Cargando…

The Association between Bisphenol A Exposure and Obesity in Children—A Systematic Review with Meta-Analysis

Bisphenol A (BPA) is an environmental chemical that has adverse effects on health, probably causing childhood obesity. However, this association remains controversial, and it is difficult to find evidence for direct causality between environmental exposure and disease using epidemiological studies....

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Ka Young, Lee, Eunil, Kim, Yanghee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678763/
https://www.ncbi.nlm.nih.gov/pubmed/31311074
http://dx.doi.org/10.3390/ijerph16142521
_version_ 1783441179025604608
author Kim, Ka Young
Lee, Eunil
Kim, Yanghee
author_facet Kim, Ka Young
Lee, Eunil
Kim, Yanghee
author_sort Kim, Ka Young
collection PubMed
description Bisphenol A (BPA) is an environmental chemical that has adverse effects on health, probably causing childhood obesity. However, this association remains controversial, and it is difficult to find evidence for direct causality between environmental exposure and disease using epidemiological studies. In this study, we sought to elucidate the possible causality between BPA exposure and childhood obesity by conducting two meta-analyses showing bidirectional associations, including exposure effect by obesity and obesity risk by exposure. Articles published up to September 2017 were searched in PubMed, Embase, and Cochrane Library. We evaluated observational studies that included measurements of urinary BPA concentration and BMI or body weight. Of 436 articles, a total of 13 studies were included in the meta-analysis. Two meta-analyses were performed to investigate the association between BPA exposure and childhood obesity. The results showed that the relatively high-exposed group had a significantly higher risk of childhood obesity than the relatively low-exposed group (odds ratio = 1.566, 95% confidence interval [CI]: 1.097 to 2.234, p = 0.014). However, the obese group showed no significant difference in the BPA concentration when compared to the normal group (standardized mean difference = 0.166, 95% CI: −0.121 to 0.453, p = 0.257). This study suggested possible causality between BPA exposure and childhood obesity using data from epidemiological studies and showed that BPA exposure itself increased the risk of obesity in children.
format Online
Article
Text
id pubmed-6678763
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-66787632019-08-19 The Association between Bisphenol A Exposure and Obesity in Children—A Systematic Review with Meta-Analysis Kim, Ka Young Lee, Eunil Kim, Yanghee Int J Environ Res Public Health Review Bisphenol A (BPA) is an environmental chemical that has adverse effects on health, probably causing childhood obesity. However, this association remains controversial, and it is difficult to find evidence for direct causality between environmental exposure and disease using epidemiological studies. In this study, we sought to elucidate the possible causality between BPA exposure and childhood obesity by conducting two meta-analyses showing bidirectional associations, including exposure effect by obesity and obesity risk by exposure. Articles published up to September 2017 were searched in PubMed, Embase, and Cochrane Library. We evaluated observational studies that included measurements of urinary BPA concentration and BMI or body weight. Of 436 articles, a total of 13 studies were included in the meta-analysis. Two meta-analyses were performed to investigate the association between BPA exposure and childhood obesity. The results showed that the relatively high-exposed group had a significantly higher risk of childhood obesity than the relatively low-exposed group (odds ratio = 1.566, 95% confidence interval [CI]: 1.097 to 2.234, p = 0.014). However, the obese group showed no significant difference in the BPA concentration when compared to the normal group (standardized mean difference = 0.166, 95% CI: −0.121 to 0.453, p = 0.257). This study suggested possible causality between BPA exposure and childhood obesity using data from epidemiological studies and showed that BPA exposure itself increased the risk of obesity in children. MDPI 2019-07-15 2019-07 /pmc/articles/PMC6678763/ /pubmed/31311074 http://dx.doi.org/10.3390/ijerph16142521 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kim, Ka Young
Lee, Eunil
Kim, Yanghee
The Association between Bisphenol A Exposure and Obesity in Children—A Systematic Review with Meta-Analysis
title The Association between Bisphenol A Exposure and Obesity in Children—A Systematic Review with Meta-Analysis
title_full The Association between Bisphenol A Exposure and Obesity in Children—A Systematic Review with Meta-Analysis
title_fullStr The Association between Bisphenol A Exposure and Obesity in Children—A Systematic Review with Meta-Analysis
title_full_unstemmed The Association between Bisphenol A Exposure and Obesity in Children—A Systematic Review with Meta-Analysis
title_short The Association between Bisphenol A Exposure and Obesity in Children—A Systematic Review with Meta-Analysis
title_sort association between bisphenol a exposure and obesity in children—a systematic review with meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678763/
https://www.ncbi.nlm.nih.gov/pubmed/31311074
http://dx.doi.org/10.3390/ijerph16142521
work_keys_str_mv AT kimkayoung theassociationbetweenbisphenolaexposureandobesityinchildrenasystematicreviewwithmetaanalysis
AT leeeunil theassociationbetweenbisphenolaexposureandobesityinchildrenasystematicreviewwithmetaanalysis
AT kimyanghee theassociationbetweenbisphenolaexposureandobesityinchildrenasystematicreviewwithmetaanalysis
AT kimkayoung associationbetweenbisphenolaexposureandobesityinchildrenasystematicreviewwithmetaanalysis
AT leeeunil associationbetweenbisphenolaexposureandobesityinchildrenasystematicreviewwithmetaanalysis
AT kimyanghee associationbetweenbisphenolaexposureandobesityinchildrenasystematicreviewwithmetaanalysis