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Expression of Cytosolic Phospholipase A2 (cPLA2)-Arachidonic Acid (AA)-Cyclooxygenase-2 (COX-2) Pathway Factors in Lung Cancer Patients and Its Implication in Lung Cancer Early Detection and Prognosis

BACKGROUND: The aim of this study was to elucidate the involvement of cPLA2-AA-COX-2 pathway factors and their potential role in lung cancer early diagnosis and prognosis. MATERIAL/METHODS: We selected 80 lung cancer patients as the cancer group, and 30 normal patients were selected as the normal gr...

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Autores principales: Xin, Chunxia, Chu, Liyan, Zhang, Liangming, Geng, Dongmei, Wang, Yanchun, Sun, Dengjun, Sui, Ping, Zhao, Xuan, Gong, Zhaohua, Sui, Minghua, Zhang, Weiwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679621/
https://www.ncbi.nlm.nih.gov/pubmed/31347609
http://dx.doi.org/10.12659/MSM.915314
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author Xin, Chunxia
Chu, Liyan
Zhang, Liangming
Geng, Dongmei
Wang, Yanchun
Sun, Dengjun
Sui, Ping
Zhao, Xuan
Gong, Zhaohua
Sui, Minghua
Zhang, Weiwei
author_facet Xin, Chunxia
Chu, Liyan
Zhang, Liangming
Geng, Dongmei
Wang, Yanchun
Sun, Dengjun
Sui, Ping
Zhao, Xuan
Gong, Zhaohua
Sui, Minghua
Zhang, Weiwei
author_sort Xin, Chunxia
collection PubMed
description BACKGROUND: The aim of this study was to elucidate the involvement of cPLA2-AA-COX-2 pathway factors and their potential role in lung cancer early diagnosis and prognosis. MATERIAL/METHODS: We selected 80 lung cancer patients as the cancer group, and 30 normal patients were selected as the normal group. Serum contents of COX-2, cPLA2, COX-1, mPGES, PGE2, and PGI2 were measured, and mRNA levels of COX-2, cPLA2, COX-1, and mPGES in serum were determined. Spearman’s P-test was used to analyze the correlation between expression of PGI2 and mPGES in serum and the clinical characteristics of these lung cancer patients. The factors affecting the prognosis lung cancer were analyzed by COX regression model. RESULTS: The serum contents of COX-2, cPLA2, COX-1, mPGES, PGE2, and PGI2 in the cancer patient group were significantly higher (p<0.05) than in the normal group; after treatment, the serum contents of these factors were significantly decreased (p<0.05). However, distant metastasis had a significant effect on serum contents of mPGES and PGI2 (p<0.05), but not on the other factors. The mRNA levels of COX-2, cPLA2, COX-1, and mPGES in cancer patients were significantly higher than in normal patients. In addition, the 5-year survival rate of patients with high expression of mPGES and/or PGI2 was lower than that of the low expression group. Cox regression analysis showed that the expression of mPGES and PGI2 had statistical significance in predicting the prognosis of lung cancer. CONCLUSIONS: The cPLA2-AA-COX-2 pathway is closely associated with lung cancer. These findings are important for clinical diagnosis of lung cancer.
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spelling pubmed-66796212019-08-14 Expression of Cytosolic Phospholipase A2 (cPLA2)-Arachidonic Acid (AA)-Cyclooxygenase-2 (COX-2) Pathway Factors in Lung Cancer Patients and Its Implication in Lung Cancer Early Detection and Prognosis Xin, Chunxia Chu, Liyan Zhang, Liangming Geng, Dongmei Wang, Yanchun Sun, Dengjun Sui, Ping Zhao, Xuan Gong, Zhaohua Sui, Minghua Zhang, Weiwei Med Sci Monit Clinical Research BACKGROUND: The aim of this study was to elucidate the involvement of cPLA2-AA-COX-2 pathway factors and their potential role in lung cancer early diagnosis and prognosis. MATERIAL/METHODS: We selected 80 lung cancer patients as the cancer group, and 30 normal patients were selected as the normal group. Serum contents of COX-2, cPLA2, COX-1, mPGES, PGE2, and PGI2 were measured, and mRNA levels of COX-2, cPLA2, COX-1, and mPGES in serum were determined. Spearman’s P-test was used to analyze the correlation between expression of PGI2 and mPGES in serum and the clinical characteristics of these lung cancer patients. The factors affecting the prognosis lung cancer were analyzed by COX regression model. RESULTS: The serum contents of COX-2, cPLA2, COX-1, mPGES, PGE2, and PGI2 in the cancer patient group were significantly higher (p<0.05) than in the normal group; after treatment, the serum contents of these factors were significantly decreased (p<0.05). However, distant metastasis had a significant effect on serum contents of mPGES and PGI2 (p<0.05), but not on the other factors. The mRNA levels of COX-2, cPLA2, COX-1, and mPGES in cancer patients were significantly higher than in normal patients. In addition, the 5-year survival rate of patients with high expression of mPGES and/or PGI2 was lower than that of the low expression group. Cox regression analysis showed that the expression of mPGES and PGI2 had statistical significance in predicting the prognosis of lung cancer. CONCLUSIONS: The cPLA2-AA-COX-2 pathway is closely associated with lung cancer. These findings are important for clinical diagnosis of lung cancer. International Scientific Literature, Inc. 2019-07-26 /pmc/articles/PMC6679621/ /pubmed/31347609 http://dx.doi.org/10.12659/MSM.915314 Text en © Med Sci Monit, 2019 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Clinical Research
Xin, Chunxia
Chu, Liyan
Zhang, Liangming
Geng, Dongmei
Wang, Yanchun
Sun, Dengjun
Sui, Ping
Zhao, Xuan
Gong, Zhaohua
Sui, Minghua
Zhang, Weiwei
Expression of Cytosolic Phospholipase A2 (cPLA2)-Arachidonic Acid (AA)-Cyclooxygenase-2 (COX-2) Pathway Factors in Lung Cancer Patients and Its Implication in Lung Cancer Early Detection and Prognosis
title Expression of Cytosolic Phospholipase A2 (cPLA2)-Arachidonic Acid (AA)-Cyclooxygenase-2 (COX-2) Pathway Factors in Lung Cancer Patients and Its Implication in Lung Cancer Early Detection and Prognosis
title_full Expression of Cytosolic Phospholipase A2 (cPLA2)-Arachidonic Acid (AA)-Cyclooxygenase-2 (COX-2) Pathway Factors in Lung Cancer Patients and Its Implication in Lung Cancer Early Detection and Prognosis
title_fullStr Expression of Cytosolic Phospholipase A2 (cPLA2)-Arachidonic Acid (AA)-Cyclooxygenase-2 (COX-2) Pathway Factors in Lung Cancer Patients and Its Implication in Lung Cancer Early Detection and Prognosis
title_full_unstemmed Expression of Cytosolic Phospholipase A2 (cPLA2)-Arachidonic Acid (AA)-Cyclooxygenase-2 (COX-2) Pathway Factors in Lung Cancer Patients and Its Implication in Lung Cancer Early Detection and Prognosis
title_short Expression of Cytosolic Phospholipase A2 (cPLA2)-Arachidonic Acid (AA)-Cyclooxygenase-2 (COX-2) Pathway Factors in Lung Cancer Patients and Its Implication in Lung Cancer Early Detection and Prognosis
title_sort expression of cytosolic phospholipase a2 (cpla2)-arachidonic acid (aa)-cyclooxygenase-2 (cox-2) pathway factors in lung cancer patients and its implication in lung cancer early detection and prognosis
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679621/
https://www.ncbi.nlm.nih.gov/pubmed/31347609
http://dx.doi.org/10.12659/MSM.915314
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