Cargando…
The Association between Bisphenol A Exposure and Obesity in Children—A Systematic Review with Meta-Analysis
Bisphenol A (BPA) is an environmental chemical that has adverse effects on health, probably causing childhood obesity. However, this association remains controversial, and it is difficult to find evidence for direct causality between environmental exposure and disease using epidemiological studies....
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678763/ https://www.ncbi.nlm.nih.gov/pubmed/31311074 http://dx.doi.org/10.3390/ijerph16142521 |
_version_ | 1783441179025604608 |
---|---|
author | Kim, Ka Young Lee, Eunil Kim, Yanghee |
author_facet | Kim, Ka Young Lee, Eunil Kim, Yanghee |
author_sort | Kim, Ka Young |
collection | PubMed |
description | Bisphenol A (BPA) is an environmental chemical that has adverse effects on health, probably causing childhood obesity. However, this association remains controversial, and it is difficult to find evidence for direct causality between environmental exposure and disease using epidemiological studies. In this study, we sought to elucidate the possible causality between BPA exposure and childhood obesity by conducting two meta-analyses showing bidirectional associations, including exposure effect by obesity and obesity risk by exposure. Articles published up to September 2017 were searched in PubMed, Embase, and Cochrane Library. We evaluated observational studies that included measurements of urinary BPA concentration and BMI or body weight. Of 436 articles, a total of 13 studies were included in the meta-analysis. Two meta-analyses were performed to investigate the association between BPA exposure and childhood obesity. The results showed that the relatively high-exposed group had a significantly higher risk of childhood obesity than the relatively low-exposed group (odds ratio = 1.566, 95% confidence interval [CI]: 1.097 to 2.234, p = 0.014). However, the obese group showed no significant difference in the BPA concentration when compared to the normal group (standardized mean difference = 0.166, 95% CI: −0.121 to 0.453, p = 0.257). This study suggested possible causality between BPA exposure and childhood obesity using data from epidemiological studies and showed that BPA exposure itself increased the risk of obesity in children. |
format | Online Article Text |
id | pubmed-6678763 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-66787632019-08-19 The Association between Bisphenol A Exposure and Obesity in Children—A Systematic Review with Meta-Analysis Kim, Ka Young Lee, Eunil Kim, Yanghee Int J Environ Res Public Health Review Bisphenol A (BPA) is an environmental chemical that has adverse effects on health, probably causing childhood obesity. However, this association remains controversial, and it is difficult to find evidence for direct causality between environmental exposure and disease using epidemiological studies. In this study, we sought to elucidate the possible causality between BPA exposure and childhood obesity by conducting two meta-analyses showing bidirectional associations, including exposure effect by obesity and obesity risk by exposure. Articles published up to September 2017 were searched in PubMed, Embase, and Cochrane Library. We evaluated observational studies that included measurements of urinary BPA concentration and BMI or body weight. Of 436 articles, a total of 13 studies were included in the meta-analysis. Two meta-analyses were performed to investigate the association between BPA exposure and childhood obesity. The results showed that the relatively high-exposed group had a significantly higher risk of childhood obesity than the relatively low-exposed group (odds ratio = 1.566, 95% confidence interval [CI]: 1.097 to 2.234, p = 0.014). However, the obese group showed no significant difference in the BPA concentration when compared to the normal group (standardized mean difference = 0.166, 95% CI: −0.121 to 0.453, p = 0.257). This study suggested possible causality between BPA exposure and childhood obesity using data from epidemiological studies and showed that BPA exposure itself increased the risk of obesity in children. MDPI 2019-07-15 2019-07 /pmc/articles/PMC6678763/ /pubmed/31311074 http://dx.doi.org/10.3390/ijerph16142521 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kim, Ka Young Lee, Eunil Kim, Yanghee The Association between Bisphenol A Exposure and Obesity in Children—A Systematic Review with Meta-Analysis |
title | The Association between Bisphenol A Exposure and Obesity in Children—A Systematic Review with Meta-Analysis |
title_full | The Association between Bisphenol A Exposure and Obesity in Children—A Systematic Review with Meta-Analysis |
title_fullStr | The Association between Bisphenol A Exposure and Obesity in Children—A Systematic Review with Meta-Analysis |
title_full_unstemmed | The Association between Bisphenol A Exposure and Obesity in Children—A Systematic Review with Meta-Analysis |
title_short | The Association between Bisphenol A Exposure and Obesity in Children—A Systematic Review with Meta-Analysis |
title_sort | association between bisphenol a exposure and obesity in children—a systematic review with meta-analysis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678763/ https://www.ncbi.nlm.nih.gov/pubmed/31311074 http://dx.doi.org/10.3390/ijerph16142521 |
work_keys_str_mv | AT kimkayoung theassociationbetweenbisphenolaexposureandobesityinchildrenasystematicreviewwithmetaanalysis AT leeeunil theassociationbetweenbisphenolaexposureandobesityinchildrenasystematicreviewwithmetaanalysis AT kimyanghee theassociationbetweenbisphenolaexposureandobesityinchildrenasystematicreviewwithmetaanalysis AT kimkayoung associationbetweenbisphenolaexposureandobesityinchildrenasystematicreviewwithmetaanalysis AT leeeunil associationbetweenbisphenolaexposureandobesityinchildrenasystematicreviewwithmetaanalysis AT kimyanghee associationbetweenbisphenolaexposureandobesityinchildrenasystematicreviewwithmetaanalysis |