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Purification of Pharmaceutical Solvents by Pervaporation through Hybrid Silica Membranes

Solvents purification mainly used in pharmaceutical field such as acetone and methyl ethyl ketone (MEK) were performed through hybrid silica membranes and from binary and multi-components mixtures. Two hybrid silica membranes—zirconia doped bis(triethoxysilyl)methane and bis(triethoxysilyl)ethane (B...

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Autores principales: La Rocca, Thomas, Carretier, Emilie, Dhaler, Didier, Louradour, Eric, Truong, Thien, Moulin, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680901/
https://www.ncbi.nlm.nih.gov/pubmed/31266215
http://dx.doi.org/10.3390/membranes9070076
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author La Rocca, Thomas
Carretier, Emilie
Dhaler, Didier
Louradour, Eric
Truong, Thien
Moulin, Philippe
author_facet La Rocca, Thomas
Carretier, Emilie
Dhaler, Didier
Louradour, Eric
Truong, Thien
Moulin, Philippe
author_sort La Rocca, Thomas
collection PubMed
description Solvents purification mainly used in pharmaceutical field such as acetone and methyl ethyl ketone (MEK) were performed through hybrid silica membranes and from binary and multi-components mixtures. Two hybrid silica membranes—zirconia doped bis(triethoxysilyl)methane and bis(triethoxysilyl)ethane (BTESE)—were studied. Flux, permeance, and separation factor were evaluated depending on temperature, composition, and number of organic compounds in the feed. Dehydration tests of acetone were operated at 30 and 45 °C following by acetone and MEK purification at 50 °C from multi-components hydro-organic mixtures where hydrophilic compounds (water, methanol) but also hydrophobic (dichloromethane (DCM) and/or toluene) were present. Results showed that the presence of Zr nanoparticles affected flux and improved selectivity in the case of dehydration. Experiments related to acetone and MEK purification, revealed a mass transfer alteration and a decrease of performance, from 99 to 97 wt% and from 98 to 95 wt% respectively, when the number of compounds in the initial feed grown up and more precisely, in the presence of DCM and toluene thus highlighting a possible coupling effect.
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spelling pubmed-66809012019-08-09 Purification of Pharmaceutical Solvents by Pervaporation through Hybrid Silica Membranes La Rocca, Thomas Carretier, Emilie Dhaler, Didier Louradour, Eric Truong, Thien Moulin, Philippe Membranes (Basel) Article Solvents purification mainly used in pharmaceutical field such as acetone and methyl ethyl ketone (MEK) were performed through hybrid silica membranes and from binary and multi-components mixtures. Two hybrid silica membranes—zirconia doped bis(triethoxysilyl)methane and bis(triethoxysilyl)ethane (BTESE)—were studied. Flux, permeance, and separation factor were evaluated depending on temperature, composition, and number of organic compounds in the feed. Dehydration tests of acetone were operated at 30 and 45 °C following by acetone and MEK purification at 50 °C from multi-components hydro-organic mixtures where hydrophilic compounds (water, methanol) but also hydrophobic (dichloromethane (DCM) and/or toluene) were present. Results showed that the presence of Zr nanoparticles affected flux and improved selectivity in the case of dehydration. Experiments related to acetone and MEK purification, revealed a mass transfer alteration and a decrease of performance, from 99 to 97 wt% and from 98 to 95 wt% respectively, when the number of compounds in the initial feed grown up and more precisely, in the presence of DCM and toluene thus highlighting a possible coupling effect. MDPI 2019-07-01 /pmc/articles/PMC6680901/ /pubmed/31266215 http://dx.doi.org/10.3390/membranes9070076 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
La Rocca, Thomas
Carretier, Emilie
Dhaler, Didier
Louradour, Eric
Truong, Thien
Moulin, Philippe
Purification of Pharmaceutical Solvents by Pervaporation through Hybrid Silica Membranes
title Purification of Pharmaceutical Solvents by Pervaporation through Hybrid Silica Membranes
title_full Purification of Pharmaceutical Solvents by Pervaporation through Hybrid Silica Membranes
title_fullStr Purification of Pharmaceutical Solvents by Pervaporation through Hybrid Silica Membranes
title_full_unstemmed Purification of Pharmaceutical Solvents by Pervaporation through Hybrid Silica Membranes
title_short Purification of Pharmaceutical Solvents by Pervaporation through Hybrid Silica Membranes
title_sort purification of pharmaceutical solvents by pervaporation through hybrid silica membranes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680901/
https://www.ncbi.nlm.nih.gov/pubmed/31266215
http://dx.doi.org/10.3390/membranes9070076
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