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Multifidus Muscles Lipid Content Is Associated with Intervertebral Disc Degeneration: A Quantitative Magnetic Resonance Imaging Study
STUDY DESIGN: Cross-sectional study. PURPOSE: To determine the association between fatty degeneration of the multifidus muscle (Mm) and intervertebral disc degeneration (IVDD) using quantitative magnetic resonance imaging (MRI). OVERVIEW OF LITERATURE: Few studies have reported on quantitative MRI a...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society of Spine Surgery
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680039/ https://www.ncbi.nlm.nih.gov/pubmed/30866613 http://dx.doi.org/10.31616/asj.2018.0258 |
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author | Ogon, Izaya Takebayashi, Tsuneo Takashima, Hiroyuki Morita, Tomonori Oshigiri, Tsutomu Terashima, Yoshinori Yoshimoto, Mitsunori Yamashita, Toshihiko |
author_facet | Ogon, Izaya Takebayashi, Tsuneo Takashima, Hiroyuki Morita, Tomonori Oshigiri, Tsutomu Terashima, Yoshinori Yoshimoto, Mitsunori Yamashita, Toshihiko |
author_sort | Ogon, Izaya |
collection | PubMed |
description | STUDY DESIGN: Cross-sectional study. PURPOSE: To determine the association between fatty degeneration of the multifidus muscle (Mm) and intervertebral disc degeneration (IVDD) using quantitative magnetic resonance imaging (MRI). OVERVIEW OF LITERATURE: Few studies have reported on quantitative MRI analysis of the relation between the Mm and IVDD. METHODS: The subjects with chronic low back pain comprised 45 patients (19 males, 26 females; mean age, 63.8±2.0 years; range, 41–79 years). We analyzed the intramyocellular lipids (IMCL) and extramyocellular lipids (EMCL) of the Mm using magnetic resonance spectroscopy. The T2 values of the anterior annulus fibrosus (AF), nucleus pulposus (NP), and posterior AF were evaluated using MRI T2 mapping. We compared the possible correlations of IMCL and EMCL of the Mm with the T2 values of anterior AF, NP, and posterior AF. RESULTS: There was a significant negative correlation between IMCL and T2 values of the anterior AF (r=−0.65, p<0.01). There were no significant correlations between the IMCL and T2 values of NP (r=−0.16, p=0.30) and posterior AF (r=0.07, p=0.62). There were no significant correlations between the EMCL and T2 values of the anterior AF (r=−0.11, p=0.46), NP (r=0.15, p=0.32), and posterior AF (r=0.07, p=0.66). After adjustment for age and sex using multiple linear regression analysis, there was a significant negative correlation between the IMCL and T2 values of anterior AF (standardized partial regression coefficient=−0.65, p<0.01). CONCLUSIONS: The results indicated that IMCL of the Mm might be accompanied with anterior AF degeneration. Therapeutic exercises using IMCL of the Mm as evaluation index might have the potential to identify novel targets for the treatment and prevention of IVDD. |
format | Online Article Text |
id | pubmed-6680039 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Korean Society of Spine Surgery |
record_format | MEDLINE/PubMed |
spelling | pubmed-66800392019-08-05 Multifidus Muscles Lipid Content Is Associated with Intervertebral Disc Degeneration: A Quantitative Magnetic Resonance Imaging Study Ogon, Izaya Takebayashi, Tsuneo Takashima, Hiroyuki Morita, Tomonori Oshigiri, Tsutomu Terashima, Yoshinori Yoshimoto, Mitsunori Yamashita, Toshihiko Asian Spine J Clinical Study STUDY DESIGN: Cross-sectional study. PURPOSE: To determine the association between fatty degeneration of the multifidus muscle (Mm) and intervertebral disc degeneration (IVDD) using quantitative magnetic resonance imaging (MRI). OVERVIEW OF LITERATURE: Few studies have reported on quantitative MRI analysis of the relation between the Mm and IVDD. METHODS: The subjects with chronic low back pain comprised 45 patients (19 males, 26 females; mean age, 63.8±2.0 years; range, 41–79 years). We analyzed the intramyocellular lipids (IMCL) and extramyocellular lipids (EMCL) of the Mm using magnetic resonance spectroscopy. The T2 values of the anterior annulus fibrosus (AF), nucleus pulposus (NP), and posterior AF were evaluated using MRI T2 mapping. We compared the possible correlations of IMCL and EMCL of the Mm with the T2 values of anterior AF, NP, and posterior AF. RESULTS: There was a significant negative correlation between IMCL and T2 values of the anterior AF (r=−0.65, p<0.01). There were no significant correlations between the IMCL and T2 values of NP (r=−0.16, p=0.30) and posterior AF (r=0.07, p=0.62). There were no significant correlations between the EMCL and T2 values of the anterior AF (r=−0.11, p=0.46), NP (r=0.15, p=0.32), and posterior AF (r=0.07, p=0.66). After adjustment for age and sex using multiple linear regression analysis, there was a significant negative correlation between the IMCL and T2 values of anterior AF (standardized partial regression coefficient=−0.65, p<0.01). CONCLUSIONS: The results indicated that IMCL of the Mm might be accompanied with anterior AF degeneration. Therapeutic exercises using IMCL of the Mm as evaluation index might have the potential to identify novel targets for the treatment and prevention of IVDD. Korean Society of Spine Surgery 2019-08 2019-03-15 /pmc/articles/PMC6680039/ /pubmed/30866613 http://dx.doi.org/10.31616/asj.2018.0258 Text en Copyright © 2019 by Korean Society of Spine Surgery This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Ogon, Izaya Takebayashi, Tsuneo Takashima, Hiroyuki Morita, Tomonori Oshigiri, Tsutomu Terashima, Yoshinori Yoshimoto, Mitsunori Yamashita, Toshihiko Multifidus Muscles Lipid Content Is Associated with Intervertebral Disc Degeneration: A Quantitative Magnetic Resonance Imaging Study |
title | Multifidus Muscles Lipid Content Is Associated with Intervertebral Disc Degeneration: A Quantitative Magnetic Resonance Imaging Study |
title_full | Multifidus Muscles Lipid Content Is Associated with Intervertebral Disc Degeneration: A Quantitative Magnetic Resonance Imaging Study |
title_fullStr | Multifidus Muscles Lipid Content Is Associated with Intervertebral Disc Degeneration: A Quantitative Magnetic Resonance Imaging Study |
title_full_unstemmed | Multifidus Muscles Lipid Content Is Associated with Intervertebral Disc Degeneration: A Quantitative Magnetic Resonance Imaging Study |
title_short | Multifidus Muscles Lipid Content Is Associated with Intervertebral Disc Degeneration: A Quantitative Magnetic Resonance Imaging Study |
title_sort | multifidus muscles lipid content is associated with intervertebral disc degeneration: a quantitative magnetic resonance imaging study |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680039/ https://www.ncbi.nlm.nih.gov/pubmed/30866613 http://dx.doi.org/10.31616/asj.2018.0258 |
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