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B Cells as an Immune-Regulatory Signature in Ovarian Cancer
Increasing evidence suggests that the immune system plays a dynamic role in the progression of ovarian cancer, the deadliest gynecological malignancy worldwide. Accumulation of tumor-infiltrating lymphocytes has been associated with increased survival in ovarian cancer patients, and diverse interact...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678944/ https://www.ncbi.nlm.nih.gov/pubmed/31248034 http://dx.doi.org/10.3390/cancers11070894 |
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author | Gupta, Prachi Chen, Changliang Chaluvally-Raghavan, Pradeep Pradeep, Sunila |
author_facet | Gupta, Prachi Chen, Changliang Chaluvally-Raghavan, Pradeep Pradeep, Sunila |
author_sort | Gupta, Prachi |
collection | PubMed |
description | Increasing evidence suggests that the immune system plays a dynamic role in the progression of ovarian cancer, the deadliest gynecological malignancy worldwide. Accumulation of tumor-infiltrating lymphocytes has been associated with increased survival in ovarian cancer patients, and diverse interactions among immune cells in the tumor microenvironment determine tumor progression. While the regulatory functions of T cells among tumor-infiltrating lymphocytes are well defined and also involve therapeutic interventions, the role of B cells in ovarian cancer progression is still limited to their impact on survival. Recent studies have identified both pro- and anti-tumor responses of B cells in solid tumors, as different subsets of B cells play diverse roles in progression. Thus, in-depth characterization of B cell subtypes in each disease stage is crucial for understanding the importance and therapeutic potential of these cells in ovarian cancer. In this review, we summarize current knowledge about B cells in ovarian cancer and discuss emerging therapeutic interventions that could harness B cells to combat this deadly disease. |
format | Online Article Text |
id | pubmed-6678944 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-66789442019-08-19 B Cells as an Immune-Regulatory Signature in Ovarian Cancer Gupta, Prachi Chen, Changliang Chaluvally-Raghavan, Pradeep Pradeep, Sunila Cancers (Basel) Review Increasing evidence suggests that the immune system plays a dynamic role in the progression of ovarian cancer, the deadliest gynecological malignancy worldwide. Accumulation of tumor-infiltrating lymphocytes has been associated with increased survival in ovarian cancer patients, and diverse interactions among immune cells in the tumor microenvironment determine tumor progression. While the regulatory functions of T cells among tumor-infiltrating lymphocytes are well defined and also involve therapeutic interventions, the role of B cells in ovarian cancer progression is still limited to their impact on survival. Recent studies have identified both pro- and anti-tumor responses of B cells in solid tumors, as different subsets of B cells play diverse roles in progression. Thus, in-depth characterization of B cell subtypes in each disease stage is crucial for understanding the importance and therapeutic potential of these cells in ovarian cancer. In this review, we summarize current knowledge about B cells in ovarian cancer and discuss emerging therapeutic interventions that could harness B cells to combat this deadly disease. MDPI 2019-06-26 /pmc/articles/PMC6678944/ /pubmed/31248034 http://dx.doi.org/10.3390/cancers11070894 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Gupta, Prachi Chen, Changliang Chaluvally-Raghavan, Pradeep Pradeep, Sunila B Cells as an Immune-Regulatory Signature in Ovarian Cancer |
title | B Cells as an Immune-Regulatory Signature in Ovarian Cancer |
title_full | B Cells as an Immune-Regulatory Signature in Ovarian Cancer |
title_fullStr | B Cells as an Immune-Regulatory Signature in Ovarian Cancer |
title_full_unstemmed | B Cells as an Immune-Regulatory Signature in Ovarian Cancer |
title_short | B Cells as an Immune-Regulatory Signature in Ovarian Cancer |
title_sort | b cells as an immune-regulatory signature in ovarian cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678944/ https://www.ncbi.nlm.nih.gov/pubmed/31248034 http://dx.doi.org/10.3390/cancers11070894 |
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