Mitochondrial Homeostasis and Cellular Senescence

Cellular senescence refers to a stress response aiming to preserve cellular and, therefore, organismal homeostasis. Importantly, deregulation of mitochondrial homeostatic mechanisms, manifested as impaired mitochondrial biogenesis, metabolism and dynamics, has emerged as a hallmark of cellular senes...

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Detalles Bibliográficos
Autores principales: Vasileiou, Panagiotis V.S., Evangelou, Konstantinos, Vlasis, Konstantinos, Fildisis, Georgios, Panayiotidis, Mihalis I., Chronopoulos, Efstathios, Passias, Panagiotis-Georgios, Kouloukoussa, Mirsini, Gorgoulis, Vassilis G., Havaki, Sophia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678662/
https://www.ncbi.nlm.nih.gov/pubmed/31284597
http://dx.doi.org/10.3390/cells8070686
Descripción
Sumario:Cellular senescence refers to a stress response aiming to preserve cellular and, therefore, organismal homeostasis. Importantly, deregulation of mitochondrial homeostatic mechanisms, manifested as impaired mitochondrial biogenesis, metabolism and dynamics, has emerged as a hallmark of cellular senescence. On the other hand, impaired mitostasis has been suggested to induce cellular senescence. This review aims to provide an overview of homeostatic mechanisms operating within mitochondria and a comprehensive insight into the interplay between cellular senescence and mitochondrial dysfunction.

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