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Relationship between Vitamin D Level and Lipid Profile in Non-Obese Children

Vitamin D deficiency is associated with not only cardiovascular disease itself but also cardiovascular risk factors, including obesity, hypertension, diabetes, hyperglycemia, and dyslipidemia. This study aimed to investigate the relationship between vitamin D level and lipid profile in non-obese chi...

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Detalles Bibliográficos
Autores principales: Kim, Mi Ra, Jeong, Su Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680594/
https://www.ncbi.nlm.nih.gov/pubmed/31262034
http://dx.doi.org/10.3390/metabo9070125
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author Kim, Mi Ra
Jeong, Su Jin
author_facet Kim, Mi Ra
Jeong, Su Jin
author_sort Kim, Mi Ra
collection PubMed
description Vitamin D deficiency is associated with not only cardiovascular disease itself but also cardiovascular risk factors, including obesity, hypertension, diabetes, hyperglycemia, and dyslipidemia. This study aimed to investigate the relationship between vitamin D level and lipid profile in non-obese children. A total of 243 non-obese healthy volunteers, aged 9–18 years, were enrolled from March to May 2017. Their height and weight were measured, and body mass index was calculated. Subjects underwent blood tests, including measurements of vitamin D (25(OH)D) level and lipid panels, and were divided into either the vitamin D-deficient group (<20 ng/mL) or normal group. The student’s t-test and a simple linear regression analysis were used to estimate the association between vitamin D level and lipid profile. Overall, 69.5% of non-obese children (n = 169) had a 25(OH)D level of less than 20 ng/mL. The vitamin D-deficient group showed higher triglyceride (TG) level and TG/high-density lipoprotein cholesterol (HDL-C) ratio than the normal group (TG level: 90.27 vs. 74.74 mmol/L, p = 0.003; TG/HDL-C ratio: 1.753 vs. 1.358, p = 0.003). Vitamin D level seems to affect the lipid profile, even in non-obese children, and a low vitamin D level may progress to dyslipidemia or obesity in non-obese children.
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spelling pubmed-66805942019-08-09 Relationship between Vitamin D Level and Lipid Profile in Non-Obese Children Kim, Mi Ra Jeong, Su Jin Metabolites Communication Vitamin D deficiency is associated with not only cardiovascular disease itself but also cardiovascular risk factors, including obesity, hypertension, diabetes, hyperglycemia, and dyslipidemia. This study aimed to investigate the relationship between vitamin D level and lipid profile in non-obese children. A total of 243 non-obese healthy volunteers, aged 9–18 years, were enrolled from March to May 2017. Their height and weight were measured, and body mass index was calculated. Subjects underwent blood tests, including measurements of vitamin D (25(OH)D) level and lipid panels, and were divided into either the vitamin D-deficient group (<20 ng/mL) or normal group. The student’s t-test and a simple linear regression analysis were used to estimate the association between vitamin D level and lipid profile. Overall, 69.5% of non-obese children (n = 169) had a 25(OH)D level of less than 20 ng/mL. The vitamin D-deficient group showed higher triglyceride (TG) level and TG/high-density lipoprotein cholesterol (HDL-C) ratio than the normal group (TG level: 90.27 vs. 74.74 mmol/L, p = 0.003; TG/HDL-C ratio: 1.753 vs. 1.358, p = 0.003). Vitamin D level seems to affect the lipid profile, even in non-obese children, and a low vitamin D level may progress to dyslipidemia or obesity in non-obese children. MDPI 2019-06-30 /pmc/articles/PMC6680594/ /pubmed/31262034 http://dx.doi.org/10.3390/metabo9070125 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Kim, Mi Ra
Jeong, Su Jin
Relationship between Vitamin D Level and Lipid Profile in Non-Obese Children
title Relationship between Vitamin D Level and Lipid Profile in Non-Obese Children
title_full Relationship between Vitamin D Level and Lipid Profile in Non-Obese Children
title_fullStr Relationship between Vitamin D Level and Lipid Profile in Non-Obese Children
title_full_unstemmed Relationship between Vitamin D Level and Lipid Profile in Non-Obese Children
title_short Relationship between Vitamin D Level and Lipid Profile in Non-Obese Children
title_sort relationship between vitamin d level and lipid profile in non-obese children
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680594/
https://www.ncbi.nlm.nih.gov/pubmed/31262034
http://dx.doi.org/10.3390/metabo9070125
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