Free-Energy Calculations for Bioisosteric Modifications of A(3) Adenosine Receptor Antagonists

Adenosine receptors are a family of G protein-coupled receptors with increased attention as drug targets on different indications. We investigate the thermodynamics of ligand binding to the A(3) adenosine receptor subtype, focusing on a recently reported series of diarylacetamidopyridine inhibitors...

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Detalles Bibliográficos
Autores principales: Jandova, Zuzana, Jespers, Willem, Sotelo, Eddy, Gutiérrez-de-Terán, Hugo, Oostenbrink, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679372/
https://www.ncbi.nlm.nih.gov/pubmed/31315296
http://dx.doi.org/10.3390/ijms20143499

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679372/
https://www.ncbi.nlm.nih.gov/pubmed/31315296
http://dx.doi.org/10.3390/ijms20143499

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