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The Effectiveness of 0.6% Povidone Iodine Eye Drops in Reducing the Conjunctival Bacterial Load and Needle Contamination in Patients Undergoing Anti-VEGF Intravitreal Injection: A Prospective, Randomized Study
The study purpose was to assess the efficacy of a preservative-free 0.6% povidone iodine eye drops as perioperative prophylactic treatment for reducing conjunctival bacterial load and the rate of needle contamination in patients undergoing intravitreal anti-vascular endothelial growth factor injecti...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678890/ https://www.ncbi.nlm.nih.gov/pubmed/31337003 http://dx.doi.org/10.3390/jcm8071031 |
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author | Reibaldi, Michele Avitabile, Teresio Bandello, Francesco Longo, Antonio Bonfiglio, Vincenza Russo, Andrea Castellino, Niccolò Rejdak, Robert Nowomiejska, Katarzyna Toro, Mario Furino, Claudio Cillino, Salvatore Fiore, Tito Cagini, Carlo Grassi, Patrizia Musumeci, Rosario Cocuzza, Clementina Elvezia Martinelli, Marianna Fallico, Matteo |
author_facet | Reibaldi, Michele Avitabile, Teresio Bandello, Francesco Longo, Antonio Bonfiglio, Vincenza Russo, Andrea Castellino, Niccolò Rejdak, Robert Nowomiejska, Katarzyna Toro, Mario Furino, Claudio Cillino, Salvatore Fiore, Tito Cagini, Carlo Grassi, Patrizia Musumeci, Rosario Cocuzza, Clementina Elvezia Martinelli, Marianna Fallico, Matteo |
author_sort | Reibaldi, Michele |
collection | PubMed |
description | The study purpose was to assess the efficacy of a preservative-free 0.6% povidone iodine eye drops as perioperative prophylactic treatment for reducing conjunctival bacterial load and the rate of needle contamination in patients undergoing intravitreal anti-vascular endothelial growth factor injection. Enrolled patients were randomized to either the study group (0.6% povidone iodine, three day-prophylactic treatment before the injection) or to the control group (placebo, three day-prophylactic treatment). Conjunctival swabs were obtained before and after the prophylactic treatment in both groups. Intravitreal injections were performed in a sterile fashion. The injection needle and a control needle were collected for microbiological culture. Data from 254 and 253 eyes in the study group and control group, respectively, were analyzed. Bacterial growth from conjunctival swab cultures was significantly lower after 0.6% povidone iodine prophylaxis compared to baseline and to placebo prophylaxis (p < 0.001), showing an 82% eradication rate in the study group. No injection needle showed bacterial contamination in the study group, whereas six needles were culture-positive in the control group (p = 0.015). No serious ocular and non-ocular adverse events were recorded. The 0.6% povidone iodine solution proved an effective treatment in reducing conjunctival bacterial load and risk of needle contamination. |
format | Online Article Text |
id | pubmed-6678890 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-66788902019-08-19 The Effectiveness of 0.6% Povidone Iodine Eye Drops in Reducing the Conjunctival Bacterial Load and Needle Contamination in Patients Undergoing Anti-VEGF Intravitreal Injection: A Prospective, Randomized Study Reibaldi, Michele Avitabile, Teresio Bandello, Francesco Longo, Antonio Bonfiglio, Vincenza Russo, Andrea Castellino, Niccolò Rejdak, Robert Nowomiejska, Katarzyna Toro, Mario Furino, Claudio Cillino, Salvatore Fiore, Tito Cagini, Carlo Grassi, Patrizia Musumeci, Rosario Cocuzza, Clementina Elvezia Martinelli, Marianna Fallico, Matteo J Clin Med Article The study purpose was to assess the efficacy of a preservative-free 0.6% povidone iodine eye drops as perioperative prophylactic treatment for reducing conjunctival bacterial load and the rate of needle contamination in patients undergoing intravitreal anti-vascular endothelial growth factor injection. Enrolled patients were randomized to either the study group (0.6% povidone iodine, three day-prophylactic treatment before the injection) or to the control group (placebo, three day-prophylactic treatment). Conjunctival swabs were obtained before and after the prophylactic treatment in both groups. Intravitreal injections were performed in a sterile fashion. The injection needle and a control needle were collected for microbiological culture. Data from 254 and 253 eyes in the study group and control group, respectively, were analyzed. Bacterial growth from conjunctival swab cultures was significantly lower after 0.6% povidone iodine prophylaxis compared to baseline and to placebo prophylaxis (p < 0.001), showing an 82% eradication rate in the study group. No injection needle showed bacterial contamination in the study group, whereas six needles were culture-positive in the control group (p = 0.015). No serious ocular and non-ocular adverse events were recorded. The 0.6% povidone iodine solution proved an effective treatment in reducing conjunctival bacterial load and risk of needle contamination. MDPI 2019-07-13 /pmc/articles/PMC6678890/ /pubmed/31337003 http://dx.doi.org/10.3390/jcm8071031 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Reibaldi, Michele Avitabile, Teresio Bandello, Francesco Longo, Antonio Bonfiglio, Vincenza Russo, Andrea Castellino, Niccolò Rejdak, Robert Nowomiejska, Katarzyna Toro, Mario Furino, Claudio Cillino, Salvatore Fiore, Tito Cagini, Carlo Grassi, Patrizia Musumeci, Rosario Cocuzza, Clementina Elvezia Martinelli, Marianna Fallico, Matteo The Effectiveness of 0.6% Povidone Iodine Eye Drops in Reducing the Conjunctival Bacterial Load and Needle Contamination in Patients Undergoing Anti-VEGF Intravitreal Injection: A Prospective, Randomized Study |
title | The Effectiveness of 0.6% Povidone Iodine Eye Drops in Reducing the Conjunctival Bacterial Load and Needle Contamination in Patients Undergoing Anti-VEGF Intravitreal Injection: A Prospective, Randomized Study |
title_full | The Effectiveness of 0.6% Povidone Iodine Eye Drops in Reducing the Conjunctival Bacterial Load and Needle Contamination in Patients Undergoing Anti-VEGF Intravitreal Injection: A Prospective, Randomized Study |
title_fullStr | The Effectiveness of 0.6% Povidone Iodine Eye Drops in Reducing the Conjunctival Bacterial Load and Needle Contamination in Patients Undergoing Anti-VEGF Intravitreal Injection: A Prospective, Randomized Study |
title_full_unstemmed | The Effectiveness of 0.6% Povidone Iodine Eye Drops in Reducing the Conjunctival Bacterial Load and Needle Contamination in Patients Undergoing Anti-VEGF Intravitreal Injection: A Prospective, Randomized Study |
title_short | The Effectiveness of 0.6% Povidone Iodine Eye Drops in Reducing the Conjunctival Bacterial Load and Needle Contamination in Patients Undergoing Anti-VEGF Intravitreal Injection: A Prospective, Randomized Study |
title_sort | effectiveness of 0.6% povidone iodine eye drops in reducing the conjunctival bacterial load and needle contamination in patients undergoing anti-vegf intravitreal injection: a prospective, randomized study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678890/ https://www.ncbi.nlm.nih.gov/pubmed/31337003 http://dx.doi.org/10.3390/jcm8071031 |
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