In Vitro–In Vivo Correlations Based on In Vitro Dissolution of Parent Drug Diltiazem and Pharmacokinetics of Its Metabolite

In this study a novel type of in vitro–in vivo correlation (IVIVC) is proposed: The correlation of the in vitro parent drug dissolution data with the in vivo pharmacokinetic data of drug’s metabolite after the oral administration of the parent drug. The pharmacokinetic data for the parent drug dilti...

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Detalles Bibliográficos
Autores principales: Mircioiu, Constantin, Anuta, Valentina, Mircioiu, Ion, Nicolescu, Adrian, Fotaki, Nikoletta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680613/
https://www.ncbi.nlm.nih.gov/pubmed/31315287
http://dx.doi.org/10.3390/pharmaceutics11070344

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680613/
https://www.ncbi.nlm.nih.gov/pubmed/31315287
http://dx.doi.org/10.3390/pharmaceutics11070344

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