The effects of crizotinib in a transgenic Drosophila model expressing the human TPM4-ALK fusion gene or TPM4

Anaplastic lymphoma kinase (ALK) fusion events lead to constitutive activation of the ALK kinase domain, thereby functioning as oncogenic drivers. These fusion proteins have been identified in numerous cancers. Crizotinib, a small molecule inhibitor of c-Met and ALK, is a Food and Drug Administratio...

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Detalles Bibliográficos
Autores principales: Kim, Yoo Jin, Cho, A-Ri, Sul, Hee Jung, Kim, Bohyun, Kim, A-Young, Kim, Hyeong Su, Seo, Jong Bok, Koh, Youngho, Zang, Dae Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679403/
https://www.ncbi.nlm.nih.gov/pubmed/31278140
http://dx.doi.org/10.1242/bio.044362

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679403/
https://www.ncbi.nlm.nih.gov/pubmed/31278140
http://dx.doi.org/10.1242/bio.044362

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