.org/10.3390/ijms20143602 |
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