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Autoantibodies to Apolipoprotein A-1 as Independent Predictors of Cardiovascular Mortality in Renal Transplant Recipients

Renal transplant recipients (RTRs) are known to have a high cardio-vascular disease (CVD) burden only partly explained by traditional CVD risk factors. The aim of this paper was therefore to determine: i) the prognostic value of autoantibodies against apoA-1 (anti-apoA-1 IgG) for incidence of CVD mo...

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Autores principales: Anderson, Josephine L.C., Pagano, Sabrina, Virzi, Julien, Dullaart, Robin P.F., Annema, Wijtske, Kuipers, Folkert, Bakker, Stephan J.L., Vuilleumier, Nicolas, Tietge, Uwe J.F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679113/
https://www.ncbi.nlm.nih.gov/pubmed/31261925
http://dx.doi.org/10.3390/jcm8070948
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author Anderson, Josephine L.C.
Pagano, Sabrina
Virzi, Julien
Dullaart, Robin P.F.
Annema, Wijtske
Kuipers, Folkert
Bakker, Stephan J.L.
Vuilleumier, Nicolas
Tietge, Uwe J.F.
author_facet Anderson, Josephine L.C.
Pagano, Sabrina
Virzi, Julien
Dullaart, Robin P.F.
Annema, Wijtske
Kuipers, Folkert
Bakker, Stephan J.L.
Vuilleumier, Nicolas
Tietge, Uwe J.F.
author_sort Anderson, Josephine L.C.
collection PubMed
description Renal transplant recipients (RTRs) are known to have a high cardio-vascular disease (CVD) burden only partly explained by traditional CVD risk factors. The aim of this paper was therefore to determine: i) the prognostic value of autoantibodies against apoA-1 (anti-apoA-1 IgG) for incidence of CVD mortality, all-cause mortality and graft failure in RTR. Four hundred and sixty two (462) prospectively included RTRs were followed for 7.0 years. Baseline anti-apoA-1 IgG were determined and associations with incidence of CVD mortality (n = 48), all-cause mortality (n = 92) and graft failure (n = 39) were tested. Kaplan–Meier analyses demonstrated significant associations between tertiles of anti-apoA-1 IgG and CVD mortality (log rank test: p = 0.048). Adjusted Cox regression analysis showed a 54% increase in risk for CVD mortality for each anti-apoA-1 IgG levels standard deviation increase (hazard ratio [HR]: 1.54, 95% Confidence Interval [95%CI]: 1.14–2.05, p = 0.005), and a 33% increase for all-cause mortality (HR: 1.33; 95%CI: 1.06–1.67, p = 0.01), independent of CVD risk factors, renal function and HDL function. The association with all-cause mortality disappeared after excluding cases of CVD specific mortality. The sensitivity, specificity, positive predictive value, and negative predictive value of anti-apoA-1 positivity for CVD mortality were 18.0%, 89.3%, 17.0%, and 90.0%, respectively. HDL functionality was not associated with anti-apoA-1 IgG levels. This prospective study demonstrates that in RTR, anti-apoA-1 IgG are independent predictors of CVD mortality and are not associated with HDL functionality.
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spelling pubmed-66791132019-08-19 Autoantibodies to Apolipoprotein A-1 as Independent Predictors of Cardiovascular Mortality in Renal Transplant Recipients Anderson, Josephine L.C. Pagano, Sabrina Virzi, Julien Dullaart, Robin P.F. Annema, Wijtske Kuipers, Folkert Bakker, Stephan J.L. Vuilleumier, Nicolas Tietge, Uwe J.F. J Clin Med Article Renal transplant recipients (RTRs) are known to have a high cardio-vascular disease (CVD) burden only partly explained by traditional CVD risk factors. The aim of this paper was therefore to determine: i) the prognostic value of autoantibodies against apoA-1 (anti-apoA-1 IgG) for incidence of CVD mortality, all-cause mortality and graft failure in RTR. Four hundred and sixty two (462) prospectively included RTRs were followed for 7.0 years. Baseline anti-apoA-1 IgG were determined and associations with incidence of CVD mortality (n = 48), all-cause mortality (n = 92) and graft failure (n = 39) were tested. Kaplan–Meier analyses demonstrated significant associations between tertiles of anti-apoA-1 IgG and CVD mortality (log rank test: p = 0.048). Adjusted Cox regression analysis showed a 54% increase in risk for CVD mortality for each anti-apoA-1 IgG levels standard deviation increase (hazard ratio [HR]: 1.54, 95% Confidence Interval [95%CI]: 1.14–2.05, p = 0.005), and a 33% increase for all-cause mortality (HR: 1.33; 95%CI: 1.06–1.67, p = 0.01), independent of CVD risk factors, renal function and HDL function. The association with all-cause mortality disappeared after excluding cases of CVD specific mortality. The sensitivity, specificity, positive predictive value, and negative predictive value of anti-apoA-1 positivity for CVD mortality were 18.0%, 89.3%, 17.0%, and 90.0%, respectively. HDL functionality was not associated with anti-apoA-1 IgG levels. This prospective study demonstrates that in RTR, anti-apoA-1 IgG are independent predictors of CVD mortality and are not associated with HDL functionality. MDPI 2019-06-29 /pmc/articles/PMC6679113/ /pubmed/31261925 http://dx.doi.org/10.3390/jcm8070948 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Anderson, Josephine L.C.
Pagano, Sabrina
Virzi, Julien
Dullaart, Robin P.F.
Annema, Wijtske
Kuipers, Folkert
Bakker, Stephan J.L.
Vuilleumier, Nicolas
Tietge, Uwe J.F.
Autoantibodies to Apolipoprotein A-1 as Independent Predictors of Cardiovascular Mortality in Renal Transplant Recipients
title Autoantibodies to Apolipoprotein A-1 as Independent Predictors of Cardiovascular Mortality in Renal Transplant Recipients
title_full Autoantibodies to Apolipoprotein A-1 as Independent Predictors of Cardiovascular Mortality in Renal Transplant Recipients
title_fullStr Autoantibodies to Apolipoprotein A-1 as Independent Predictors of Cardiovascular Mortality in Renal Transplant Recipients
title_full_unstemmed Autoantibodies to Apolipoprotein A-1 as Independent Predictors of Cardiovascular Mortality in Renal Transplant Recipients
title_short Autoantibodies to Apolipoprotein A-1 as Independent Predictors of Cardiovascular Mortality in Renal Transplant Recipients
title_sort autoantibodies to apolipoprotein a-1 as independent predictors of cardiovascular mortality in renal transplant recipients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679113/
https://www.ncbi.nlm.nih.gov/pubmed/31261925
http://dx.doi.org/10.3390/jcm8070948
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