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Liquid Biopsy in Glioblastoma: Opportunities, Applications and Challenges

Liquid biopsy represents a minimally invasive procedure that can provide similar information from body fluids to what is usually obtained from a tissue biopsy sample. Its implementation in the clinical setting might significantly renew the field of medical oncology, facilitating the introduction of...

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Autores principales: Saenz-Antoñanzas, Ander, Auzmendi-Iriarte, Jaione, Carrasco-Garcia, Estefania, Moreno-Cugnon, Leire, Ruiz, Irune, Villanua, Jorge, Egaña, Larraitz, Otaegui, David, Samprón, Nicolás, Matheu, Ander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679205/
https://www.ncbi.nlm.nih.gov/pubmed/31284524
http://dx.doi.org/10.3390/cancers11070950
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author Saenz-Antoñanzas, Ander
Auzmendi-Iriarte, Jaione
Carrasco-Garcia, Estefania
Moreno-Cugnon, Leire
Ruiz, Irune
Villanua, Jorge
Egaña, Larraitz
Otaegui, David
Samprón, Nicolás
Matheu, Ander
author_facet Saenz-Antoñanzas, Ander
Auzmendi-Iriarte, Jaione
Carrasco-Garcia, Estefania
Moreno-Cugnon, Leire
Ruiz, Irune
Villanua, Jorge
Egaña, Larraitz
Otaegui, David
Samprón, Nicolás
Matheu, Ander
author_sort Saenz-Antoñanzas, Ander
collection PubMed
description Liquid biopsy represents a minimally invasive procedure that can provide similar information from body fluids to what is usually obtained from a tissue biopsy sample. Its implementation in the clinical setting might significantly renew the field of medical oncology, facilitating the introduction of the concepts of precision medicine and patient-tailored therapies. These advances may be useful in the diagnosis of brain tumors that currently require surgery for tissue collection, or to perform genetic tumor profiling for disease classification and guidance of therapy. In this review, we will summarize the most recent advances and putative applications of liquid biopsy in glioblastoma, the most common and malignant adult brain tumor. Moreover, we will discuss the remaining challenges and hurdles in terms of technology and biology for its clinical application.
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spelling pubmed-66792052019-08-19 Liquid Biopsy in Glioblastoma: Opportunities, Applications and Challenges Saenz-Antoñanzas, Ander Auzmendi-Iriarte, Jaione Carrasco-Garcia, Estefania Moreno-Cugnon, Leire Ruiz, Irune Villanua, Jorge Egaña, Larraitz Otaegui, David Samprón, Nicolás Matheu, Ander Cancers (Basel) Review Liquid biopsy represents a minimally invasive procedure that can provide similar information from body fluids to what is usually obtained from a tissue biopsy sample. Its implementation in the clinical setting might significantly renew the field of medical oncology, facilitating the introduction of the concepts of precision medicine and patient-tailored therapies. These advances may be useful in the diagnosis of brain tumors that currently require surgery for tissue collection, or to perform genetic tumor profiling for disease classification and guidance of therapy. In this review, we will summarize the most recent advances and putative applications of liquid biopsy in glioblastoma, the most common and malignant adult brain tumor. Moreover, we will discuss the remaining challenges and hurdles in terms of technology and biology for its clinical application. MDPI 2019-07-05 /pmc/articles/PMC6679205/ /pubmed/31284524 http://dx.doi.org/10.3390/cancers11070950 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Saenz-Antoñanzas, Ander
Auzmendi-Iriarte, Jaione
Carrasco-Garcia, Estefania
Moreno-Cugnon, Leire
Ruiz, Irune
Villanua, Jorge
Egaña, Larraitz
Otaegui, David
Samprón, Nicolás
Matheu, Ander
Liquid Biopsy in Glioblastoma: Opportunities, Applications and Challenges
title Liquid Biopsy in Glioblastoma: Opportunities, Applications and Challenges
title_full Liquid Biopsy in Glioblastoma: Opportunities, Applications and Challenges
title_fullStr Liquid Biopsy in Glioblastoma: Opportunities, Applications and Challenges
title_full_unstemmed Liquid Biopsy in Glioblastoma: Opportunities, Applications and Challenges
title_short Liquid Biopsy in Glioblastoma: Opportunities, Applications and Challenges
title_sort liquid biopsy in glioblastoma: opportunities, applications and challenges
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679205/
https://www.ncbi.nlm.nih.gov/pubmed/31284524
http://dx.doi.org/10.3390/cancers11070950
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