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Alginate Gel Reinforcement with Chitin Nanowhiskers Modulates Rheological Properties and Drug Release Profile
Hydrogels are promising materials for various applications, including drug delivery, tissue engineering, and wastewater treatment. In this work, we designed an alginate (ALG) hydrogel containing partially deacetylated chitin nanowhiskers (CNW) as a filler. Gelation in the system occurred by both the...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680783/ https://www.ncbi.nlm.nih.gov/pubmed/31331095 http://dx.doi.org/10.3390/biom9070291 |
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author | Petrova, Valentina A. Elokhovskiy, Vladimir Y. Raik, Sergei V. Poshina, Daria N. Romanov, Dmitry P. Skorik, Yury A. |
author_facet | Petrova, Valentina A. Elokhovskiy, Vladimir Y. Raik, Sergei V. Poshina, Daria N. Romanov, Dmitry P. Skorik, Yury A. |
author_sort | Petrova, Valentina A. |
collection | PubMed |
description | Hydrogels are promising materials for various applications, including drug delivery, tissue engineering, and wastewater treatment. In this work, we designed an alginate (ALG) hydrogel containing partially deacetylated chitin nanowhiskers (CNW) as a filler. Gelation in the system occurred by both the protonation of alginic acid and the formation of a polyelectrolyte complex with deacetylated CNW surface chains. Morphological changes in the gel manifested as a honeycomb structure in the freeze-dried gel, unlike the layered structure of an ALG gel. Disturbance of the structural orientation of the gels by the introduction of CNW was also expressed as a decrease in the intensity of X-ray diffraction reflexes. All studied systems were non-Newtonian liquids that violated the Cox-Merz rule. An increase in the content of CNW in the ALG-CNW hydrogel resulted in increases in the yield stress, maximum Newtonian viscosity, and relaxation time. Inclusion of CNW prolonged the release of tetracycline due to changes in diffusion. The first phases (0–5 h) of the release profiles were well described by the Higuchi model. ALG-CNW hydrogels may be of interest as soft gels for controlled topical or intestinal drug delivery. |
format | Online Article Text |
id | pubmed-6680783 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-66807832019-08-09 Alginate Gel Reinforcement with Chitin Nanowhiskers Modulates Rheological Properties and Drug Release Profile Petrova, Valentina A. Elokhovskiy, Vladimir Y. Raik, Sergei V. Poshina, Daria N. Romanov, Dmitry P. Skorik, Yury A. Biomolecules Article Hydrogels are promising materials for various applications, including drug delivery, tissue engineering, and wastewater treatment. In this work, we designed an alginate (ALG) hydrogel containing partially deacetylated chitin nanowhiskers (CNW) as a filler. Gelation in the system occurred by both the protonation of alginic acid and the formation of a polyelectrolyte complex with deacetylated CNW surface chains. Morphological changes in the gel manifested as a honeycomb structure in the freeze-dried gel, unlike the layered structure of an ALG gel. Disturbance of the structural orientation of the gels by the introduction of CNW was also expressed as a decrease in the intensity of X-ray diffraction reflexes. All studied systems were non-Newtonian liquids that violated the Cox-Merz rule. An increase in the content of CNW in the ALG-CNW hydrogel resulted in increases in the yield stress, maximum Newtonian viscosity, and relaxation time. Inclusion of CNW prolonged the release of tetracycline due to changes in diffusion. The first phases (0–5 h) of the release profiles were well described by the Higuchi model. ALG-CNW hydrogels may be of interest as soft gels for controlled topical or intestinal drug delivery. MDPI 2019-07-19 /pmc/articles/PMC6680783/ /pubmed/31331095 http://dx.doi.org/10.3390/biom9070291 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Petrova, Valentina A. Elokhovskiy, Vladimir Y. Raik, Sergei V. Poshina, Daria N. Romanov, Dmitry P. Skorik, Yury A. Alginate Gel Reinforcement with Chitin Nanowhiskers Modulates Rheological Properties and Drug Release Profile |
title | Alginate Gel Reinforcement with Chitin Nanowhiskers Modulates Rheological Properties and Drug Release Profile |
title_full | Alginate Gel Reinforcement with Chitin Nanowhiskers Modulates Rheological Properties and Drug Release Profile |
title_fullStr | Alginate Gel Reinforcement with Chitin Nanowhiskers Modulates Rheological Properties and Drug Release Profile |
title_full_unstemmed | Alginate Gel Reinforcement with Chitin Nanowhiskers Modulates Rheological Properties and Drug Release Profile |
title_short | Alginate Gel Reinforcement with Chitin Nanowhiskers Modulates Rheological Properties and Drug Release Profile |
title_sort | alginate gel reinforcement with chitin nanowhiskers modulates rheological properties and drug release profile |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680783/ https://www.ncbi.nlm.nih.gov/pubmed/31331095 http://dx.doi.org/10.3390/biom9070291 |
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