Cytoplasmic SIRT1 inhibits cell migration and invasion by impeding epithelial–mesenchymal transition in ovarian carcinoma

Sirtuin1 (SIRT1) is a mammalian NAD(+)-dependent type III deacetylase that plays paramount roles in diverse cellular processes. The nucleocytoplasmic shuttling of SIRT1 was discovered more than a decade ago, but the roles of subcellular SIRT1 localization in tumor progression remain unclear. Here, w...

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Detalles Bibliográficos
Autores principales: Yang, Tong, Zhou, Ru, Yu, Shentong, Yu, Shuhong, Cui, Zhuqing, Hu, Peizhen, Liu, Jinsong, Qiao, Qing, Zhang, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679836/
https://www.ncbi.nlm.nih.gov/pubmed/31317367
http://dx.doi.org/10.1007/s11010-019-03559-y

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