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Mitochondrial Involvement in Cisplatin Resistance
Cisplatin is one of the worldwide anticancer drugs and, despite its toxicity and frequent recurrence of resistance phenomena, it still remains the only therapeutic option for several tumors. Circumventing cisplatin resistance remains, therefore, a major goal for clinical therapy and represents a cha...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678541/ https://www.ncbi.nlm.nih.gov/pubmed/31295873 http://dx.doi.org/10.3390/ijms20143384 |
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author | Cocetta, Veronica Ragazzi, Eugenio Montopoli, Monica |
author_facet | Cocetta, Veronica Ragazzi, Eugenio Montopoli, Monica |
author_sort | Cocetta, Veronica |
collection | PubMed |
description | Cisplatin is one of the worldwide anticancer drugs and, despite its toxicity and frequent recurrence of resistance phenomena, it still remains the only therapeutic option for several tumors. Circumventing cisplatin resistance remains, therefore, a major goal for clinical therapy and represents a challenge for scientific research. Recent studies have brought to light the fundamental role of mitochondria in onset, progression, and metastasis of cancer, as well as its importance in the resistance to chemotherapy. The aim of this review is to give an overview of the current knowledge about the implication of mitochondria in cisplatin resistance and on the recent development in this research field. Recent studies have highlighted the role of mitochondrial DNA alterations in onset of resistance phenomena, being related both to redox balance alterations and to signal crosstalk with the nucleus, allowing a rewiring of cell metabolism. Moreover, an important role of the mitochondrial dynamics in the adaptation mechanism of cancer cells to challenging environment has been revealed. Giving bioenergetic plasticity to tumor cells, mitochondria allow cells to evade death pathways in stressful conditions, including chemotherapy. So far, even if the central role of mitochondria is recognized, little is known about the specific mechanisms implicated in the resistance. Nevertheless, mitochondria appear to be promising pharmacological targets for overcoming cisplatin resistance, but further studies are necessary. |
format | Online Article Text |
id | pubmed-6678541 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-66785412019-08-19 Mitochondrial Involvement in Cisplatin Resistance Cocetta, Veronica Ragazzi, Eugenio Montopoli, Monica Int J Mol Sci Review Cisplatin is one of the worldwide anticancer drugs and, despite its toxicity and frequent recurrence of resistance phenomena, it still remains the only therapeutic option for several tumors. Circumventing cisplatin resistance remains, therefore, a major goal for clinical therapy and represents a challenge for scientific research. Recent studies have brought to light the fundamental role of mitochondria in onset, progression, and metastasis of cancer, as well as its importance in the resistance to chemotherapy. The aim of this review is to give an overview of the current knowledge about the implication of mitochondria in cisplatin resistance and on the recent development in this research field. Recent studies have highlighted the role of mitochondrial DNA alterations in onset of resistance phenomena, being related both to redox balance alterations and to signal crosstalk with the nucleus, allowing a rewiring of cell metabolism. Moreover, an important role of the mitochondrial dynamics in the adaptation mechanism of cancer cells to challenging environment has been revealed. Giving bioenergetic plasticity to tumor cells, mitochondria allow cells to evade death pathways in stressful conditions, including chemotherapy. So far, even if the central role of mitochondria is recognized, little is known about the specific mechanisms implicated in the resistance. Nevertheless, mitochondria appear to be promising pharmacological targets for overcoming cisplatin resistance, but further studies are necessary. MDPI 2019-07-10 /pmc/articles/PMC6678541/ /pubmed/31295873 http://dx.doi.org/10.3390/ijms20143384 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Cocetta, Veronica Ragazzi, Eugenio Montopoli, Monica Mitochondrial Involvement in Cisplatin Resistance |
title | Mitochondrial Involvement in Cisplatin Resistance |
title_full | Mitochondrial Involvement in Cisplatin Resistance |
title_fullStr | Mitochondrial Involvement in Cisplatin Resistance |
title_full_unstemmed | Mitochondrial Involvement in Cisplatin Resistance |
title_short | Mitochondrial Involvement in Cisplatin Resistance |
title_sort | mitochondrial involvement in cisplatin resistance |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678541/ https://www.ncbi.nlm.nih.gov/pubmed/31295873 http://dx.doi.org/10.3390/ijms20143384 |
work_keys_str_mv | AT cocettaveronica mitochondrialinvolvementincisplatinresistance AT ragazzieugenio mitochondrialinvolvementincisplatinresistance AT montopolimonica mitochondrialinvolvementincisplatinresistance |