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Never Travel Alone: The Crosstalk of Circulating Tumor Cells and the Blood Microenvironment
Commonly, circulating tumor cells (CTCs) are described as source of metastasis in cancer patients. However, in this process cancer cells of the primary tumor site need to survive the physical and biological challenges in the blood stream before leaving the circulation to become the seed of a new met...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678604/ https://www.ncbi.nlm.nih.gov/pubmed/31337010 http://dx.doi.org/10.3390/cells8070714 |
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author | Heeke, Simon Mograbi, Baharia Alix-Panabières, Catherine Hofman, Paul |
author_facet | Heeke, Simon Mograbi, Baharia Alix-Panabières, Catherine Hofman, Paul |
author_sort | Heeke, Simon |
collection | PubMed |
description | Commonly, circulating tumor cells (CTCs) are described as source of metastasis in cancer patients. However, in this process cancer cells of the primary tumor site need to survive the physical and biological challenges in the blood stream before leaving the circulation to become the seed of a new metastatic site in distant parenchyma. Most of the CTCs released in the blood stream will not resist those challenges and will consequently fail to induce metastasis. A few of them, however, interact closely with other blood cells, such as neutrophils, platelets, and/or macrophages to survive in the blood stream. Recent studies demonstrated that the interaction and modulation of the blood microenvironment by CTCs is pivotal for the development of new metastasis, making it an interesting target for potential novel treatment strategies. This review will discuss the recent research on the processes in the blood microenvironment with CTCs and will outline currently investigated treatment strategies. |
format | Online Article Text |
id | pubmed-6678604 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-66786042019-08-19 Never Travel Alone: The Crosstalk of Circulating Tumor Cells and the Blood Microenvironment Heeke, Simon Mograbi, Baharia Alix-Panabières, Catherine Hofman, Paul Cells Review Commonly, circulating tumor cells (CTCs) are described as source of metastasis in cancer patients. However, in this process cancer cells of the primary tumor site need to survive the physical and biological challenges in the blood stream before leaving the circulation to become the seed of a new metastatic site in distant parenchyma. Most of the CTCs released in the blood stream will not resist those challenges and will consequently fail to induce metastasis. A few of them, however, interact closely with other blood cells, such as neutrophils, platelets, and/or macrophages to survive in the blood stream. Recent studies demonstrated that the interaction and modulation of the blood microenvironment by CTCs is pivotal for the development of new metastasis, making it an interesting target for potential novel treatment strategies. This review will discuss the recent research on the processes in the blood microenvironment with CTCs and will outline currently investigated treatment strategies. MDPI 2019-07-13 /pmc/articles/PMC6678604/ /pubmed/31337010 http://dx.doi.org/10.3390/cells8070714 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Heeke, Simon Mograbi, Baharia Alix-Panabières, Catherine Hofman, Paul Never Travel Alone: The Crosstalk of Circulating Tumor Cells and the Blood Microenvironment |
title | Never Travel Alone: The Crosstalk of Circulating Tumor Cells and the Blood Microenvironment |
title_full | Never Travel Alone: The Crosstalk of Circulating Tumor Cells and the Blood Microenvironment |
title_fullStr | Never Travel Alone: The Crosstalk of Circulating Tumor Cells and the Blood Microenvironment |
title_full_unstemmed | Never Travel Alone: The Crosstalk of Circulating Tumor Cells and the Blood Microenvironment |
title_short | Never Travel Alone: The Crosstalk of Circulating Tumor Cells and the Blood Microenvironment |
title_sort | never travel alone: the crosstalk of circulating tumor cells and the blood microenvironment |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678604/ https://www.ncbi.nlm.nih.gov/pubmed/31337010 http://dx.doi.org/10.3390/cells8070714 |
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