Structural Analysis using SHALiPE to Reveal RNA G‐Quadruplex Formation in Human Precursor MicroRNA

RNA G‐quadruplex (rG4) structures are of fundamental importance to biology. A novel approach is introduced to detect and structurally map rG4s at single‐nucleotide resolution in RNAs. The approach, denoted SHALiPE, couples selective 2′‐hydroxyl acylation with lithium ion‐based primer extension, and...

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Detalles Bibliográficos
Autores principales: Kwok, Chun Kit, Sahakyan, Aleksandr B., Balasubramanian, Shankar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680278/
https://www.ncbi.nlm.nih.gov/pubmed/27355429
http://dx.doi.org/10.1002/anie.201603562

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