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Emerging Roles of RAD52 in Genome Maintenance
The maintenance of genome integrity is critical for cell survival. Homologous recombination (HR) is considered the major error-free repair pathway in combatting endogenously generated double-stranded lesions in DNA. Nevertheless, a number of alternative repair pathways have been described as protect...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679097/ https://www.ncbi.nlm.nih.gov/pubmed/31340507 http://dx.doi.org/10.3390/cancers11071038 |
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author | Jalan, Manisha Olsen, Kyrie S. Powell, Simon N. |
author_facet | Jalan, Manisha Olsen, Kyrie S. Powell, Simon N. |
author_sort | Jalan, Manisha |
collection | PubMed |
description | The maintenance of genome integrity is critical for cell survival. Homologous recombination (HR) is considered the major error-free repair pathway in combatting endogenously generated double-stranded lesions in DNA. Nevertheless, a number of alternative repair pathways have been described as protectors of genome stability, especially in HR-deficient cells. One of the factors that appears to have a role in many of these pathways is human RAD52, a DNA repair protein that was previously considered to be dispensable due to a lack of an observable phenotype in knock-out mice. In later studies, RAD52 deficiency has been shown to be synthetically lethal with defects in BRCA genes, making RAD52 an attractive therapeutic target, particularly in the context of BRCA-deficient tumors. |
format | Online Article Text |
id | pubmed-6679097 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-66790972019-08-19 Emerging Roles of RAD52 in Genome Maintenance Jalan, Manisha Olsen, Kyrie S. Powell, Simon N. Cancers (Basel) Review The maintenance of genome integrity is critical for cell survival. Homologous recombination (HR) is considered the major error-free repair pathway in combatting endogenously generated double-stranded lesions in DNA. Nevertheless, a number of alternative repair pathways have been described as protectors of genome stability, especially in HR-deficient cells. One of the factors that appears to have a role in many of these pathways is human RAD52, a DNA repair protein that was previously considered to be dispensable due to a lack of an observable phenotype in knock-out mice. In later studies, RAD52 deficiency has been shown to be synthetically lethal with defects in BRCA genes, making RAD52 an attractive therapeutic target, particularly in the context of BRCA-deficient tumors. MDPI 2019-07-23 /pmc/articles/PMC6679097/ /pubmed/31340507 http://dx.doi.org/10.3390/cancers11071038 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Jalan, Manisha Olsen, Kyrie S. Powell, Simon N. Emerging Roles of RAD52 in Genome Maintenance |
title | Emerging Roles of RAD52 in Genome Maintenance |
title_full | Emerging Roles of RAD52 in Genome Maintenance |
title_fullStr | Emerging Roles of RAD52 in Genome Maintenance |
title_full_unstemmed | Emerging Roles of RAD52 in Genome Maintenance |
title_short | Emerging Roles of RAD52 in Genome Maintenance |
title_sort | emerging roles of rad52 in genome maintenance |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679097/ https://www.ncbi.nlm.nih.gov/pubmed/31340507 http://dx.doi.org/10.3390/cancers11071038 |
work_keys_str_mv | AT jalanmanisha emergingrolesofrad52ingenomemaintenance AT olsenkyries emergingrolesofrad52ingenomemaintenance AT powellsimonn emergingrolesofrad52ingenomemaintenance |