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Valuing health‐related quality of life: An EQ‐5D‐5L value set for England

A new version of the EQ‐5D, the EQ‐5D‐5L, is available. The aim of this study is to produce a value set to support use of EQ‐5D‐5L data in decision‐making. The study design followed an international research protocol. Randomly selected members of the English general public completed 10 time trade‐of...

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Autores principales: Devlin, Nancy J., Shah, Koonal K., Feng, Yan, Mulhern, Brendan, van Hout, Ben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680214/
https://www.ncbi.nlm.nih.gov/pubmed/28833869
http://dx.doi.org/10.1002/hec.3564
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author Devlin, Nancy J.
Shah, Koonal K.
Feng, Yan
Mulhern, Brendan
van Hout, Ben
author_facet Devlin, Nancy J.
Shah, Koonal K.
Feng, Yan
Mulhern, Brendan
van Hout, Ben
author_sort Devlin, Nancy J.
collection PubMed
description A new version of the EQ‐5D, the EQ‐5D‐5L, is available. The aim of this study is to produce a value set to support use of EQ‐5D‐5L data in decision‐making. The study design followed an international research protocol. Randomly selected members of the English general public completed 10 time trade‐off and 7 discrete choice experiment tasks in face‐to‐face interviews. A 20‐parameter hybrid model was used to combine time trade‐off and discrete choice experiment data to generate values for the 3,125 EQ‐5D‐5L health states. Valuation data are available for 996 respondents. Face validity of the data has been demonstrated, with more severe health states generally given lower values. Problems with pain/discomfort and anxiety/depression received the greatest weight. Compared to the existing EQ‐5D‐3L value set, there are considerably fewer “worse than dead” states (5.1%, compared with over one third), and the minimum value is higher. Values range from −0.285 (extreme problems on all dimensions) to 0.950 (for health states 11211 and 21111). Results have important implications for users of the EQ‐5D‐5L both in England and internationally. Quality‐adjusted life year gains from interventions seeking to improve very poor health may be smaller using this value set and may previously have been overestimated.
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spelling pubmed-66802142019-08-09 Valuing health‐related quality of life: An EQ‐5D‐5L value set for England Devlin, Nancy J. Shah, Koonal K. Feng, Yan Mulhern, Brendan van Hout, Ben Health Econ Research Articles A new version of the EQ‐5D, the EQ‐5D‐5L, is available. The aim of this study is to produce a value set to support use of EQ‐5D‐5L data in decision‐making. The study design followed an international research protocol. Randomly selected members of the English general public completed 10 time trade‐off and 7 discrete choice experiment tasks in face‐to‐face interviews. A 20‐parameter hybrid model was used to combine time trade‐off and discrete choice experiment data to generate values for the 3,125 EQ‐5D‐5L health states. Valuation data are available for 996 respondents. Face validity of the data has been demonstrated, with more severe health states generally given lower values. Problems with pain/discomfort and anxiety/depression received the greatest weight. Compared to the existing EQ‐5D‐3L value set, there are considerably fewer “worse than dead” states (5.1%, compared with over one third), and the minimum value is higher. Values range from −0.285 (extreme problems on all dimensions) to 0.950 (for health states 11211 and 21111). Results have important implications for users of the EQ‐5D‐5L both in England and internationally. Quality‐adjusted life year gains from interventions seeking to improve very poor health may be smaller using this value set and may previously have been overestimated. John Wiley and Sons Inc. 2017-08-22 2018-01 /pmc/articles/PMC6680214/ /pubmed/28833869 http://dx.doi.org/10.1002/hec.3564 Text en © 2017 The Authors. Health Economics Published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Devlin, Nancy J.
Shah, Koonal K.
Feng, Yan
Mulhern, Brendan
van Hout, Ben
Valuing health‐related quality of life: An EQ‐5D‐5L value set for England
title Valuing health‐related quality of life: An EQ‐5D‐5L value set for England
title_full Valuing health‐related quality of life: An EQ‐5D‐5L value set for England
title_fullStr Valuing health‐related quality of life: An EQ‐5D‐5L value set for England
title_full_unstemmed Valuing health‐related quality of life: An EQ‐5D‐5L value set for England
title_short Valuing health‐related quality of life: An EQ‐5D‐5L value set for England
title_sort valuing health‐related quality of life: an eq‐5d‐5l value set for england
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680214/
https://www.ncbi.nlm.nih.gov/pubmed/28833869
http://dx.doi.org/10.1002/hec.3564
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