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The Role of Leukotrienes as Potential Therapeutic Targets in Allergic Disorders
Leukotrienes (LTs) are lipid mediators that play pivotal roles in acute and chronic inflammation and allergic diseases. They exert their biological effects by binding to specific G-protein-coupled receptors. Each LT receptor subtype exhibits unique functions and expression patterns. LTs play roles i...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679143/ https://www.ncbi.nlm.nih.gov/pubmed/31336653 http://dx.doi.org/10.3390/ijms20143580 |
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author | Jo-Watanabe, Airi Okuno, Toshiaki Yokomizo, Takehiko |
author_facet | Jo-Watanabe, Airi Okuno, Toshiaki Yokomizo, Takehiko |
author_sort | Jo-Watanabe, Airi |
collection | PubMed |
description | Leukotrienes (LTs) are lipid mediators that play pivotal roles in acute and chronic inflammation and allergic diseases. They exert their biological effects by binding to specific G-protein-coupled receptors. Each LT receptor subtype exhibits unique functions and expression patterns. LTs play roles in various allergic diseases, including asthma (neutrophilic asthma and aspirin-sensitive asthma), allergic rhinitis, atopic dermatitis, allergic conjunctivitis, and anaphylaxis. This review summarizes the biology of LTs and their receptors, recent developments in the area of anti-LT strategies (in settings such as ongoing clinical studies), and prospects for future therapeutic applications. |
format | Online Article Text |
id | pubmed-6679143 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-66791432019-08-19 The Role of Leukotrienes as Potential Therapeutic Targets in Allergic Disorders Jo-Watanabe, Airi Okuno, Toshiaki Yokomizo, Takehiko Int J Mol Sci Review Leukotrienes (LTs) are lipid mediators that play pivotal roles in acute and chronic inflammation and allergic diseases. They exert their biological effects by binding to specific G-protein-coupled receptors. Each LT receptor subtype exhibits unique functions and expression patterns. LTs play roles in various allergic diseases, including asthma (neutrophilic asthma and aspirin-sensitive asthma), allergic rhinitis, atopic dermatitis, allergic conjunctivitis, and anaphylaxis. This review summarizes the biology of LTs and their receptors, recent developments in the area of anti-LT strategies (in settings such as ongoing clinical studies), and prospects for future therapeutic applications. MDPI 2019-07-22 /pmc/articles/PMC6679143/ /pubmed/31336653 http://dx.doi.org/10.3390/ijms20143580 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Jo-Watanabe, Airi Okuno, Toshiaki Yokomizo, Takehiko The Role of Leukotrienes as Potential Therapeutic Targets in Allergic Disorders |
title | The Role of Leukotrienes as Potential Therapeutic Targets in Allergic Disorders |
title_full | The Role of Leukotrienes as Potential Therapeutic Targets in Allergic Disorders |
title_fullStr | The Role of Leukotrienes as Potential Therapeutic Targets in Allergic Disorders |
title_full_unstemmed | The Role of Leukotrienes as Potential Therapeutic Targets in Allergic Disorders |
title_short | The Role of Leukotrienes as Potential Therapeutic Targets in Allergic Disorders |
title_sort | role of leukotrienes as potential therapeutic targets in allergic disorders |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679143/ https://www.ncbi.nlm.nih.gov/pubmed/31336653 http://dx.doi.org/10.3390/ijms20143580 |
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