Cargando…

Defining Bronchial Asthma with Phosphoinositide 3-Kinase Delta Activation: Towards Endotype-Driven Management

Phosphoinositide 3-kinase (PI3K) pathways play a critical role in orchestrating the chronic inflammation and the structural changes of the airways in patients with asthma. Recently, a great deal of progress has been made in developing selective and effective PI3K-targeted therapies on the basis of a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jeong, Jae Seok, Kim, Jong Seung, Kim, So Ri, Lee, Yong Chul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679152/ https://www.ncbi.nlm.nih.gov/pubmed/31323822 http://dx.doi.org/10.3390/ijms20143525

Ejemplares similares

Phosphoinositide 3-kinase-delta could be a biomarker for eosinophilic nasal polyps
por: Kim, Jong Seung, et al.
Publicado: (2018)

Defining Pediatric Asthma: Phenotypes to Endotypes and Beyond
por: Conrad, Laura A., et al.
Publicado: (2020)

Bronchial thermoplasty in asthma: an exploratory histopathological evaluation in distinct asthma endotypes/phenotypes
por: Papakonstantinou, Eleni, et al.
Publicado: (2021)

Data-Driven Asthma Endotypes Defined from Blood Biomarker and Gene Expression Data
por: George, Barbara Jane, et al.
Publicado: (2015)

The Advance of Personalized and Stratified Therapies in Bronchial Asthma: Phenotypes – Endotypes – Biomarkers
por: Lauer, Sebastian, et al.
Publicado: (2014)

The Roles of Phytochemicals in Bronchial Asthma
por: Park, Hee Sun, et al.
Publicado: (2010)

A Novel Insight on Endotyping Heterogeneous Severe Asthma Based on Endoplasmic Reticulum Stress: Beyond the “Type 2/Non-Type 2 Dichotomy”
por: Jeong, Jae Seok, et al.
Publicado: (2019)

Defining an embryonal rhabdomyosarcoma endotype
por: Ricker, Cora A., et al.
Publicado: (2020)

Asthma Endotyping and Biomarkers in Childhood Asthma
por: Licari, Amelia, et al.
Publicado: (2018)

Asthma Endotypes and an Overview of Targeted Therapy for Asthma
por: Svenningsen, Sarah, et al.
Publicado: (2017)

Respiratory Manifestations of the Activated Phosphoinositide 3-Kinase Delta Syndrome
por: Condliffe, Alison M., et al.
Publicado: (2018)

Phenotypes and endotypes of severe asthma in children
por: Yoo, Young
Publicado: (2013)

Endotyping Asthma: Profiling the Metabolic Dimension?
por: Wilde, Michael J., et al.
Publicado: (2021)

Sepsis Endotypes Defined By Cytokine Trajectory Analysis
por: Zhu, L, et al.
Publicado: (2015)

Defining adult asthma endotypes by clinical features and patterns of volatile organic compounds in exhaled air
por: Meyer, Norbert, et al.
Publicado: (2014)

Airway epithelial phosphoinositide 3-kinase-δ contributes to the modulation of fungi-induced innate immune response
por: Jeong, Jae Seok, et al.
Publicado: (2018)

Arginine metabolic endotypes related to asthma severity
por: Xu, Weiling, et al.
Publicado: (2017)

Novel Biological Therapies for Severe Asthma Endotypes
por: Pelaia, Corrado, et al.
Publicado: (2022)

Discerning asthma endotypes through comorbidity mapping
por: Jia, Gengjie, et al.
Publicado: (2022)

Next steps in precision approaches for asthma-proteomics and asthma endotypes
por: Brasier, Allan R.
Publicado: (2022)

Drug Signature-based Finding of Additional Clinical Use of LC28-0126 for Neutrophilic Bronchial Asthma
por: Shin, Eunji, et al.
Publicado: (2015)

Phosphoinositide 3-kinase-δ regulates fungus-induced allergic lung inflammation through endoplasmic reticulum stress
por: Lee, Kyung Sun, et al.
Publicado: (2016)

Natural Course of Activated Phosphoinositide 3-Kinase Delta Syndrome in Childhood and Adolescence
por: Bloomfield, Marketa, et al.
Publicado: (2021)

Cellular Notch responsiveness is defined by phosphoinositide 3-kinase-dependent signals
por: Mckenzie, Grahame, et al.
Publicado: (2006)

Eosinophils as Drivers of Severe Eosinophilic Asthma: Endotypes or Plasticity?
por: Van Hulst, Glenn, et al.
Publicado: (2021)

From spirometry to spatial omics in pursuit of asthma endotypes
por: Hinks, Timothy S. C.
Publicado: (2022)

Eosinophilic Asthma, Phenotypes-Endotypes and Current Biomarkers of Choice
por: Porpodis, Konstantinos, et al.
Publicado: (2022)

Childhood asthma phenotypes and endotypes: a glance into the mosaic
por: Foppiano, Francesco, et al.
Publicado: (2023)

Phosphoinositide 3′-kinase delta: turning off BCR signaling in Chronic Lymphocytic Leukemia
por: Hoellenriegel, Julia, et al.
Publicado: (2011)

Exhaustion of the CD8(+) T Cell Compartment in Patients with Mutations in Phosphoinositide 3-Kinase Delta
por: Wentink, Marjolein W. J., et al.
Publicado: (2018)

Endotype-driven treatment in chronic upper airway diseases
por: De Greve, Glynnis, et al.
Publicado: (2017)

Activation of the essential kinase PDK1 by phosphoinositide-driven trans-autophosphorylation
por: Levina, Aleksandra, et al.
Publicado: (2022)

Endotypes of difficult-to-control asthma in inner-city African American children
por: Brown, K. R., et al.
Publicado: (2017)

Exhaled breath condensate metabolome clusters for endotype discovery in asthma
por: Sinha, Anirban, et al.
Publicado: (2017)

An altered sputum macrophage transcriptome contributes to the neutrophilic asthma endotype
por: Fricker, Michael, et al.
Publicado: (2021)

Phosphoinositide 3-Kinase Inhibitor-Induced Hyperglycemia
por: Shey, Susan, et al.
Publicado: (2021)

Does the Difference in Microbial Patterns in the Airways Induce Distinct Endotypes of Asthma?
por: Cho, Young Joo
Publicado: (2020)

Allergic fungal airways disease (AFAD): an under-recognised asthma endotype
por: Pashley, Catherine H., et al.
Publicado: (2021)

The Intersection between Autoimmunity, Macrophage Dysfunction, Endotype, and Exacerbations in Severe Asthma
por: Murphy, Ryan C., et al.
Publicado: (2022)

Molecular T2 asthma phenotypes are stable but heterogeneous: the usefulness of periostin for endotyping
por: Bobolea, Irina, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_1n12trc8vt642mv4hft2sjb1v6