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Body Weight Fluctuation as a Risk Factor for Type 2 Diabetes: Results from a Nationwide Cohort Study

We aimed to investigate how body weight fluctuation affects the risk of developing type 2 diabetes by conducting a nationwide cohort study. A total of 3,855,884 participants from the National Health Insurance System health check-up data from 2012 were included in this study, and follow-up continued...

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Autores principales: Park, Kye-Yeung, Hwang, Hwan-Sik, Cho, Kyung-Hwan, Han, Kyungdo, Nam, Ga Eun, Kim, Yang Hyun, Kwon, Yeongkeun, Park, Yong-Gyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678837/
https://www.ncbi.nlm.nih.gov/pubmed/31261984
http://dx.doi.org/10.3390/jcm8070950
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author Park, Kye-Yeung
Hwang, Hwan-Sik
Cho, Kyung-Hwan
Han, Kyungdo
Nam, Ga Eun
Kim, Yang Hyun
Kwon, Yeongkeun
Park, Yong-Gyu
author_facet Park, Kye-Yeung
Hwang, Hwan-Sik
Cho, Kyung-Hwan
Han, Kyungdo
Nam, Ga Eun
Kim, Yang Hyun
Kwon, Yeongkeun
Park, Yong-Gyu
author_sort Park, Kye-Yeung
collection PubMed
description We aimed to investigate how body weight fluctuation affects the risk of developing type 2 diabetes by conducting a nationwide cohort study. A total of 3,855,884 participants from the National Health Insurance System health check-up data from 2012 were included in this study, and follow-up continued until 2016. Body weight was measured at least thrice between 2009 and 2012. Body weight variability (BWV) was estimated using average successive variability (ASV) indices. Cox proportional hazards regression models were used to evaluate the association of BWV with the risk of type 2 diabetes using hazard ratios (HRs) and 95% confidence intervals (CIs). Body weight fluctuation was associated with a higher risk of incident diabetes after adjustment for confounders (HR 1.10, 95% CI 1.07, 1.12 in the highest BWV quartile compared to the lowest). Regardless of the weight change status, the highest ASV quartile of BWV increased the risk for diabetes. Even subjects with a normal glucose tolerance status and those aged under 65 years had a higher risk of diabetes if their body weight highly fluctuated during the follow-up years. Our results suggest that body weight variability is an independent risk factor for diabetes. It is important to pay attention to frequent body weight fluctuations.
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spelling pubmed-66788372019-08-19 Body Weight Fluctuation as a Risk Factor for Type 2 Diabetes: Results from a Nationwide Cohort Study Park, Kye-Yeung Hwang, Hwan-Sik Cho, Kyung-Hwan Han, Kyungdo Nam, Ga Eun Kim, Yang Hyun Kwon, Yeongkeun Park, Yong-Gyu J Clin Med Article We aimed to investigate how body weight fluctuation affects the risk of developing type 2 diabetes by conducting a nationwide cohort study. A total of 3,855,884 participants from the National Health Insurance System health check-up data from 2012 were included in this study, and follow-up continued until 2016. Body weight was measured at least thrice between 2009 and 2012. Body weight variability (BWV) was estimated using average successive variability (ASV) indices. Cox proportional hazards regression models were used to evaluate the association of BWV with the risk of type 2 diabetes using hazard ratios (HRs) and 95% confidence intervals (CIs). Body weight fluctuation was associated with a higher risk of incident diabetes after adjustment for confounders (HR 1.10, 95% CI 1.07, 1.12 in the highest BWV quartile compared to the lowest). Regardless of the weight change status, the highest ASV quartile of BWV increased the risk for diabetes. Even subjects with a normal glucose tolerance status and those aged under 65 years had a higher risk of diabetes if their body weight highly fluctuated during the follow-up years. Our results suggest that body weight variability is an independent risk factor for diabetes. It is important to pay attention to frequent body weight fluctuations. MDPI 2019-06-30 /pmc/articles/PMC6678837/ /pubmed/31261984 http://dx.doi.org/10.3390/jcm8070950 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Park, Kye-Yeung
Hwang, Hwan-Sik
Cho, Kyung-Hwan
Han, Kyungdo
Nam, Ga Eun
Kim, Yang Hyun
Kwon, Yeongkeun
Park, Yong-Gyu
Body Weight Fluctuation as a Risk Factor for Type 2 Diabetes: Results from a Nationwide Cohort Study
title Body Weight Fluctuation as a Risk Factor for Type 2 Diabetes: Results from a Nationwide Cohort Study
title_full Body Weight Fluctuation as a Risk Factor for Type 2 Diabetes: Results from a Nationwide Cohort Study
title_fullStr Body Weight Fluctuation as a Risk Factor for Type 2 Diabetes: Results from a Nationwide Cohort Study
title_full_unstemmed Body Weight Fluctuation as a Risk Factor for Type 2 Diabetes: Results from a Nationwide Cohort Study
title_short Body Weight Fluctuation as a Risk Factor for Type 2 Diabetes: Results from a Nationwide Cohort Study
title_sort body weight fluctuation as a risk factor for type 2 diabetes: results from a nationwide cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678837/
https://www.ncbi.nlm.nih.gov/pubmed/31261984
http://dx.doi.org/10.3390/jcm8070950
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