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Curcumin Combination Chemotherapy: The Implication and Efficacy in Cancer

Many chemotherapeutic drugs have been used for the treatment of cancer, for instance, doxorubicin, irinotecan, 5-fluorouracil, cisplatin, and paclitaxel. However, the effectiveness of chemotherapy is limited in cancer therapy due to drug resistance, therapeutic selectivity, and undesirable side effe...

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Autores principales: Tan, Bee Ling, Norhaizan, Mohd Esa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680685/
https://www.ncbi.nlm.nih.gov/pubmed/31295906
http://dx.doi.org/10.3390/molecules24142527
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author Tan, Bee Ling
Norhaizan, Mohd Esa
author_facet Tan, Bee Ling
Norhaizan, Mohd Esa
author_sort Tan, Bee Ling
collection PubMed
description Many chemotherapeutic drugs have been used for the treatment of cancer, for instance, doxorubicin, irinotecan, 5-fluorouracil, cisplatin, and paclitaxel. However, the effectiveness of chemotherapy is limited in cancer therapy due to drug resistance, therapeutic selectivity, and undesirable side effects. The combination of therapies with natural compounds is likely to increase the effectiveness of drug treatment as well as reduce the adverse outcomes. Curcumin, a polyphenolic isolated from Curcuma longa, belongs to the rhizome of Zingiberaceae plants. Studies from in vitro and in vivo revealed that curcumin exerts many pharmacological activities with less toxic effects. The biological mechanisms underlying the anticancer activity of co-treatment curcumin and chemotherapy are complex and worth to discuss further. Therefore, this review aimed to address the molecular mechanisms of combined curcumin and chemotherapy in the treatment of cancer. The anticancer activity of combined nanoformulation of curcumin and chemotherapy was also discussed in this study. Taken together, a better understanding of the implication and underlying mechanisms of action of combined curcumin and chemotherapy may provide a useful approach to combat cancer diseases.
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spelling pubmed-66806852019-08-09 Curcumin Combination Chemotherapy: The Implication and Efficacy in Cancer Tan, Bee Ling Norhaizan, Mohd Esa Molecules Review Many chemotherapeutic drugs have been used for the treatment of cancer, for instance, doxorubicin, irinotecan, 5-fluorouracil, cisplatin, and paclitaxel. However, the effectiveness of chemotherapy is limited in cancer therapy due to drug resistance, therapeutic selectivity, and undesirable side effects. The combination of therapies with natural compounds is likely to increase the effectiveness of drug treatment as well as reduce the adverse outcomes. Curcumin, a polyphenolic isolated from Curcuma longa, belongs to the rhizome of Zingiberaceae plants. Studies from in vitro and in vivo revealed that curcumin exerts many pharmacological activities with less toxic effects. The biological mechanisms underlying the anticancer activity of co-treatment curcumin and chemotherapy are complex and worth to discuss further. Therefore, this review aimed to address the molecular mechanisms of combined curcumin and chemotherapy in the treatment of cancer. The anticancer activity of combined nanoformulation of curcumin and chemotherapy was also discussed in this study. Taken together, a better understanding of the implication and underlying mechanisms of action of combined curcumin and chemotherapy may provide a useful approach to combat cancer diseases. MDPI 2019-07-10 /pmc/articles/PMC6680685/ /pubmed/31295906 http://dx.doi.org/10.3390/molecules24142527 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tan, Bee Ling
Norhaizan, Mohd Esa
Curcumin Combination Chemotherapy: The Implication and Efficacy in Cancer
title Curcumin Combination Chemotherapy: The Implication and Efficacy in Cancer
title_full Curcumin Combination Chemotherapy: The Implication and Efficacy in Cancer
title_fullStr Curcumin Combination Chemotherapy: The Implication and Efficacy in Cancer
title_full_unstemmed Curcumin Combination Chemotherapy: The Implication and Efficacy in Cancer
title_short Curcumin Combination Chemotherapy: The Implication and Efficacy in Cancer
title_sort curcumin combination chemotherapy: the implication and efficacy in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680685/
https://www.ncbi.nlm.nih.gov/pubmed/31295906
http://dx.doi.org/10.3390/molecules24142527
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