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Controlled Drug Delivery Systems for Oral Cancer Treatment—Current Status and Future Perspectives

Oral squamous cell carcinoma (OSCC), which encompasses the oral cavity-derived malignancies, is a devastating disease causing substantial morbidity and mortality in both men and women. It is the most common subtype of the head and neck squamous cell carcinoma (HNSCC), which is ranked the sixth most...

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Autores principales: Ketabat, Farinaz, Pundir, Meenakshi, Mohabatpour, Fatemeh, Lobanova, Liubov, Koutsopoulos, Sotirios, Hadjiiski, Lubomir, Chen, Xiongbiao, Papagerakis, Petros, Papagerakis, Silvana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680655/
https://www.ncbi.nlm.nih.gov/pubmed/31262096
http://dx.doi.org/10.3390/pharmaceutics11070302
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author Ketabat, Farinaz
Pundir, Meenakshi
Mohabatpour, Fatemeh
Lobanova, Liubov
Koutsopoulos, Sotirios
Hadjiiski, Lubomir
Chen, Xiongbiao
Papagerakis, Petros
Papagerakis, Silvana
author_facet Ketabat, Farinaz
Pundir, Meenakshi
Mohabatpour, Fatemeh
Lobanova, Liubov
Koutsopoulos, Sotirios
Hadjiiski, Lubomir
Chen, Xiongbiao
Papagerakis, Petros
Papagerakis, Silvana
author_sort Ketabat, Farinaz
collection PubMed
description Oral squamous cell carcinoma (OSCC), which encompasses the oral cavity-derived malignancies, is a devastating disease causing substantial morbidity and mortality in both men and women. It is the most common subtype of the head and neck squamous cell carcinoma (HNSCC), which is ranked the sixth most common malignancy worldwide. Despite promising advancements in the conventional therapeutic approaches currently available for patients with oral cancer, many drawbacks are still to be addressed; surgical resection leads to permanent disfigurement, altered sense of self and debilitating physiological consequences, while chemo- and radio-therapies result in significant toxicities, all affecting patient wellbeing and quality of life. Thus, the development of novel therapeutic approaches or modifications of current strategies is paramount to improve individual health outcomes and survival, while early tumour detection remains a priority and significant challenge. In recent years, drug delivery systems and chronotherapy have been developed as alternative methods aiming to enhance the benefits of the current anticancer therapies, while minimizing their undesirable toxic effects on the healthy non-cancerous cells. Targeted drug delivery systems have the potential to increase drug bioavailability and bio-distribution at the site of the primary tumour. This review confers current knowledge on the diverse drug delivery methods, potential carriers (e.g., polymeric, inorganic, and combinational nanoparticles; nanolipids; hydrogels; exosomes) and anticancer targeted approaches for oral squamous cell carcinoma treatment, with an emphasis on their clinical relevance in the era of precision medicine, circadian chronobiology and patient-centred health care.
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spelling pubmed-66806552019-08-09 Controlled Drug Delivery Systems for Oral Cancer Treatment—Current Status and Future Perspectives Ketabat, Farinaz Pundir, Meenakshi Mohabatpour, Fatemeh Lobanova, Liubov Koutsopoulos, Sotirios Hadjiiski, Lubomir Chen, Xiongbiao Papagerakis, Petros Papagerakis, Silvana Pharmaceutics Review Oral squamous cell carcinoma (OSCC), which encompasses the oral cavity-derived malignancies, is a devastating disease causing substantial morbidity and mortality in both men and women. It is the most common subtype of the head and neck squamous cell carcinoma (HNSCC), which is ranked the sixth most common malignancy worldwide. Despite promising advancements in the conventional therapeutic approaches currently available for patients with oral cancer, many drawbacks are still to be addressed; surgical resection leads to permanent disfigurement, altered sense of self and debilitating physiological consequences, while chemo- and radio-therapies result in significant toxicities, all affecting patient wellbeing and quality of life. Thus, the development of novel therapeutic approaches or modifications of current strategies is paramount to improve individual health outcomes and survival, while early tumour detection remains a priority and significant challenge. In recent years, drug delivery systems and chronotherapy have been developed as alternative methods aiming to enhance the benefits of the current anticancer therapies, while minimizing their undesirable toxic effects on the healthy non-cancerous cells. Targeted drug delivery systems have the potential to increase drug bioavailability and bio-distribution at the site of the primary tumour. This review confers current knowledge on the diverse drug delivery methods, potential carriers (e.g., polymeric, inorganic, and combinational nanoparticles; nanolipids; hydrogels; exosomes) and anticancer targeted approaches for oral squamous cell carcinoma treatment, with an emphasis on their clinical relevance in the era of precision medicine, circadian chronobiology and patient-centred health care. MDPI 2019-06-30 /pmc/articles/PMC6680655/ /pubmed/31262096 http://dx.doi.org/10.3390/pharmaceutics11070302 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ketabat, Farinaz
Pundir, Meenakshi
Mohabatpour, Fatemeh
Lobanova, Liubov
Koutsopoulos, Sotirios
Hadjiiski, Lubomir
Chen, Xiongbiao
Papagerakis, Petros
Papagerakis, Silvana
Controlled Drug Delivery Systems for Oral Cancer Treatment—Current Status and Future Perspectives
title Controlled Drug Delivery Systems for Oral Cancer Treatment—Current Status and Future Perspectives
title_full Controlled Drug Delivery Systems for Oral Cancer Treatment—Current Status and Future Perspectives
title_fullStr Controlled Drug Delivery Systems for Oral Cancer Treatment—Current Status and Future Perspectives
title_full_unstemmed Controlled Drug Delivery Systems for Oral Cancer Treatment—Current Status and Future Perspectives
title_short Controlled Drug Delivery Systems for Oral Cancer Treatment—Current Status and Future Perspectives
title_sort controlled drug delivery systems for oral cancer treatment—current status and future perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680655/
https://www.ncbi.nlm.nih.gov/pubmed/31262096
http://dx.doi.org/10.3390/pharmaceutics11070302
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