Cargando…

3D-Analysis of Mouth, Nose and Eye Parameters in Children with Fetal Alcohol Syndrome (FAS)

Background: Fetal alcohol spectrum disorder (FASD) is a developmental disorder with severe negative lifetime consequences for the affected person. Numerous diagnostic methods for facial assessment in FAS exist, but most of them are based on subjective evaluations. Our aim was therefore to find objec...

Descripción completa

Detalles Bibliográficos
Autores principales: Blanck-Lubarsch, Moritz, Dirksen, Dieter, Feldmann, Reinhold, Sauerland, Cristina, Hohoff, Ariane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678862/
https://www.ncbi.nlm.nih.gov/pubmed/31315192
http://dx.doi.org/10.3390/ijerph16142535
_version_ 1783441202893291520
author Blanck-Lubarsch, Moritz
Dirksen, Dieter
Feldmann, Reinhold
Sauerland, Cristina
Hohoff, Ariane
author_facet Blanck-Lubarsch, Moritz
Dirksen, Dieter
Feldmann, Reinhold
Sauerland, Cristina
Hohoff, Ariane
author_sort Blanck-Lubarsch, Moritz
collection PubMed
description Background: Fetal alcohol spectrum disorder (FASD) is a developmental disorder with severe negative lifetime consequences for the affected person. Numerous diagnostic methods for facial assessment in FAS exist, but most of them are based on subjective evaluations. Our aim was therefore to find objective methods for the verification of FAS(D). Methods: 58 children (28 FAS; 30 controls) were examined prospectively. 3D facial scans were performed for each child and facial parameters at the mouth, nose and eye regions were measured and compared between the groups. Results: Significant differences could be found for the distance between right and left sulcus nasi at the transition point to the philtrum (p < 0.001), for the inner canthal distance (p = 0.001) as well as for the right and left palpebral fissure length (p < 0.001). No significant difference between the FAS and control children could be found for the measurements of mouth breadth (p = 0.267) and breadth between the left and right alares nasi (p = 0.260). Conclusions: Measurements of mouth breadth and nose breadth for the alares nasi are not suitable for FAS diagnosis. In contrast, digital contactless measurements of the distance between the right and left sulcus nasi at the transition point to the philtrum, as well as the inner canthal distance and palpebral fissure length of the left and right eyes, showed significant differences when comparing children with FAS to healthy controls. These measurements could thus be additional objective means for the verification of FAS.
format Online
Article
Text
id pubmed-6678862
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-66788622019-08-19 3D-Analysis of Mouth, Nose and Eye Parameters in Children with Fetal Alcohol Syndrome (FAS) Blanck-Lubarsch, Moritz Dirksen, Dieter Feldmann, Reinhold Sauerland, Cristina Hohoff, Ariane Int J Environ Res Public Health Article Background: Fetal alcohol spectrum disorder (FASD) is a developmental disorder with severe negative lifetime consequences for the affected person. Numerous diagnostic methods for facial assessment in FAS exist, but most of them are based on subjective evaluations. Our aim was therefore to find objective methods for the verification of FAS(D). Methods: 58 children (28 FAS; 30 controls) were examined prospectively. 3D facial scans were performed for each child and facial parameters at the mouth, nose and eye regions were measured and compared between the groups. Results: Significant differences could be found for the distance between right and left sulcus nasi at the transition point to the philtrum (p < 0.001), for the inner canthal distance (p = 0.001) as well as for the right and left palpebral fissure length (p < 0.001). No significant difference between the FAS and control children could be found for the measurements of mouth breadth (p = 0.267) and breadth between the left and right alares nasi (p = 0.260). Conclusions: Measurements of mouth breadth and nose breadth for the alares nasi are not suitable for FAS diagnosis. In contrast, digital contactless measurements of the distance between the right and left sulcus nasi at the transition point to the philtrum, as well as the inner canthal distance and palpebral fissure length of the left and right eyes, showed significant differences when comparing children with FAS to healthy controls. These measurements could thus be additional objective means for the verification of FAS. MDPI 2019-07-16 2019-07 /pmc/articles/PMC6678862/ /pubmed/31315192 http://dx.doi.org/10.3390/ijerph16142535 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Blanck-Lubarsch, Moritz
Dirksen, Dieter
Feldmann, Reinhold
Sauerland, Cristina
Hohoff, Ariane
3D-Analysis of Mouth, Nose and Eye Parameters in Children with Fetal Alcohol Syndrome (FAS)
title 3D-Analysis of Mouth, Nose and Eye Parameters in Children with Fetal Alcohol Syndrome (FAS)
title_full 3D-Analysis of Mouth, Nose and Eye Parameters in Children with Fetal Alcohol Syndrome (FAS)
title_fullStr 3D-Analysis of Mouth, Nose and Eye Parameters in Children with Fetal Alcohol Syndrome (FAS)
title_full_unstemmed 3D-Analysis of Mouth, Nose and Eye Parameters in Children with Fetal Alcohol Syndrome (FAS)
title_short 3D-Analysis of Mouth, Nose and Eye Parameters in Children with Fetal Alcohol Syndrome (FAS)
title_sort 3d-analysis of mouth, nose and eye parameters in children with fetal alcohol syndrome (fas)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678862/
https://www.ncbi.nlm.nih.gov/pubmed/31315192
http://dx.doi.org/10.3390/ijerph16142535
work_keys_str_mv AT blancklubarschmoritz 3danalysisofmouthnoseandeyeparametersinchildrenwithfetalalcoholsyndromefas
AT dirksendieter 3danalysisofmouthnoseandeyeparametersinchildrenwithfetalalcoholsyndromefas
AT feldmannreinhold 3danalysisofmouthnoseandeyeparametersinchildrenwithfetalalcoholsyndromefas
AT sauerlandcristina 3danalysisofmouthnoseandeyeparametersinchildrenwithfetalalcoholsyndromefas
AT hohoffariane 3danalysisofmouthnoseandeyeparametersinchildrenwithfetalalcoholsyndromefas