TOPK inhibits autophagy by phosphorylating ULK1 and promotes glioma resistance to TMZ

ULK1, the upper-most protein of the ULK1 complex, is emerging as a crucial node in autophagy induction. However, the regulation of ULK1 is not fully understood. In this study, we identified TOPK (T-LAK cell-originated protein kinase), an oncokinase, as a novel upstream kinase to phosphorylate ULK1....

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Detalles Bibliográficos
Autores principales: Lu, Hui, Xiao, Juanjuan, Ke, Changshu, Ni, Xiaofang, Xiu, Ruijuan, Tian, Qin, Pan, Huaxiong, Zou, Ling, Wang, Fei, Ma, Tengfei, Ji, Xinying, Yuan, Ping, Liu, Lin, Zhang, Jianmin, Jia, Wei, Duan, Qiuhong, Zhu, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680050/
https://www.ncbi.nlm.nih.gov/pubmed/31378785
http://dx.doi.org/10.1038/s41419-019-1805-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680050/
https://www.ncbi.nlm.nih.gov/pubmed/31378785
http://dx.doi.org/10.1038/s41419-019-1805-9

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