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Dietary patterns, cardiometabolic risk factors, and the incidence of cardiovascular disease in severe obesity

OBJECTIVE: The longitudinal associations between a dietary pattern (DP) and cardiometabolic risk factors and cardiovascular disease (CVD) incidence were investigated in a cohort of adults with severe obesity. METHODS: The analysis included 2,037 individuals with severe obesity (>34 and >38 kg/...

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Autores principales: Johns, David J., Lindroos, Anna‐Karin, Jebb, Susan A., Sjöström, Lars, Carlsson, Lena M. S., Ambrosini, Gina L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680188/
https://www.ncbi.nlm.nih.gov/pubmed/25865622
http://dx.doi.org/10.1002/oby.20920
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author Johns, David J.
Lindroos, Anna‐Karin
Jebb, Susan A.
Sjöström, Lars
Carlsson, Lena M. S.
Ambrosini, Gina L.
author_facet Johns, David J.
Lindroos, Anna‐Karin
Jebb, Susan A.
Sjöström, Lars
Carlsson, Lena M. S.
Ambrosini, Gina L.
author_sort Johns, David J.
collection PubMed
description OBJECTIVE: The longitudinal associations between a dietary pattern (DP) and cardiometabolic risk factors and cardiovascular disease (CVD) incidence were investigated in a cohort of adults with severe obesity. METHODS: The analysis included 2,037 individuals with severe obesity (>34 and >38 kg/m(2) for men and women, respectively) from the Swedish Obese Subjects study repeatedly followed up for 10 years. Reduced rank regression was used to identify a DP characterized by dietary energy density, saturated fat intake, and fiber density. Mixed models examined relationships between repeated measures of DP z‐scores and cardiometabolic risk factors. Cox proportional hazards models assessed relationships between DP scores and CVD incidence. RESULTS: An energy‐dense, high‐saturated‐fat, and low‐fiber DP was derived. A one‐unit increase in the DP z‐score between follow‐ups was associated with an increase in weight [β (SE)] (1.71 ± 0.10 kg), waist circumference (1.49 ± 0.07 cm), BMI (0.60 ± 0.34 kg/m(2)), serum cholesterol (0.06 ± 0.01 mmol/l), and serum insulin (1.22 ± 0.17 mmol/l; all P < 0.0001), as well as in serum triglycerides (0.05 ± 0.02 mmol/l; P < 0.05), systolic blood pressure (1.05 ± 0.27 mmHg; P < 0.001), and diastolic blood pressure (0.55 ± 0.16 mmHg; P < 0.05). No significant association was observed between repeated measures of the DP z‐scores and CVD incidence (HR = 0.96; 95% CI = 0.83‐1.12). CONCLUSIONS: An energy‐dense, high‐saturated‐fat, and low‐fiber DP was longitudinally associated with increases in cardiometabolic risk factors in severe obesity but not with CVD incidence.
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spelling pubmed-66801882019-08-09 Dietary patterns, cardiometabolic risk factors, and the incidence of cardiovascular disease in severe obesity Johns, David J. Lindroos, Anna‐Karin Jebb, Susan A. Sjöström, Lars Carlsson, Lena M. S. Ambrosini, Gina L. Obesity (Silver Spring) Original Articles OBJECTIVE: The longitudinal associations between a dietary pattern (DP) and cardiometabolic risk factors and cardiovascular disease (CVD) incidence were investigated in a cohort of adults with severe obesity. METHODS: The analysis included 2,037 individuals with severe obesity (>34 and >38 kg/m(2) for men and women, respectively) from the Swedish Obese Subjects study repeatedly followed up for 10 years. Reduced rank regression was used to identify a DP characterized by dietary energy density, saturated fat intake, and fiber density. Mixed models examined relationships between repeated measures of DP z‐scores and cardiometabolic risk factors. Cox proportional hazards models assessed relationships between DP scores and CVD incidence. RESULTS: An energy‐dense, high‐saturated‐fat, and low‐fiber DP was derived. A one‐unit increase in the DP z‐score between follow‐ups was associated with an increase in weight [β (SE)] (1.71 ± 0.10 kg), waist circumference (1.49 ± 0.07 cm), BMI (0.60 ± 0.34 kg/m(2)), serum cholesterol (0.06 ± 0.01 mmol/l), and serum insulin (1.22 ± 0.17 mmol/l; all P < 0.0001), as well as in serum triglycerides (0.05 ± 0.02 mmol/l; P < 0.05), systolic blood pressure (1.05 ± 0.27 mmHg; P < 0.001), and diastolic blood pressure (0.55 ± 0.16 mmHg; P < 0.05). No significant association was observed between repeated measures of the DP z‐scores and CVD incidence (HR = 0.96; 95% CI = 0.83‐1.12). CONCLUSIONS: An energy‐dense, high‐saturated‐fat, and low‐fiber DP was longitudinally associated with increases in cardiometabolic risk factors in severe obesity but not with CVD incidence. John Wiley and Sons Inc. 2015-05 2015-04-10 /pmc/articles/PMC6680188/ /pubmed/25865622 http://dx.doi.org/10.1002/oby.20920 Text en © 2014 The Authors Obesity published by Wiley Periodicals, Inc. on behalf of The Obesity Society (TOS) This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Johns, David J.
Lindroos, Anna‐Karin
Jebb, Susan A.
Sjöström, Lars
Carlsson, Lena M. S.
Ambrosini, Gina L.
Dietary patterns, cardiometabolic risk factors, and the incidence of cardiovascular disease in severe obesity
title Dietary patterns, cardiometabolic risk factors, and the incidence of cardiovascular disease in severe obesity
title_full Dietary patterns, cardiometabolic risk factors, and the incidence of cardiovascular disease in severe obesity
title_fullStr Dietary patterns, cardiometabolic risk factors, and the incidence of cardiovascular disease in severe obesity
title_full_unstemmed Dietary patterns, cardiometabolic risk factors, and the incidence of cardiovascular disease in severe obesity
title_short Dietary patterns, cardiometabolic risk factors, and the incidence of cardiovascular disease in severe obesity
title_sort dietary patterns, cardiometabolic risk factors, and the incidence of cardiovascular disease in severe obesity
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680188/
https://www.ncbi.nlm.nih.gov/pubmed/25865622
http://dx.doi.org/10.1002/oby.20920
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