Cargando…

Fibroblast Growth Factor Receptor Functions in Glioblastoma

Glioblastoma is the most lethal brain cancer in adults, with no known cure. This cancer is characterized by a pronounced genetic heterogeneity, but aberrant activation of receptor tyrosine kinase signaling is among the most frequent molecular alterations in glioblastoma. Somatic mutations of fibrobl...

Descripción completa

Detalles Bibliográficos
Autores principales: Jimenez-Pascual, Ana, A. Siebzehnrubl, Florian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678715/
https://www.ncbi.nlm.nih.gov/pubmed/31337028
http://dx.doi.org/10.3390/cells8070715
_version_ 1783441167157821440
author Jimenez-Pascual, Ana
A. Siebzehnrubl, Florian
author_facet Jimenez-Pascual, Ana
A. Siebzehnrubl, Florian
author_sort Jimenez-Pascual, Ana
collection PubMed
description Glioblastoma is the most lethal brain cancer in adults, with no known cure. This cancer is characterized by a pronounced genetic heterogeneity, but aberrant activation of receptor tyrosine kinase signaling is among the most frequent molecular alterations in glioblastoma. Somatic mutations of fibroblast growth factor receptors (FGFRs) are rare in these cancers, but many studies have documented that signaling through FGFRs impacts glioblastoma progression and patient survival. Small-molecule inhibitors of FGFR tyrosine kinases are currently being trialed, underlining the therapeutic potential of blocking this signaling pathway. Nevertheless, a comprehensive overview of the state of the art of the literature on FGFRs in glioblastoma is lacking. Here, we review the evidence for the biological functions of FGFRs in glioblastoma, as well as pharmacological approaches to targeting these receptors.
format Online
Article
Text
id pubmed-6678715
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-66787152019-08-19 Fibroblast Growth Factor Receptor Functions in Glioblastoma Jimenez-Pascual, Ana A. Siebzehnrubl, Florian Cells Review Glioblastoma is the most lethal brain cancer in adults, with no known cure. This cancer is characterized by a pronounced genetic heterogeneity, but aberrant activation of receptor tyrosine kinase signaling is among the most frequent molecular alterations in glioblastoma. Somatic mutations of fibroblast growth factor receptors (FGFRs) are rare in these cancers, but many studies have documented that signaling through FGFRs impacts glioblastoma progression and patient survival. Small-molecule inhibitors of FGFR tyrosine kinases are currently being trialed, underlining the therapeutic potential of blocking this signaling pathway. Nevertheless, a comprehensive overview of the state of the art of the literature on FGFRs in glioblastoma is lacking. Here, we review the evidence for the biological functions of FGFRs in glioblastoma, as well as pharmacological approaches to targeting these receptors. MDPI 2019-07-13 /pmc/articles/PMC6678715/ /pubmed/31337028 http://dx.doi.org/10.3390/cells8070715 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jimenez-Pascual, Ana
A. Siebzehnrubl, Florian
Fibroblast Growth Factor Receptor Functions in Glioblastoma
title Fibroblast Growth Factor Receptor Functions in Glioblastoma
title_full Fibroblast Growth Factor Receptor Functions in Glioblastoma
title_fullStr Fibroblast Growth Factor Receptor Functions in Glioblastoma
title_full_unstemmed Fibroblast Growth Factor Receptor Functions in Glioblastoma
title_short Fibroblast Growth Factor Receptor Functions in Glioblastoma
title_sort fibroblast growth factor receptor functions in glioblastoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678715/
https://www.ncbi.nlm.nih.gov/pubmed/31337028
http://dx.doi.org/10.3390/cells8070715
work_keys_str_mv AT jimenezpascualana fibroblastgrowthfactorreceptorfunctionsinglioblastoma
AT asiebzehnrublflorian fibroblastgrowthfactorreceptorfunctionsinglioblastoma