Cargando…

Chemotherapy does not adversely impact outcome following post‐incisional hernia repair with biomaterial mesh

BACKGROUND: Patients receiving chemotherapy are at increased risk for developing recurrent or post‐incisional hernias (PIH). Biological materials are an alternative to synthetic mesh in contaminated fields. The impact of chemotherapy on biomaterial tissue ingrowth and integration has not been well s...

Descripción completa

Detalles Bibliográficos
Autores principales: Saied, Abdul, David, Jenny, LaBarbera, Kim, Katz, Steven C., Somasundar, Ponnandai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680137/
https://www.ncbi.nlm.nih.gov/pubmed/25580588
http://dx.doi.org/10.1002/jso.23869
_version_ 1783441440856080384
author Saied, Abdul
David, Jenny
LaBarbera, Kim
Katz, Steven C.
Somasundar, Ponnandai
author_facet Saied, Abdul
David, Jenny
LaBarbera, Kim
Katz, Steven C.
Somasundar, Ponnandai
author_sort Saied, Abdul
collection PubMed
description BACKGROUND: Patients receiving chemotherapy are at increased risk for developing recurrent or post‐incisional hernias (PIH). Biological materials are an alternative to synthetic mesh in contaminated fields. The impact of chemotherapy on biomaterial tissue ingrowth and integration has not been well studied. METHODS: From 2008 to 2011 patients who underwent PIH repair with biomaterial mesh (Biodesign®) were selected. Patients were divided into two groups: those receiving chemotherapy (CT) and those not receiving chemotherapy (NCT). RESULTS: Forty‐five patients were identified, 28 (62%) in the NCT group and 17 (38%) in the CT group. Median follow up for NCT and CT groups were 27 and 17 months, respectively. A total of 9/45 (20%) surgical site infections (SSI) were diagnosed, with 6/28 (21%) in the NCT and 3/17 (18%) in the CT group (P = 0.53). Seroma formation was seen in 5/28 (18%) of NCT patients and 4/17 (23%) in CT group (P = 0.46). Overall hernia recurrence rate was 22%, and the rates of recurrence were similar among the CT 3/17 (18%) and NCT 7/28 (25%) groups (P = 0.42). CONCLUSION: The use of perioperative chemotherapy did not increase the rate of wound complications following PIH repair with biologic mesh in this group of patients. J. Surg. Oncol. 2015 111:725–728. © 2015 The Authors. Journal of Surgical Oncology Published by Wiley Periodicals, Inc.
format Online
Article
Text
id pubmed-6680137
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-66801372019-08-09 Chemotherapy does not adversely impact outcome following post‐incisional hernia repair with biomaterial mesh Saied, Abdul David, Jenny LaBarbera, Kim Katz, Steven C. Somasundar, Ponnandai J Surg Oncol Research Articles BACKGROUND: Patients receiving chemotherapy are at increased risk for developing recurrent or post‐incisional hernias (PIH). Biological materials are an alternative to synthetic mesh in contaminated fields. The impact of chemotherapy on biomaterial tissue ingrowth and integration has not been well studied. METHODS: From 2008 to 2011 patients who underwent PIH repair with biomaterial mesh (Biodesign®) were selected. Patients were divided into two groups: those receiving chemotherapy (CT) and those not receiving chemotherapy (NCT). RESULTS: Forty‐five patients were identified, 28 (62%) in the NCT group and 17 (38%) in the CT group. Median follow up for NCT and CT groups were 27 and 17 months, respectively. A total of 9/45 (20%) surgical site infections (SSI) were diagnosed, with 6/28 (21%) in the NCT and 3/17 (18%) in the CT group (P = 0.53). Seroma formation was seen in 5/28 (18%) of NCT patients and 4/17 (23%) in CT group (P = 0.46). Overall hernia recurrence rate was 22%, and the rates of recurrence were similar among the CT 3/17 (18%) and NCT 7/28 (25%) groups (P = 0.42). CONCLUSION: The use of perioperative chemotherapy did not increase the rate of wound complications following PIH repair with biologic mesh in this group of patients. J. Surg. Oncol. 2015 111:725–728. © 2015 The Authors. Journal of Surgical Oncology Published by Wiley Periodicals, Inc. John Wiley and Sons Inc. 2015-05-01 2015-01-08 /pmc/articles/PMC6680137/ /pubmed/25580588 http://dx.doi.org/10.1002/jso.23869 Text en © 2015 The Authors. Journal of Surgical Oncology Published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Research Articles
Saied, Abdul
David, Jenny
LaBarbera, Kim
Katz, Steven C.
Somasundar, Ponnandai
Chemotherapy does not adversely impact outcome following post‐incisional hernia repair with biomaterial mesh
title Chemotherapy does not adversely impact outcome following post‐incisional hernia repair with biomaterial mesh
title_full Chemotherapy does not adversely impact outcome following post‐incisional hernia repair with biomaterial mesh
title_fullStr Chemotherapy does not adversely impact outcome following post‐incisional hernia repair with biomaterial mesh
title_full_unstemmed Chemotherapy does not adversely impact outcome following post‐incisional hernia repair with biomaterial mesh
title_short Chemotherapy does not adversely impact outcome following post‐incisional hernia repair with biomaterial mesh
title_sort chemotherapy does not adversely impact outcome following post‐incisional hernia repair with biomaterial mesh
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680137/
https://www.ncbi.nlm.nih.gov/pubmed/25580588
http://dx.doi.org/10.1002/jso.23869
work_keys_str_mv AT saiedabdul chemotherapydoesnotadverselyimpactoutcomefollowingpostincisionalherniarepairwithbiomaterialmesh
AT davidjenny chemotherapydoesnotadverselyimpactoutcomefollowingpostincisionalherniarepairwithbiomaterialmesh
AT labarberakim chemotherapydoesnotadverselyimpactoutcomefollowingpostincisionalherniarepairwithbiomaterialmesh
AT katzstevenc chemotherapydoesnotadverselyimpactoutcomefollowingpostincisionalherniarepairwithbiomaterialmesh
AT somasundarponnandai chemotherapydoesnotadverselyimpactoutcomefollowingpostincisionalherniarepairwithbiomaterialmesh