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Disruption of N‐acyl‐homoserine lactone‐specific signalling and virulence in clinical pathogens by marine sponge bacteria
In recent years, the marine environment has been the subject of increasing attention from biotechnological and pharmaceutical industries. A combination of unique physicochemical properties and spatial niche‐specific substrates, in wide‐ranging and extreme habitats, underscores the potential of the m...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680641/ https://www.ncbi.nlm.nih.gov/pubmed/29105344 http://dx.doi.org/10.1111/1751-7915.12867 |
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author | Gutiérrez‐Barranquero, José A. Reen, F. Jerry Parages, María L. McCarthy, Ronan Dobson, Alan D. W. O'Gara, Fergal |
author_facet | Gutiérrez‐Barranquero, José A. Reen, F. Jerry Parages, María L. McCarthy, Ronan Dobson, Alan D. W. O'Gara, Fergal |
author_sort | Gutiérrez‐Barranquero, José A. |
collection | PubMed |
description | In recent years, the marine environment has been the subject of increasing attention from biotechnological and pharmaceutical industries. A combination of unique physicochemical properties and spatial niche‐specific substrates, in wide‐ranging and extreme habitats, underscores the potential of the marine environment to deliver on functionally novel bioactivities. One such area of ongoing research is the discovery of compounds that interfere with the cell–cell signalling process called quorum sensing (QS). Described as the next generation of antimicrobials, these compounds can target virulence and persistence of clinically relevant pathogens, independent of any growth‐limiting effects. Marine sponges are a rich source of microbial diversity, with dynamic populations in a symbiotic relationship. In this study, we have harnessed the QS inhibition (QSI) potential of marine sponge microbiota and through culture‐based discovery have uncovered small molecule signal mimics that neutralize virulence phenotypes in clinical pathogens. This study describes for the first time a marine sponge Psychrobacter sp. isolate B98C22 that blocks QS signalling, while also reporting dual QS/QSI activity in the Pseudoalteromonas sp. J10 and Paracoccus JM45. Isolation of novel QSI activities has significant potential for future therapeutic development, of particular relevance in the light of the pending perfect storm of antibiotic resistance meeting antibiotic drug discovery decline. |
format | Online Article Text |
id | pubmed-6680641 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-66806412019-08-12 Disruption of N‐acyl‐homoserine lactone‐specific signalling and virulence in clinical pathogens by marine sponge bacteria Gutiérrez‐Barranquero, José A. Reen, F. Jerry Parages, María L. McCarthy, Ronan Dobson, Alan D. W. O'Gara, Fergal Microb Biotechnol Research Articles In recent years, the marine environment has been the subject of increasing attention from biotechnological and pharmaceutical industries. A combination of unique physicochemical properties and spatial niche‐specific substrates, in wide‐ranging and extreme habitats, underscores the potential of the marine environment to deliver on functionally novel bioactivities. One such area of ongoing research is the discovery of compounds that interfere with the cell–cell signalling process called quorum sensing (QS). Described as the next generation of antimicrobials, these compounds can target virulence and persistence of clinically relevant pathogens, independent of any growth‐limiting effects. Marine sponges are a rich source of microbial diversity, with dynamic populations in a symbiotic relationship. In this study, we have harnessed the QS inhibition (QSI) potential of marine sponge microbiota and through culture‐based discovery have uncovered small molecule signal mimics that neutralize virulence phenotypes in clinical pathogens. This study describes for the first time a marine sponge Psychrobacter sp. isolate B98C22 that blocks QS signalling, while also reporting dual QS/QSI activity in the Pseudoalteromonas sp. J10 and Paracoccus JM45. Isolation of novel QSI activities has significant potential for future therapeutic development, of particular relevance in the light of the pending perfect storm of antibiotic resistance meeting antibiotic drug discovery decline. John Wiley and Sons Inc. 2017-11-03 /pmc/articles/PMC6680641/ /pubmed/29105344 http://dx.doi.org/10.1111/1751-7915.12867 Text en © 2017 The Authors. Microbial Biotechnology published by John Wiley & Sons Ltd and Society for Applied Microbiology. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Gutiérrez‐Barranquero, José A. Reen, F. Jerry Parages, María L. McCarthy, Ronan Dobson, Alan D. W. O'Gara, Fergal Disruption of N‐acyl‐homoserine lactone‐specific signalling and virulence in clinical pathogens by marine sponge bacteria |
title | Disruption of N‐acyl‐homoserine lactone‐specific signalling and virulence in clinical pathogens by marine sponge bacteria |
title_full | Disruption of N‐acyl‐homoserine lactone‐specific signalling and virulence in clinical pathogens by marine sponge bacteria |
title_fullStr | Disruption of N‐acyl‐homoserine lactone‐specific signalling and virulence in clinical pathogens by marine sponge bacteria |
title_full_unstemmed | Disruption of N‐acyl‐homoserine lactone‐specific signalling and virulence in clinical pathogens by marine sponge bacteria |
title_short | Disruption of N‐acyl‐homoserine lactone‐specific signalling and virulence in clinical pathogens by marine sponge bacteria |
title_sort | disruption of n‐acyl‐homoserine lactone‐specific signalling and virulence in clinical pathogens by marine sponge bacteria |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680641/ https://www.ncbi.nlm.nih.gov/pubmed/29105344 http://dx.doi.org/10.1111/1751-7915.12867 |
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