Polygenic expression of teratozoospermia and normal fertility in B10.MOL‐TEN1 mouse strain

Subfertility and infertility are two major reproductive health problems in human and domestic animals. The contribution of the genotype to these conditions is poorly understood. To examine the genetic basis of male subfertility, we analyzed its relationship to sperm morphology in B10.MOL‐TEN1 mice,...

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Autores principales: Hirawatari, Keitaro, Hanzawa, Naoto, Kuwahara, Maki, Aoyama, Hiroaki, Miura, Ikuo, Wakana, Shigeharu, Gotoh, Hideo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680107/
https://www.ncbi.nlm.nih.gov/pubmed/25559406
http://dx.doi.org/10.1111/cga.12102
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author Hirawatari, Keitaro
Hanzawa, Naoto
Kuwahara, Maki
Aoyama, Hiroaki
Miura, Ikuo
Wakana, Shigeharu
Gotoh, Hideo
author_facet Hirawatari, Keitaro
Hanzawa, Naoto
Kuwahara, Maki
Aoyama, Hiroaki
Miura, Ikuo
Wakana, Shigeharu
Gotoh, Hideo
author_sort Hirawatari, Keitaro
collection PubMed
description Subfertility and infertility are two major reproductive health problems in human and domestic animals. The contribution of the genotype to these conditions is poorly understood. To examine the genetic basis of male subfertility, we analyzed its relationship to sperm morphology in B10.MOL‐TEN1 mice, which shows high‐frequencies (about 50%) of morphologically abnormal sperm. Drastic histological changes were also found in the testis of the B10.MOL‐TEN1. Segregation analysis showed that the abnormal sperm phenotype in B10.MOL‐TEN1 was inherited and was predictably controlled by at least three loci. We also found that male fertility of this strain was normal. These findings indicate a complicated relationship between sperm morphology and male subfertility.
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spelling pubmed-66801072019-08-09 Polygenic expression of teratozoospermia and normal fertility in B10.MOL‐TEN1 mouse strain Hirawatari, Keitaro Hanzawa, Naoto Kuwahara, Maki Aoyama, Hiroaki Miura, Ikuo Wakana, Shigeharu Gotoh, Hideo Congenit Anom (Kyoto) Original Articles Subfertility and infertility are two major reproductive health problems in human and domestic animals. The contribution of the genotype to these conditions is poorly understood. To examine the genetic basis of male subfertility, we analyzed its relationship to sperm morphology in B10.MOL‐TEN1 mice, which shows high‐frequencies (about 50%) of morphologically abnormal sperm. Drastic histological changes were also found in the testis of the B10.MOL‐TEN1. Segregation analysis showed that the abnormal sperm phenotype in B10.MOL‐TEN1 was inherited and was predictably controlled by at least three loci. We also found that male fertility of this strain was normal. These findings indicate a complicated relationship between sperm morphology and male subfertility. John Wiley and Sons Inc. 2015-04-16 2015-05 /pmc/articles/PMC6680107/ /pubmed/25559406 http://dx.doi.org/10.1111/cga.12102 Text en © 2015 The Authors. Congenital Anomalies published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Teratology Society. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Hirawatari, Keitaro
Hanzawa, Naoto
Kuwahara, Maki
Aoyama, Hiroaki
Miura, Ikuo
Wakana, Shigeharu
Gotoh, Hideo
Polygenic expression of teratozoospermia and normal fertility in B10.MOL‐TEN1 mouse strain
title Polygenic expression of teratozoospermia and normal fertility in B10.MOL‐TEN1 mouse strain
title_full Polygenic expression of teratozoospermia and normal fertility in B10.MOL‐TEN1 mouse strain
title_fullStr Polygenic expression of teratozoospermia and normal fertility in B10.MOL‐TEN1 mouse strain
title_full_unstemmed Polygenic expression of teratozoospermia and normal fertility in B10.MOL‐TEN1 mouse strain
title_short Polygenic expression of teratozoospermia and normal fertility in B10.MOL‐TEN1 mouse strain
title_sort polygenic expression of teratozoospermia and normal fertility in b10.mol‐ten1 mouse strain
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680107/
https://www.ncbi.nlm.nih.gov/pubmed/25559406
http://dx.doi.org/10.1111/cga.12102
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