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Incidence of Cardiovascular Disease in Patients with Familial Hypercholesterolemia Phenotype: Analysis of 5 Years Follow-Up of Real-World Data from More than 1.5 Million Patients

In the statin era, the incidence of atherosclerotic cardiovascular diseases (ASCVD) in patients with familial hypercholesterolemia (FH) has not been updated. We aimed to determine the incidence of ASCVD in patients with FH-phenotype (FH-P) and to compare it with that of normal low-density lipoprotei...

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Autores principales: Masana, Luís, Zamora, Alberto, Plana, Núria, Comas-Cufí, Marc, Garcia-Gil, Maria, Martí-Lluch, Ruth, Ponjoan, Anna, Alves-Cabratosa, Lia, Elosua, Roberto, Marrugat, Jaume, Dégano, Irene R., Ramos, Rafel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678686/
https://www.ncbi.nlm.nih.gov/pubmed/31340450
http://dx.doi.org/10.3390/jcm8071080
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author Masana, Luís
Zamora, Alberto
Plana, Núria
Comas-Cufí, Marc
Garcia-Gil, Maria
Martí-Lluch, Ruth
Ponjoan, Anna
Alves-Cabratosa, Lia
Elosua, Roberto
Marrugat, Jaume
Dégano, Irene R.
Ramos, Rafel
author_facet Masana, Luís
Zamora, Alberto
Plana, Núria
Comas-Cufí, Marc
Garcia-Gil, Maria
Martí-Lluch, Ruth
Ponjoan, Anna
Alves-Cabratosa, Lia
Elosua, Roberto
Marrugat, Jaume
Dégano, Irene R.
Ramos, Rafel
author_sort Masana, Luís
collection PubMed
description In the statin era, the incidence of atherosclerotic cardiovascular diseases (ASCVD) in patients with familial hypercholesterolemia (FH) has not been updated. We aimed to determine the incidence of ASCVD in patients with FH-phenotype (FH-P) and to compare it with that of normal low-density lipoprotein cholesterol (LDL-C) patients. We performed a retrospective cohort study using the Database of the Catalan primary care system, including ≥18-year-old patients with an LDL-C measurement. From 1,589,264 patients available before 2009, 12,823 fulfilled FH-P criteria and 514,176 patients were normolipidemic (LDL-C < 115 mg/dL). In primary prevention, patients with FH-P had incidences of ASCVD and coronary heart disease (CHD) of 14.9/1000 and 5.8/1000 person-years, respectively, compared to 7.1/1000 and 2.1/1000 person-years in the normolipidemic group. FH-P showed hazard ratio (HR) of 7.1 and 16.7 for ASCVD and CHD, respectively, in patients younger than 35 years. In secondary prevention, patients with FH-P had incidences of ASCVD and CHD of 89.7/1000 and 34.5/1000 person-years, respectively, compared to 90.9/1000 and 28.2/1000 person-years in the normolipidemic group (HR in patients younger than 35 years: 2.4 and 6.0). In the statin era, FH-P remains associated with high cardiovascular risk, compared with the normolipidemic population. This excess of risk is markedly high in young individuals.
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spelling pubmed-66786862019-08-19 Incidence of Cardiovascular Disease in Patients with Familial Hypercholesterolemia Phenotype: Analysis of 5 Years Follow-Up of Real-World Data from More than 1.5 Million Patients Masana, Luís Zamora, Alberto Plana, Núria Comas-Cufí, Marc Garcia-Gil, Maria Martí-Lluch, Ruth Ponjoan, Anna Alves-Cabratosa, Lia Elosua, Roberto Marrugat, Jaume Dégano, Irene R. Ramos, Rafel J Clin Med Article In the statin era, the incidence of atherosclerotic cardiovascular diseases (ASCVD) in patients with familial hypercholesterolemia (FH) has not been updated. We aimed to determine the incidence of ASCVD in patients with FH-phenotype (FH-P) and to compare it with that of normal low-density lipoprotein cholesterol (LDL-C) patients. We performed a retrospective cohort study using the Database of the Catalan primary care system, including ≥18-year-old patients with an LDL-C measurement. From 1,589,264 patients available before 2009, 12,823 fulfilled FH-P criteria and 514,176 patients were normolipidemic (LDL-C < 115 mg/dL). In primary prevention, patients with FH-P had incidences of ASCVD and coronary heart disease (CHD) of 14.9/1000 and 5.8/1000 person-years, respectively, compared to 7.1/1000 and 2.1/1000 person-years in the normolipidemic group. FH-P showed hazard ratio (HR) of 7.1 and 16.7 for ASCVD and CHD, respectively, in patients younger than 35 years. In secondary prevention, patients with FH-P had incidences of ASCVD and CHD of 89.7/1000 and 34.5/1000 person-years, respectively, compared to 90.9/1000 and 28.2/1000 person-years in the normolipidemic group (HR in patients younger than 35 years: 2.4 and 6.0). In the statin era, FH-P remains associated with high cardiovascular risk, compared with the normolipidemic population. This excess of risk is markedly high in young individuals. MDPI 2019-07-23 /pmc/articles/PMC6678686/ /pubmed/31340450 http://dx.doi.org/10.3390/jcm8071080 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Masana, Luís
Zamora, Alberto
Plana, Núria
Comas-Cufí, Marc
Garcia-Gil, Maria
Martí-Lluch, Ruth
Ponjoan, Anna
Alves-Cabratosa, Lia
Elosua, Roberto
Marrugat, Jaume
Dégano, Irene R.
Ramos, Rafel
Incidence of Cardiovascular Disease in Patients with Familial Hypercholesterolemia Phenotype: Analysis of 5 Years Follow-Up of Real-World Data from More than 1.5 Million Patients
title Incidence of Cardiovascular Disease in Patients with Familial Hypercholesterolemia Phenotype: Analysis of 5 Years Follow-Up of Real-World Data from More than 1.5 Million Patients
title_full Incidence of Cardiovascular Disease in Patients with Familial Hypercholesterolemia Phenotype: Analysis of 5 Years Follow-Up of Real-World Data from More than 1.5 Million Patients
title_fullStr Incidence of Cardiovascular Disease in Patients with Familial Hypercholesterolemia Phenotype: Analysis of 5 Years Follow-Up of Real-World Data from More than 1.5 Million Patients
title_full_unstemmed Incidence of Cardiovascular Disease in Patients with Familial Hypercholesterolemia Phenotype: Analysis of 5 Years Follow-Up of Real-World Data from More than 1.5 Million Patients
title_short Incidence of Cardiovascular Disease in Patients with Familial Hypercholesterolemia Phenotype: Analysis of 5 Years Follow-Up of Real-World Data from More than 1.5 Million Patients
title_sort incidence of cardiovascular disease in patients with familial hypercholesterolemia phenotype: analysis of 5 years follow-up of real-world data from more than 1.5 million patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678686/
https://www.ncbi.nlm.nih.gov/pubmed/31340450
http://dx.doi.org/10.3390/jcm8071080
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