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Association of lncRNA H19 Gene Polymorphisms with the Occurrence of Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, whose diversified occurrence worldwide indicates a connection between genetic variations among individuals and the predisposition to such neoplasms. Mounting evidence has demonstrated that long non-coding RNA (lncRNA) H1...

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Autores principales: Wu, Edie-Rosmin, Chou, Ying-Erh, Liu, Yu-Fan, Hsueh, Kuan-Chun, Lee, Hsiang-Lin, Yang, Shun-Fa, Su, Shih-Chi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678962/
https://www.ncbi.nlm.nih.gov/pubmed/31277475
http://dx.doi.org/10.3390/genes10070506
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author Wu, Edie-Rosmin
Chou, Ying-Erh
Liu, Yu-Fan
Hsueh, Kuan-Chun
Lee, Hsiang-Lin
Yang, Shun-Fa
Su, Shih-Chi
author_facet Wu, Edie-Rosmin
Chou, Ying-Erh
Liu, Yu-Fan
Hsueh, Kuan-Chun
Lee, Hsiang-Lin
Yang, Shun-Fa
Su, Shih-Chi
author_sort Wu, Edie-Rosmin
collection PubMed
description Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, whose diversified occurrence worldwide indicates a connection between genetic variations among individuals and the predisposition to such neoplasms. Mounting evidence has demonstrated that long non-coding RNA (lncRNA) H19 can have both promotive and inhibitory effects on cancer development, revealing a dual role in tumorigenesis. In this study, the link of H19 gene polymorphisms to hepatocarcinogenesis was assessed between 359 HCC patients and 1190 cancer-free subjects. We found that heterozygotes for the minor allele of H19 rs2839698 (T) and rs3741219 (G) were more inclined to develop HCC (OR, 1.291; 95% CI, 1.003–1.661; p = 0.047, and OR, 1.361; 95% CI, 1.054–1.758; p = 0.018, respectively), whereas homozygotes for the polymorphic allele of rs2107425 (TT) were correlated with a decreased risk of HCC (OR, 0.606; 95% CI, 0.410–0.895; p = 0.012). Moreover, patients who bear at least one variant allele (heterozygote or homozygote) of rs3024270 were less prone to develop late-stage tumors (for stage III/IV; OR, 0.566; 95% CI, 0.342–0.937; p = 0.027). In addition, carriers of a particular haplotype of three H19 SNPs tested were more susceptible to HCC. In conclusion, our results indicate an association between H19 gene polymorphisms and the incidence and progression of liver cancer.
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spelling pubmed-66789622019-08-19 Association of lncRNA H19 Gene Polymorphisms with the Occurrence of Hepatocellular Carcinoma Wu, Edie-Rosmin Chou, Ying-Erh Liu, Yu-Fan Hsueh, Kuan-Chun Lee, Hsiang-Lin Yang, Shun-Fa Su, Shih-Chi Genes (Basel) Article Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, whose diversified occurrence worldwide indicates a connection between genetic variations among individuals and the predisposition to such neoplasms. Mounting evidence has demonstrated that long non-coding RNA (lncRNA) H19 can have both promotive and inhibitory effects on cancer development, revealing a dual role in tumorigenesis. In this study, the link of H19 gene polymorphisms to hepatocarcinogenesis was assessed between 359 HCC patients and 1190 cancer-free subjects. We found that heterozygotes for the minor allele of H19 rs2839698 (T) and rs3741219 (G) were more inclined to develop HCC (OR, 1.291; 95% CI, 1.003–1.661; p = 0.047, and OR, 1.361; 95% CI, 1.054–1.758; p = 0.018, respectively), whereas homozygotes for the polymorphic allele of rs2107425 (TT) were correlated with a decreased risk of HCC (OR, 0.606; 95% CI, 0.410–0.895; p = 0.012). Moreover, patients who bear at least one variant allele (heterozygote or homozygote) of rs3024270 were less prone to develop late-stage tumors (for stage III/IV; OR, 0.566; 95% CI, 0.342–0.937; p = 0.027). In addition, carriers of a particular haplotype of three H19 SNPs tested were more susceptible to HCC. In conclusion, our results indicate an association between H19 gene polymorphisms and the incidence and progression of liver cancer. MDPI 2019-07-04 /pmc/articles/PMC6678962/ /pubmed/31277475 http://dx.doi.org/10.3390/genes10070506 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wu, Edie-Rosmin
Chou, Ying-Erh
Liu, Yu-Fan
Hsueh, Kuan-Chun
Lee, Hsiang-Lin
Yang, Shun-Fa
Su, Shih-Chi
Association of lncRNA H19 Gene Polymorphisms with the Occurrence of Hepatocellular Carcinoma
title Association of lncRNA H19 Gene Polymorphisms with the Occurrence of Hepatocellular Carcinoma
title_full Association of lncRNA H19 Gene Polymorphisms with the Occurrence of Hepatocellular Carcinoma
title_fullStr Association of lncRNA H19 Gene Polymorphisms with the Occurrence of Hepatocellular Carcinoma
title_full_unstemmed Association of lncRNA H19 Gene Polymorphisms with the Occurrence of Hepatocellular Carcinoma
title_short Association of lncRNA H19 Gene Polymorphisms with the Occurrence of Hepatocellular Carcinoma
title_sort association of lncrna h19 gene polymorphisms with the occurrence of hepatocellular carcinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678962/
https://www.ncbi.nlm.nih.gov/pubmed/31277475
http://dx.doi.org/10.3390/genes10070506
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