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Checkpoint kinase 1 is essential for fetal and adult hematopoiesis

Checkpoint kinase 1 (CHK1) is critical for S‐phase fidelity and preventing premature mitotic entry in the presence of DNA damage. Tumor cells have developed a strong dependence on CHK1 for survival, and hence, this kinase has developed into a promising drug target. Chk1 deficiency in mice results in...

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Detalles Bibliográficos
Autores principales:	Schuler, Fabian, Afreen, Sehar, Manzl, Claudia, Häcker, Georg, Erlacher, Miriam, Villunger, Andreas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680171/ https://www.ncbi.nlm.nih.gov/pubmed/31379128 http://dx.doi.org/10.15252/embr.201847026

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